© 2005 Oxford University Press
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Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers
Affiliations of authors: Hamon Center for Therapeutic Oncology Research (HS, TT, MN, JDM, AFG), Department of Molecular Genetics (JH), Department of Internal Medicine (JDM), Department of Pharmacology (JDM) and Department of Pathology (AFG), University of Texas Southwestern Medical Center, Dallas, TX; Cancer Prevention Research, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (LL, ZF); Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan (MS, TF); Department of Pathology (IIW) and Department of Thoracic and Cardiovascular Surgery (JAR), University of Texas, MD Anderson Cancer Center, Houston, TX; The Prince Charles Hospital, Brisbane, Australia (KMF); Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan (HL); Department of Cancer and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan (HS, ST, NS)
Correspondence to: Adi F. Gazdar, MD, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-8593 (e-mail: adi.gazdar{at}utsouthwestern.edu).
Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in the pathogenesis of lung cancers is unclear. Methods: We sequenced exons 18–21 of the EGFR TK domain from genomic DNA isolated from 617 non-small-cell lung cancers (NSCLCs) and 524 normal lung tissue samples from the same patients and 36 neuroendocrine lung tumors collected from patients in Japan, Taiwan, the United States, and Australia and from 243 other epithelial cancers. Mutation status was compared with clinicopathologic features and with the presence of mutations in KRAS, a gene in the EGFR signaling pathway that is also frequently mutated in lung cancers. All statistical tests were two sided. Results: We detected a total of 134 EGFR TK domain mutations in 130 (21%) of the 617 NSCLCs but not in any of the other carcinomas, nor in nonmalignant lung tissue from the same patients. In NSCLC patients, EGFR TK domain mutations were statistically significantly more frequent in never smokers than ever smokers (51% versus 10%), in adenocarcinomas versus cancer of other histologies (40% versus 3%), in patients of East Asian ethnicity versus other ethnicities (30% versus 8%), and in females versus males (42% versus 14%; all P < .001). EGFR TK domain mutation status was not associated with patient age at diagnosis, clinical stage, the presence of bronchioloalveolar histologic features, or overall survival. The EGFR TK domain mutations we detected were of three common types: in-frame deletions in exon 19, single missense mutations in exon 21, and in-frame duplications/insertions in exon 20. Rare missense mutations were also detected in exons 18, 20, and 21. KRAS gene mutations were present in 50 (8%) of the 617 NSCLCs but not in any tumors with an EGFR TK domain mutation. Conclusions: Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers.
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Correspondence about this Article
- Re: Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers
- Jose R. Pardinas, Li Xiao, Jia Zhang, and Kai Li
J Natl Cancer Inst 2006 98: 362-363.[Extract] [Full Text] [PDF]
Editorial about this Article
- EGFR Gene Mutations: A Call for Global x Global Views of Cancer
- William R. Sellers and Matthew Meyerson
J Natl Cancer Inst 2005 97: 326-328.[Extract] [Full Text] [PDF]
Related Memo to the Media
- Press Release: Study Examines Role of EGFR Gene Mutations in Lung Cancer Development
- Sarah L. Zielinski
J Natl Cancer Inst 2005 97: 325.[Extract] [Full Text]
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
G. Sartori, A. Cavazza, A. Sgambato, A. Marchioni, F. Barbieri, L. Longo, M. Bavieri, B. Murer, E. Meschiari, S. Tamberi, et al. EGFR and K-ras Mutations Along the Spectrum of Pulmonary Epithelial Tumors of the Lung and Elaboration of a Combined Clinicopathologic and Molecular Scoring System to Predict Clinical Responsiveness to EGFR Inhibitors Am J Clin Pathol, April 1, 2009; 131(4): 478 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 D. S. Hsu, C. R. Acharya, B. S. Balakumaran, R. F. Riedel, M. K. Kim, M. Stevenson, S. Tuchman, S. Mukherjee, W. Barry, H. K. Dressman, et al. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer PNAS, March 31, 2009; 106(13): 5312 - 5317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
