© 2004 by Oxford University Press
© 2004 Oxford University Press
ARTICLE |
Evidence for an Association Between Chlamydia psittaci and Ocular Adnexal Lymphomas
Affiliations of authors: Departments of Radiochemotherapy (AJMF, SD, EV), Pathology (MP, EDC, MF), Ophthalmology (CDC), and Hematology (KF) and Laboratorio di Diagnostica e Ricerca (RI), San Raffaele H Scientific Institute, Milan, Italy; Immunovirology and Biotherapy Unit (MG, LC, AAL, RD) and Division of Experimental Oncology 1 (MB), Department of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
Correspondence to: Andrés J.M. Ferreri, MD, Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy (e-mail: andres.ferreri{at}hsr.it)
Background: Ocular adnexal lymphomas may be antigen-driven disorders; however, the source of the putative antigen or antigens is still unknown. Hence, we assessed whether Chlamydiae infection is associated with the development of ocular adnexal lymphomas. Methods: The presence of Chlamydia psittaci, trachomatis, and pneumoniae DNA was investigated by polymerase chain reaction in 40 ocular adnexal lymphoma samples, 20 nonneoplastic orbital biopsies, 26 reactive lymphadenopathy samples, and peripheral blood mononuclear cells (PBMCs) from 21 lymphoma patients and 38 healthy individuals. Seven patients with chlamydia-positive PBMCs were treated with the antibiotic doxycycline, and objective response was assessed in four patients with measurable lymphoma lesions. Differences in Chlamydiae DNA detection between the case patients and the control subjects were analyzed using the Fisher exact test. All statistical tests were two-sided. Results: Thirty-two of the 40 (80%) ocular adnexal lymphoma samples carried C. psittaci DNA, whereas all lymphoma samples were negative for C. trachomatis and C. pneumoniae. In contrast, none of the 20 nonneoplastic orbital biopsies (0% versus 80%; P<.001) and only three of 26 (12%) reactive lymphadenopathy samples (12% versus 80%; P<.001) carried the C. psittaci DNA. Nine of 21 (43%) patients with chlamydia-positive lymphomas carried C. psittaci DNA in their PBMCs, whereas none (0%) of the healthy PBMC donors carried C. psittaci DNA in their PBMCs (43% versus 0%; P<.001). One month after doxycycline treatment, chlamydial DNA was no longer detectable in the PBMCs of all seven treated patients, and objective response was observed in two of the four evaluable patients. Conclusion: Patients with ocular adnexal lymphoma had a high prevalence of C. psittaci infection in both tumor tissue and PBMCs. Persistent C. psittaci infection may contribute to the development of these lymphomas, as was also supported by the clinical responses observed in this study with C. psittaci–eradicating antibiotic therapy.
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Correspondence about this Article
- Re: Evidence for an Association Between Chlamydia psittaci and Ocular Adnexal Lymphomas
- Patricia de Cremoux, Agathe Subtil, Andrés J. M. Ferreri, Anne Vincent-Salomon, Maruilio Ponzoni, Driss Chaoui, Philippe Arnaud, Livia Lumbroso-Le Rouic, Federico Sacchetti, Rémi Dendale, Martine Thioux, Marie-Christine Escande, Marc-Henri Stern, Riccardo Dolcetti, and Didier Decaudin
J Natl Cancer Inst 2006 98: 365-366.[Extract] [Full Text] [PDF]
Editorial about this Article
- Common Threads of Mucosa-Associated Lymphoid Tissue Lymphoma Pathogenesis: From Infection to Translocation
- Elaine S. Jaffe
J Natl Cancer Inst 2004 96: 571-573.[Extract] [Full Text] [PDF]
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|
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|
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|
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|
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|
|
|
|
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|
|
|
|
|
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|
|
|
|
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|
|
|
|
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|
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|
|
|
|
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|
|
|
|
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|
|
|
|
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|
|
|
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|
|
|
|
|
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