© The Author 2006. Published by Oxford University Press.
BRIEF COMMUNICATION |
Inconsistent Association Between the STK15 F31I Genetic Polymorphism and Breast Cancer Risk
Affiliations of authors: The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK (OF, NJ, CP, AA); Non-communicable Disease Epidemiology Unit, London School of Hygiene & Tropical Medicine, London, UK (IdSS, VM, JW, JP); Cancer Research UK Epidemiology & Genetics Unit, Institute of Cancer Research–Sutton, Surrey, UK (JP)
Correspondence to: Olivia Fletcher, PhD, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, U.K. (e-mail: olivia.fletcher{at}icr.ac.uk).
STK15 may be a low-penetrance breast cancer susceptibility gene, and several reports suggest that women who are homozygous for the polymorphic variant F31I have an increased risk of breast cancer. To evaluate this potential breast cancer allele, we genotyped 507 patients with two primary breast cancers and 875 population-based control subjects for the STK15 F31I polymorphism. All statistical tests were two-sided. The Ile/Ile homozygous genotype was not associated with an increased risk in white women of British descent. The odds ratio for developing two primary breast cancers) in Ile/Ile homozygotes was 0.63 (95% confidence interval [CI] = 0.34 to 1.13), which corresponds to an odds ratio of 0.79 (95% CI = 0.58 to 1.06) for a first primary breast cancer. A meta-analysis of this study and other published studies showed statistically significant heterogeneity in the odds ratio estimates (P<.001). This heterogeneity could reflect either population-specific linkage disequilibrium with a functional variant or artifacts such as population stratification or publication bias.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Frank, M. Wiestler, S. Kropp, K. Hemminki, A. B. Spurdle, C. Sutter, B. Wappenschmidt, X. Chen, J. Beesley, J. L. Hopper, et al. Association of a Common AKAP9 Variant With Breast Cancer Risk: A Collaborative Analysis J Natl Cancer Inst, March 19, 2008; 100(6): 437 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Fletcher, N. Johnson, L. Gibson, B. Coupland, A. Fraser, A. Leonard, I. dos Santos Silva, A. Ashworth, R. Houlston, and J. Peto Association of Genetic Variants at 8q24 with Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 702 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Schmidt, S. Reincke, A. Broeks, L. M. Braaf, F. B.L. Hogervorst, R. A.E.M. Tollenaar, N. Johnson, O. Fletcher, J. Peto, J. Tommiska, et al. Do MDM2 SNP309 and TP53 R72P Interact in Breast Cancer Susceptibility? A Large Pooled Series from the Breast Cancer Association Consortium Cancer Res., October 1, 2007; 67(19): 9584 - 9590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Couch, O. Sinilnikova, R. A. Vierkant, V. S. Pankratz, Z. S. Fredericksen, D. Stoppa-Lyonnet, I. Coupier, D. Hughes, A. Hardouin, P. Berthet, et al. AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A Consortium of Investigators of Modifiers of BRCA1/2 Study Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1416 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, D. Li, C. Wei, S. Sen, A. M. Killary, C. I. Amos, D. B. Evans, J. L. Abbruzzese, and M. L. Frazier Aurora-A and p16 Polymorphisms Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer in Caucasians Clin. Cancer Res., May 15, 2007; 13(10): 3100 - 3104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Johnson, O. Fletcher, C. Palles, M. Rudd, E. Webb, G. Sellick, I. dos Santos Silva, V. McCormack, L. Gibson, A. Fraser, et al. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility Hum. Mol. Genet., May 1, 2007; 16(9): 1051 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gu, Y. Gong, M. Huang, C. Lu, M. R. Spitz, and X. Wu Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians Carcinogenesis, February 1, 2007; 28(2): 350 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. A. Ioannidis Common genetic variants for breast cancer: 32 largely refuted candidates and larger prospects. J Natl Cancer Inst, October 4, 2006; 98(19): 1350 - 1353. [Full Text] [PDF]
|
|