C. J. Langer The "Lazarus Response" in Treatment-Naive, Poor Performance Status Patients With Non-Small-Cell Lung Cancer and Epidermal Growth Factor Receptor Mutation J. Clin. Oncol., March 20, 2009; 27(9): 1350 - 1354. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jiang Overview of Gefitinib in Non-small Cell Lung Cancer: An Asian Perspective Jpn. J. Clin. Oncol., March 1, 2009; 39(3): 137 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nakanishi, S. Matsumoto, R. Iwakawa, T. Kohno, K. Suzuki, K. Tsuta, Y. Matsuno, M. Noguchi, E. Shimizu, and J. Yokota Whole Genome Comparison of Allelic Imbalance between Noninvasive and Invasive Small-Sized Lung Adenocarcinomas Cancer Res., February 15, 2009; 69(4): 1615 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Laurent-Puig, A. Lievre, and H. Blons Mutations and Response to Epidermal Growth Factor Receptor Inhibitors Clin. Cancer Res., February 15, 2009; 15(4): 1133 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A-M. Ruppert, M. Beau-Faller, A. Neuville, E. Guerin, A-C. Voegeli, B. Mennecier, M. Legrain, A. Molard, M-Y. Jeung, M-P. Gaub, et al. EGFR-TKI and lung adenocarcinoma with CNS relapse: interest of molecular follow-up Eur. Respir. J., February 1, 2009; 33(2): 436 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cappuzzo, P. A. Janne, M. Skokan, G. Finocchiaro, E. Rossi, C. Ligorio, P. A. Zucali, L. Terracciano, L. Toschi, M. Roncalli, et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients Ann. Onc., February 1, 2009; 20(2): 298 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Pantaleo, M. Nannini, A. Maleddu, S. Fanti, C. Nanni, S. Boschi, F. Lodi, G. Nicoletti, L. Landuzzi, P. L. Lollini, et al. Experimental results and related clinical implications of PET detection of epidermal growth factor receptor (EGFr) in cancer Ann. Onc., February 1, 2009; 20(2): 213 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okabe, I. Okamoto, S. Tsukioka, J. Uchida, E. Hatashita, Y. Yamada, T. Yoshida, K. Nishio, M. Fukuoka, P. A. Janne, et al. Addition of S-1 to the Epidermal Growth Factor Receptor Inhibitor Gefitinib Overcomes Gefitinib Resistance in Non-small cell Lung Cancer Cell Lines with MET Amplification Clin. Cancer Res., February 1, 2009; 15(3): 907 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nose, K. Sugio, T. Oyama, T. Nozoe, H. Uramoto, T. Iwata, T. Onitsuka, and K. Yasumoto Association Between Estrogen Receptor-{beta} Expression and Epidermal Growth Factor Receptor Mutation in the Postoperative Prognosis of Adenocarcinoma of the Lung J. Clin. Oncol., January 20, 2009; 27(3): 411 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Hirsch, R. S. Herbst, C. Olsen, K. Chansky, J. Crowley, K. Kelly, W. A. Franklin, P. A. Bunn Jr, M. Varella-Garcia, and D. R. Gandara In Reply J. Clin. Oncol., January 20, 2009; 27(3): 465 - 467. [Full Text] [PDF]
|
|
|
|
|
|
M. Soda, S. Takada, K. Takeuchi, Y. L. Choi, M. Enomoto, T. Ueno, H. Haruta, T. Hamada, Y. Yamashita, Y. Ishikawa, et al. A mouse model for EML4-ALK-positive lung cancer PNAS, December 16, 2008; 105(50): 19893 - 19897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takano, T. Fukui, Y. Ohe, K. Tsuta, S. Yamamoto, H. Nokihara, N. Yamamoto, I. Sekine, H. Kunitoh, K. Furuta, et al. EGFR Mutations Predict Survival Benefit From Gefitinib in Patients With Advanced Lung Adenocarcinoma: A Historical Comparison of Patients Treated Before and After Gefitinib Approval in Japan J. Clin. Oncol., December 1, 2008; 26(34): 5589 - 5595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-G. Wu, Y.-L. Chang, Y.-C. Hsu, J.-Y. Wu, C.-H. Yang, C.-J. Yu, M.-F. Tsai, J.-Y. Shih, and P.-C. Yang Good Response to Gefitinib in Lung Adenocarcinoma of Complex Epidermal Growth Factor Receptor (EGFR) Mutations with the Classical Mutation Pattern Oncologist, December 1, 2008; 13(12): 1276 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Pratilas, A. J. Hanrahan, E. Halilovic, Y. Persaud, J. Soh, D. Chitale, H. Shigematsu, H. Yamamoto, A. Sawai, M. Janakiraman, et al. Genetic Predictors of MEK Dependence in Non-Small Cell Lung Cancer Cancer Res., November 15, 2008; 68(22): 9375 - 9383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yonesaka, K. Zejnullahu, N. Lindeman, A. J. Homes, D. M. Jackman, F. Zhao, A. M. Rogers, B. E. Johnson, and P. A. Janne Autocrine Production of Amphiregulin Predicts Sensitivity to Both Gefitinib and Cetuximab in EGFR Wild-type Cancers Clin. Cancer Res., November 1, 2008; 14(21): 6963 - 6973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Costa, K.