© 2004 by Oxford University Press
© 2004 Oxford University Press
ARTICLE |
Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women
Affiliations of authors: Cancer Research UK, Department of Oncology (AMD, CSH, LT, KLN, SO, PDPP, BAJP), European Prospective Investigation of Cancer (RNL, NED), and Cancer Research UK, Genetic Epidemiology Group (DFE), University of Cambridge, Strangeways Research Laboratory, Cambridge, U.K.; Academic Department of Biochemistry, Royal Marsden Hospital, London, U.K. (MD, EF); Queensland Institute for Medical Research, Brisbane, Australia (LK)
Correspondence to: Alison M. Dunning, PhD, Cancer Research UK, Department of Oncology, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN U.K. (e-mail: alisond{at}srl.cam.ac.uk)
Background: Reports suggest a relationship between circulating sex hormone levels and breast cancer risk, but genetic association studies have been inconclusive. We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them. Methods: We assayed circulating levels of estradiol, testosterone, estrone, androstenedione, 17
-hydroxyprogesterone, and sex hormone–binding globulin (SHBG) in 1975 normal postmenopausal women. Fifteen SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were genotyped in these postmenopausal women and in a breast cancer case–control study. Associations of genotypes with breast cancer risk were evaluated in the case–control study and with hormone levels in the postmenopausal women using multiple linear regression with assay batch, body mass index, parity, peri- or postmenopausal status, and age band as covariates. Results: CYP19 SNPs (rs10046 and [TCT]+/–) were associated with differences in estradiol level (P = .0006 and P = .0003, respectively) and the estradiol : testosterone ratio (P = .000001 and P = .002). SNP rs10046 explained 1.6% of the variance (r2) in the estradiol : testosterone ratio. SHBG SNPs (5' untranslated region [5'UTR] g-a and D356N) were associated with both SHBG levels (P<10–6 and P = .005) and the estradiol : SHBG ratio (P = .000008 and P = .01). These SNPs explained 2.4% and 0.6% of the variance in SHBG levels, respectively. SNPs in the other genes were not associated with differences in any hormone levels, and none were statistically significantly associated with breast cancer risk. Conclusion: Genetic variation in CYP19 and SHBG contributes to variance in circulating hormone levels between postmenopausal women, but low r2 values may explain why these genes have given inconclusive results in breast cancer case–control studies.
CiteULike 
Connotea 
Del.icio.us What's this?
Correspondence about this Article
- Re: Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women
- Francisco De Castro, Francisco J. Moron, Luis Montoro, Jose J. Galan, Luis M. Real, and Agustin Ruiz
J Natl Cancer Inst 2005 97: 152-153.[Extract] [Full Text] [PDF]
- RESPONSE: Re: Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women
- Alison M. Dunning, Mitch Dowsett, Catherine S. Healey, Robert N. Luben, Elizabeth Folkerd, Paul D. P. Pharoah, Douglas F. Easton, N. E. Day Bruce, and A. J. Ponder
J Natl Cancer Inst 2005 97: 153-154.[Extract] [Full Text] [PDF]
This article has been cited by other articles:
|
|
 |
|
  R. C. Travis, F. Schumacher, J. N. Hirschhorn, P. Kraft, N. E. Allen, D. Albanes, G. Berglund, S. I. Berndt, H. Boeing, H. B. Bueno-de-Mesquita, et al. CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium Cancer Epidemiol. Biomarkers Prev., October 1, 2009; 18(10): 2734 - 2744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Ding, Y. Song, J. E. Manson, D. J. Hunter, C. C. Lee, N. Rifai, J. E. Buring, J. M. Gaziano, and S. Liu Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Women and Men N. Engl. J. Med., September 17, 2009; 361(12): 1152 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Payne, E. Ingley, I. M. Dick, S. G. Wilson, C. S. Bond, and R. L. Prince In Vitro Kinetic Properties of the Thr201Met Variant of Human Aromatase Gene CYP19A1: Functional Responses to Substrate and Product Inhibition and Enzyme Inhibitors J. Clin. Endocrinol. Metab., August 1, 2009; 94(8): 2998 - 3002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Raskin, F. Lejbkowicz, O. Barnett-Griness, S. Dishon, R. Almog, and G. Rennert BRCA1 Breast Cancer Risk Is Modified by CYP19 Polymorphisms in Ashkenazi Jews Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1617 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Reding, N. S. Weiss, C. Chen, C. I. Li, C. S. Carlson, H.