© 2004 by Oxford University Press
© 2004 Oxford University Press
BRIEF COMMUNICATION |
Mammographic Density and Breast Cancer After Ductal Carcinoma In Situ
Affiliations of authors: Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA (LAH, AMC); Department of Health Studies, University of Chicago; Chicago, IL (JJD); National Surgical Adjuvant Breast and Bowel Project (NSABP) Biostatistical Center (JJD, SRL) and Department of Biostatistics (SRL), University of Pittsburgh, Pittsburgh, PA; MSW Consulting, Bloomfield Hills, MI (MS); NSABP Operations Center, Allegheny General Hospital, Pittsburgh, PA (TBJ)
Correspondence to: Laurel A. Habel, PhD, 2000 Broadway, Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612 (e-mail: lah{at}dor.kaiser.org)
Women with ductal carcinoma in situ (DCIS) are at substantially increased risk for a second breast cancer, but few strong predictors for these subsequent tumors have been identified. We used Cox regression modeling to examine the association between mammographic density at diagnosis of DCIS of 504 women from the National Surgical Adjuvant Breast and Bowel Project B-17 trial and risk of subsequent breast cancer events. In this group of patients, mostly 50 years old or older, approximately 6.6% had breasts categorized as highly dense (i.e., 
75% of the breast occupied by dense tissue). After adjusting for treatment with radiotherapy, age, and body mass index, women with highly dense breasts had 2.8 (95% confidence interval [CI] = 1.3 to 6.1) times the risk of subsequent breast cancer (DCIS or invasive), 3.2 (95% CI = 1.2 to 8.5) times the risk of invasive breast cancer, and 3.0 (95% CI = 1.2 to 7.5) times the risk of any ipsilateral breast cancer, compared with women with less than 25% of the breast occupied by dense tissue. Our results provide initial evidence that the risk of second breast cancers may be increased among DCIS patients with highly dense breasts.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. S. Hwang, D. L. Miglioretti, R. Ballard-Barbash, D. L. Weaver, K. Kerlikowske, and for the National Cancer Institute Breast Cancer Su Association between Breast Density and Subsequent Breast Cancer Following Treatment for Ductal Carcinoma In situ Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2587 - 2593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen Electromagnetic Breast Imaging: Results of a Pilot Study in Women with Abnormal Mammograms Radiology, May 1, 2007; 243(2): 350 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Irwin, E. J. Aiello, A. McTiernan, L. Bernstein, F. D. Gilliland, R. N. Baumgartner, K. B. Baumgartner, and R. Ballard-Barbash Physical Activity, Body Mass Index, and Mammographic Density in Postmenopausal Breast Cancer Survivors J. Clin. Oncol., March 20, 2007; 25(9): 1061 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Mitchell, A. C. Antoniou, R. Warren, S. Peock, J. Brown, R. Davies, J. Mattison, M. Cook, I. Warsi, D. G. Evans, et al. Mammographic Density and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers Cancer Res., February 1, 2006; 66(3): 1866 - 1872. [Abstract] [Full Text] [PDF]
|
|