-S. H. Nguyen, B. C. Cho, L. V. Sequist, D. M. Jackman, G. J. Riely, B. Y. Yeap, B. Halmos, J. H. Kim, P. A. Janne, et al. Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib Clin. Cancer Res., November 1, 2008; 14(21): 7060 - 7067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Janne Gefitinib First or Gefitinib Second: Is Timing Everything in the Treatment of EGFR Mutant Non-Small Cell Lung Cancer? Am. J. Respir. Crit. Care Med., October 15, 2008; 178(8): 783 - 785. [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Wu, C.-J. Yu, C.-H. Yang, S.-G. Wu, Y.-H. Chiu, C.-H. Gow, Y.-C. Chang, Y.-C. Hsu, P.-F. Wei, J.-Y. Shih, et al. First- or Second-line Therapy with Gefitinib Produces Equal Survival in Non-Small Cell Lung Cancer Am. J. Respir. Crit. Care Med., October 15, 2008; 178(8): 847 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fichtner, J. Rolff, R. Soong, J. Hoffmann, S. Hammer, A. Sommer, M. Becker, and J. Merk Establishment of Patient-Derived Non-Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers Clin. Cancer Res., October 15, 2008; 14(20): 6456 - 6468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S-G. Wu, C-H. Gow, C-J. Yu, Y-L. Chang, C-H. Yang, Y-C. Hsu, J-Y. Shih, Y-C. Lee, and P-C. Yang Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma Eur. Respir. J., October 1, 2008; 32(4): 924 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. VanMeter, A. S. Rodriguez, E. D. Bowman, J. Jen, C. C. Harris, J. Deng, V. S. Calvert, A. Silvestri, C. Fredolini, V. Chandhoke, et al. Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer: Differential Epidermal Growth Factor Receptor (EGPR) Phosphorylation Events Associated with Mutated EGFR Compared with Wild Type Mol. Cell. Proteomics, October 1, 2008; 7(10): 1902 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tatematsu, J. Shimizu, Y. Murakami, Y. Horio, S. Nakamura, T. Hida, T. Mitsudomi, and Y. Yatabe Epidermal Growth Factor Receptor Mutations in Small Cell Lung Cancer Clin. Cancer Res., October 1, 2008; 14(19): 6092 - 6096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
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|
|
|
C.-Q. Zhu, G. da Cunha Santos, K. Ding, A. Sakurada, J.-C. Cutz, N. Liu, T. Zhang, P. Marrano, M. Whitehead, J. A. Squire, et al. Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 J. Clin. Oncol., September 10, 2008; 26(26): 4268 - 4275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamamoto, H. Shigematsu, M. Nomura, W. W. Lockwood, M. Sato, N. Okumura, J. Soh, M. Suzuki, I. I. Wistuba, K. M. Fong, et al. PIK3CA Mutations and Copy Number Gains in Human Lung Cancers Cancer Res., September 1, 2008; 68(17): 6913 - 6921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Seo, D. D. Liu, B. N. Bekele, M.-K. Kim, K. Pisters, S. M. Lippman, I. I. Wistuba, and J. S. Koo Cyclic AMP Response Element-Binding Protein Overexpression: A Feature Associated with Negative Prognosis in Never Smokers with Non-Small Cell Lung Cancer Cancer Res., August 1, 2008; 68(15): 6065 - 6073. [Abstract] [Full Text] [PDF]
|
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 |
|
 X. Tang, M. Varella-Garcia, A. C. Xavier, E. Massarelli, N. Ozburn, C. Moran, and I. I. Wistuba Epidermal Growth Factor Receptor Abnormalities in the Pathogenesis and Progression of Lung Adenocarcinomas Cancer Prevention Research, August 1, 2008; 1(3): 192 - 200. [Abstract] [Full Text] [PDF]
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|
|
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J.-Y. Wu, S.-G. Wu, C.-H. Yang, C.-H. Gow, Y.-L. Chang, C.-J. Yu, J.-Y. Shih, and P.-C. Yang Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Mutations Is Associated with Poor Gefitinib Treatment Response Clin. Cancer Res., August 1, 2008; 14(15): 4877 - 4882. [Abstract] [Full Text] [PDF]
|
