Skip Navigation

JNCI Journal of the National Cancer Institute 2006 98(1):72-75; doi:10.1093/jnci/djj007
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Mayne, S. T.
Right arrow Articles by Fraumeni, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mayne, S. T.
Right arrow Articles by Fraumeni, J. F., Jr.
Related Collections
Right arrowCorrespondence about this Article
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press.

BRIEF COMMUNICATION

Carbonated Soft Drink Consumption and Risk of Esophageal Adenocarcinoma

Susan T. Mayne, Harvey A. Risch, Robert Dubrow, Wong-Ho Chow, Marilie D. Gammon, Thomas L. Vaughan, Lauren Borchardt, Janet B. Schoenberg, Janet L. Stanford, A. Brian West, Heidi Rotterdam, William J. Blot, Joseph F. Fraumeni, Jr.

Affiliations of authors: Yale University School of Medicine and Yale Cancer Center, Department of Epidemiology and Public Health, New Haven, CT (STM, HAR, RD, LB); National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD (W-HC, JFF); University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, NC (MDG); Fred Hutchinson Cancer Research Center, Program in Epidemiology, and University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, WA (TLV, JLS); New Jersey Department of Health and Senior Services, Center for Cancer Initiatives, Trenton, NJ (JBS); Columbia University, Department of Pathology, New York, NY (HR); New York University Medical Center, Department of Pathology, New York, NY (ABW); International Epidemiology Institute, Rockville, MD (WJB)

Correspondence to: Susan T. Mayne, PhD, Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College Street, New Haven, CT 06520-8034 (e-mail: Susan.Mayne{at}yale.edu).

Carbonated soft drinks (CSDs) have been associated with gastroesophageal reflux, an established risk factor for esophageal adenocarcinoma. As both CSD consumption and esophageal adenocarcinoma incidence have sharply increased in recent decades, we examined CSD as a risk factor for esophageal and gastric cancers in a U.S. multicenter, population-based case-control study. Associations between CSD intake and risk were estimated by adjusted odds ratios (ORs), comparing the highest versus lowest quartiles of intake. All statistical tests were two-sided. Contrary to the proposed hypothesis, CSD consumption was inversely associated with esophageal adenocarcinoma risk (highest versus lowest quartiles, OR = 0.47, 95% confidence interval = 0.29 to 0.76; Ptrend = .005), due primarily to intake of diet CSD. High CSD consumption did not increase risk of any esophageal or gastric cancer subtype in men or women or when analyses were restricted to nonproxy interviews. These findings indicate that CSD consumption (especially diet CSD) is inversely associated with risk of esophageal adenocarcinoma, and thus it is not likely to have contributed to the rising incidence rates.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Correspondence about this Article

Re: Carbonated Soft Drink Consumption and Risk of Esophageal Adenocarcinoma
Mohandas K. Mallath
J Natl Cancer Inst 2006 98: 644-645. [Extract] [Full Text] [PDF]

Re: Carbonated Soft Drink Consumption and Risk of Esophageal Adenocarcinoma
Silvano Gallus, Renato Talamini, Esteve Fernandez, Luigino Dal Maso, Silvia Franceschi, and Carlo La Vecchia
J Natl Cancer Inst 2006 98: 645-646. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Therapeutic Advances in GastroenterologyHome page
J. A. Abrams
Review: Chemoprevention of esophageal adenocarcinoma
Therapeutic Advances in Gastroenterology, July 1, 2008; 1(1): 7 - 18.
[Abstract] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
U. Lim, P. Hartge, L. M. Morton, and A. Schatzkin
Consumption of Aspartame-Containing Beverages and Incidence of Hematopoietic and Brain Malignancies
Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1528 - 1529.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
U. Lim, A. F. Subar, T. Mouw, P. Hartge, L. M. Morton, R. Stolzenberg-Solomon, D. Campbell, A. R. Hollenbeck, and A. Schatzkin
Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies.
Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1654 - 1659.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
J. Lagergren, P. Viklund, and C. Jansson
Carbonated soft drinks and risk of esophageal adenocarcinoma: a population-based case-control study.
J Natl Cancer Inst, August 16, 2006; 98(16): 1158 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. K. Mallath
Re: Carbonated soft drink consumption and risk of esophageal adenocarcinoma.
J Natl Cancer Inst, May 3, 2006; 98(9): 644 - 645.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. Gallus, R. Talamini, E. Fernandez, L. Dal Maso, S. Franceschi, and C. La Vecchia
Re: Carbonated soft drink consumption and risk of esophageal adenocarcinoma.
J Natl Cancer Inst, May 3, 2006; 98(9): 645 - 646.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.