© 2004 by Oxford University Press
© 2004 Oxford University Press
COMMENTARY |
Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations
Affiliations of authors: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (RLP, AK, JWL, AM, JDP); Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA (WCW, DH); Division of Cancer Prevention (PG, VK, JM) and Division of Cancer Epidemiology and Genetics (AS), National Cancer Institute, and Office of Dietary Supplements (EY), National Institutes of Health, Bethesda, MD; Arizona Cancer Center, University of Arizona, Tucson (DA); Department of Preventive Medicine, University of Southern California, Los Angeles (LB); Department of Medicine, University of Toronto, Toronto, Ontario, Canada (NFB); Preventive Medicine and Biometrics, School of Medicine, University of Colorado, Denver (TB); Department of Hematology and Oncology, Ohio State University, Columbus (SKC); Department of Epidemiology and Biostatistics, Loma Linda University, Loma Linda, CA (GF); Department of Mathematics and Computer Sciences, Bar-Ilan University, Tel Aviv, Israel (LF); Department of Epidemiology, Cancer Research Center, University of Hawaii, Honolulu (LNK); Dementia Research Service, Burke Medical Research Institute, White Plains, NY, and Departments of Biochemistry and Neurosciences, Weill Medical College of Cornell University, New York, NY (BSK); San Diego Foundation, San Diego, CA (REP); International Agency for Research on Cancer, Lyon, France (ER); Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, Washington, DC (AY)
Correspondence to: Ross L. Prentice, PhD, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, M3-A410, Seattle, WA 98109-1024 (e-mail: rprentic{at}fhcrc.org)
A shortage of credible information exists on practical dietary and physical activity patterns that have potential to reverse the national obesity epidemic and reduce the risk of major cancers and other chronic diseases. Securing such information is a challenging task, and there is considerable diversity of opinion concerning related research designs and priorities. Here, we put forward some perspectives on useful methodology and infrastructure developments for progress in this important area, and we list high-priority research topics in the areas of 1) assessment of nutrient intake and energy expenditure; 2) development of intermediate outcome biomarkers; 3) enhancement of cohort and cross-cultural studies; and 4) criteria for and development of full-scale nutrition and physical activity intervention trials.
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