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F. Braiteh, R. Kurzrock, and F. M. Johnson Trichomegaly of the Eyelashes After Lung Cancer Treatment with the Epidermal Growth Factor Receptor Inhibitor Erlotinib J. Clin. Oncol., July 10, 2008; 26(20): 3460 - 3462. [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Choi, K. Takeuchi, M. Soda, K. Inamura, Y. Togashi, S. Hatano, M. Enomoto, T. Hamada, H. Haruta, H. Watanabe, et al. Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non-Small Cell Lung Cancer Cancer Res., July 1, 2008; 68(13): 4971 - 4976. [Abstract] [Full Text] [PDF]
|
|
|
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D. W. Bell, B. W. Brannigan, K. Matsuo, D. M. Finkelstein, R. Sordella, J. Settleman, T. Mitsudomi, and D. A. Haber Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms Clin. Cancer Res., July 1, 2008; 14(13): 4079 - 4084. [Abstract] [Full Text] [PDF]
|
|
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|
|
E. Felip, F. Rojo, M. Reck, A. Heller, B. Klughammer, G. Sala, S. Cedres, S. Peralta, H. Maacke, D. Foernzler, et al. A Phase II Pharmacodynamic Study of Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy Clin. Cancer Res., June 15, 2008; 14(12): 3867 - 3874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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J. A. Engelman and P. A. Janne Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Clin. Cancer Res., May 15, 2008; 14(10): 2895 - 2899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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P. S. Hodkinson, A. MacKinnon, and T. Sethi Targeting Growth Factors in Lung Cancer Chest, May 1, 2008; 133(5): 1209 - 1216. [Abstract] [Full Text] [PDF]
|
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|
|
|
S. T. Ruosaari, P. E.H. Nymark, M. M. Aavikko, E. Kettunen, S. Knuutila, J. Hollmen, H. Norppa, and S. L. Anttila Aberrations of chromosome 19 in asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial epithelial cells in vitro Carcinogenesis, May 1, 2008; 29(5): 913 - 917. [Abstract] [Full Text] [PDF]
|
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 |
|
 A. R. Li, D. Chitale, G. J. Riely, W. Pao, V. A. Miller, M. F. Zakowski, V. Rusch, M. G. Kris, and M. Ladanyi EGFR Mutations in Lung Adenocarcinomas: Clinical Testing Experience and Relationship to EGFR Gene Copy Number and Immunohistochemical Expression J. Mol. Diagn., May 1, 2008; 10(3): 242 - 248. [Abstract] [Full Text] [PDF]
|
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|
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|
A. Kumar, E. T. Petri, B. Halmos, and T. J. Boggon Structure and Clinical Relevance of the Epidermal Growth Factor Receptor in Human Cancer J. Clin. Oncol., April 1, 2008; 26(10): 1742 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
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Y. Yatabe, T. Takahashi, and T. Mitsudomi Epidermal Growth Factor Receptor Gene Amplification Is Acquired in Association with Tumor Progression of EGFR-Mutated Lung Cancer Cancer Res., April 1, 2008; 68(7): 2106 - 2111. [Abstract] [Full Text] [PDF]
|
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|
|
G D Smith, B E Chadwick, C Willmore-Payne, and J S Bentz Detection of epidermal growth factor receptor gene mutations in cytology specimens from patients with non-small cell lung cancer utilising high-resolution melting amplicon analysis J. Clin. Pathol., April 1, 2008; 61(4): 487 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ciardiello and G. Tortora EGFR Antagonists in Cancer Treatment N. Engl. J. Med., March 13, 2008; 358(11): 1160 - 1174. [Full Text] [PDF]
|
|
|
|
|
|
F. Pinter, J. Papay, A. Almasi, Z. Sapi, E. Szabo, M. Kanya, A. Tamasi, B. Jori, E. Varkondi, J. Moldvay, et al. Epidermal Growth Factor Receptor (EGFR) High Gene Copy Number and Activating Mutations in Lung Adenocarcinomas Are Not Consistently Accompanied by Positivity for EGFR Protein by Standard Immunohistochemistry J. Mol. Diagn., March 1, 2008; 10(2): 160 - 168. [Abstract] [Full Text] [PDF]
|
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|
|
|
