© The Author 2006. Published by Oxford University Press.
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Steroid Hormone Receptor Status of Mouse Mammary Stem Cells
Affiliations of authors: VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia (MLAL, MS, FV, NCF, JEV, GJL); University of Melbourne, Victoria, Australia (MS, GJL); Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada (JS, CJE); StemCell Technologies Inc., Vancouver, British Columbia, Canada (JS); Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Melbourne, Victoria, Australia (GJL)
Correspondence to: Jane E. Visvader, PhD, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia (e-mail: visvader{at}wehi.edu.au) or Geoffrey J. Lindeman, FRACP, PhD, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia (e-mail: lindeman{at}wehi.edu.au).
The estrogen receptor 
(ER), progesterone receptor (PR), and erbB2 (Her2 in humans) are important prognostic markers of human breast cancer, and they are variably expressed in different subtypes of breast cancer. The basal subtype, for example, is negative for ER, PR, and Her2 by immunohistochemistry. We investigated the expression of these signaling molecules in enriched populations of mouse mammary stem cells and luminal cells that were isolated according to their differential expression of CD24 and the 6
1-integrin complex. We found that the basal population, which is enriched in mouse mammary stem cells, did not express ER, PR, or ErbB2/Her2 but did express epidermal growth factor receptor (EGFR)/ErbB1, whereas the subset of cells enriched for luminal cells expressed ER (37% of cells) and PR (40% of cells) but not ErbB2/Her2 or EGFR/ErbB1. Ovariectomy confirmed the importance of estrogen signaling to luminal cell proliferation but had no effect on the size of the mouse mammary stem cell-enriched population. Thus, mouse mammary stem cells were negative for ER, PR, and ErbB2 and appeared to share common properties with poor-prognosis basal breast cancer.
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- Breast Cancer Heterogeneity: A Mixture of At Least Two Main Types?
- William F. Anderson and Rayna Matsuno
J Natl Cancer Inst 2006 98: 948-951.[Extract] [Full Text] [PDF]
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