R. Jagadeeswaran, H. Surawska, S. Krishnaswamy, V. Janamanchi, A. C. Mackinnon, T. Y. Seiwert, S. Loganathan, R. Kanteti, T. Reichman, V. Nallasura, et al. Paxillin Is a Target for Somatic Mutations in Lung Cancer: Implications for Cell Growth and Invasion Cancer Res., January 1, 2008; 68(1): 132 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Gow, C.-R. Chien, Y.-L. Chang, Y.-H. Chiu, S.-H. Kuo, J.-Y. Shih, Y.-C. Chang, C.-J. Yu, C.-H. Yang, and P.-C. Yang Radiotherapy in Lung Adenocarcinoma with Brain Metastases: Effects of Activating Epidermal Growth Factor Receptor Mutations on Clinical Response Clin. Cancer Res., January 1, 2008; 14(1): 162 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Toyooka, K. Matsuo, H. Shigematsu, T. Kosaka, M. Tokumo, Y. Yatabe, S. Ichihara, M. Inukai, H. Suehisa, J. Soh, et al. The Impact of Sex and Smoking Status on the Mutational Spectrum of Epidermal Growth Factor Receptor Gene in Non small Cell Lung Cancer Clin. Cancer Res., October 1, 2007; 13(19): 5763 - 5768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Doody, Y. Wang, S. N. Patel, C. Joynes, S. P. Lee, J. Gerlak, R. L. Rolser, Y. Li, P. Steiner, R. Bassi, et al. Inhibitory activity of cetuximab on epidermal growth factor receptor mutations in non small cell lung cancers Mol. Cancer Ther., October 1, 2007; 6(10): 2642 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Suehisa, S. Toyooka, K. Hotta, A. Uchida, J. Soh, Y. Fujiwara, K. Matsuo, M. Ouchida, M. Takata, K. Kiura, et al. Epidermal Growth Factor Receptor Mutation Status and Adjuvant Chemotherapy With Uracil-Tegafur for Adenocarcinoma of the Lung J. Clin. Oncol., September 1, 2007; 25(25): 3952 - 3957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Padron, M. Sato, J. W. Shay, A. F. Gazdar, J. D. Minna, and M. G. Roth Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized Cancer Res., August 15, 2007; 67(16): 7695 - 7702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ogino, H. Kitao, S. Hirano, A. Uchida, M. Ishiai, T. Kozuki, N. Takigawa, M. Takata, K. Kiura, and M. Tanimoto Emergence of Epidermal Growth Factor Receptor T790M Mutation during Chronic Exposure to Gefitinib in a Non Small Cell Lung Cancer Cell Line Cancer Res., August 15, 2007; 67(16): 7807 - 7814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Seike, N. Yanaihara, E. D. Bowman, K. A. Zanetti, A. Budhu, K. Kumamoto, L. E. Mechanic, S. Matsumoto, J. Yokota, T. Shibata, et al. Use of a Cytokine Gene Expression Signature in Lung Adenocarcinoma and the Surrounding Tissue as a Prognostic Classifier J Natl Cancer Inst, August 15, 2007; 99(16): 1257 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-K. Wong HKI-272 in Non Small Cell Lung Cancer Clin. Cancer Res., August 1, 2007; 13(15): 4593s - 4596s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Bonomi, L. Buckingham, and J. Coon Selecting Patients for Treatment with Epidermal Growth Factor Tyrosine Kinase Inhibitors Clin. Cancer Res., August 1, 2007; 13(15): 4606s - 4612s. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Haussmann Smoking and Lung Cancer: Future Research Directions International Journal of Toxicology, July 1, 2007; 26(4): 353 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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K. E. Finberg, L. V. Sequist, V. A. Joshi, A. Muzikansky, J. M. Miller, M. Han, J. Beheshti, L. R. Chirieac, E. J. Mark, and A. J. Iafrate Mucinous Differentiation Correlates with Absence of EGFR Mutation and Presence of KRAS Mutation in Lung Adenocarcinomas with Bronchioloalveolar Features J. Mol. Diagn., July 1, 2007; 9(3): 320 - 326. [Abstract] [Full Text] [PDF]
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|
|
|
|
C. Gridelli, M. A. Bareschino, C. Schettino, A. Rossi, P. Maione, and F. Ciardiello Erlotinib in Non-Small Cell Lung Cancer Treatment: Current Status and Future Development Oncologist, July 1, 2007; 12(7): 840 - 849. [Abstract] [Full Text] [PDF]
|
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M. Mounawar, A. Mukeria, F. Le Calvez, R. J. Hung, H. Renard, A. Cortot, C. Bollart, D. Zaridze, P. Brennan, P. Boffetta, et al. Patterns of EGFR, HER2, TP53, and KRAS Mutations of p14arf Expression in Non-Small Cell Lung Cancers in Relation to Smoking History Cancer Res., June 15, 2007; 67(12): 5667 - 5672. [Abstract] [Full Text] [PDF]
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