-W. Wilkerson, F. M. Farin, K. E. Thummel, J. R. Daling, and K. E. Malone Genetic Polymorphisms in the Catechol Estrogen Metabolism Pathway and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1461 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Eriksson, M. Lorentzon, L. Vandenput, F. Labrie, M. Lindersson, A.-C. Syvanen, E. S. Orwoll, S. R. Cummings, J. M. Zmuda, O. Ljunggren, et al. Genetic Variations in Sex Steroid-Related Genes as Predictors of Serum Estrogen Levels in Men J. Clin. Endocrinol. Metab., March 1, 2009; 94(3): 1033 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Setiawan, J. A. Doherty, X.-o. Shu, M. R. Akbari, C. Chen, I. De Vivo, A. DeMichele, M. Garcia-Closas, M. T. Goodman, C. A. Haiman, et al. Two Estrogen-Related Variants in CYP19A1 and Endometrial Cancer Risk: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 242 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Freedman, J. Ahn, L. Hou, J. Lissowska, W. Zatonski, M. Yeager, S. J. Chanock, W. H. Chow, and C. C. Abnet Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer Carcinogenesis, January 1, 2009; 30(1): 71 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, L. C. Sakoda, J. A. Doherty, M. M. Loomis, S. Fish, R. M. Ray, M. G. Lin, W. Fan, L. P. Zhao, D. L. Gao, et al. Genetic Variation in CYP19A1 and Risk of Breast Cancer and Fibrocystic Breast Conditions among Women in Shanghai, China Cancer Epidemiol. Biomarkers Prev., December 1, 2008; 17(12): 3457 - 3466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Thompson, C. S. Healey, C. Baynes, B. Kalmyrzaev, S. Ahmed, M. Dowsett, E. Folkerd, R. N. Luben, D. Cox, D. Ballinger, et al. Identification of Common Variants in the SHBG Gene Affecting Sex Hormone-Binding Globulin Levels and Breast Cancer Risk in Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., December 1, 2008; 17(12): 3490 - 3498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hamaguchi, M. Nishio, T. Toyama, H. Sugiura, N. Kondo, Y. Fujii, and H. Yamashita Possible Difference in Frequencies of Genetic Polymorphisms of Estrogen Receptor {alpha}, Estrogen Metabolism and P53 Genes Between Estrogen Receptor-positive and -negative Breast Cancers Jpn. J. Clin. Oncol., November 1, 2008; 38(11): 734 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Crandall, M. Guan, G. A. Laughlin, G. A. Ursin, F. Z. Stanczyk, S. A. Ingles, E. Barrett-Connor, and G. A. Greendale Increases in Serum Estrone Sulfate Level Are Associated with Increased Mammographic Density during Menopausal Hormone Therapy Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1674 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Diergaarde, J. D. Potter, E. R. Jupe, S. Manjeshwar, C. D. Shimasaki, T. W. Pugh, D. C. DeFreese, B. A. Gramling, I. Evans, and E. White Polymorphisms in Genes Involved in Sex Hormone Metabolism, Estrogen Plus Progestin Hormone Therapy Use, and Risk of Postmenopausal Breast Cancer Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1751 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Czajka-Oraniec, W. Zgliczynski, A. Kurylowicz, M. Mikula, and J. Ostrowski Association between gynecomastia and aromatase (CYP19) polymorphisms Eur. J. Endocrinol., May 1, 2008; 158(5): 721 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mendoza, F. J. Moron, F. Quereda, F. Vazquez, M. C. Rivero, T. Martinez-Astorquiza, L. M. Real, R. Sanchez-Borrego, A. Gonzalez-Perez, and A. Ruiz A Digenic Combination of Polymorphisms Within ESR1 and ESR2 Genes Are Associated With Age at Menarche in the Spanish Population Reproductive Sciences, March 1, 2008; 15(3): 305 - 311. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Turk, P. Kopp, L. A. Colangelo, M. Urbanek, K. Wood, K. Liu, H. G. Skinner, and S. M. Gapstur Associations of Serum Sex Hormone Binding Globulin (SHBG) Levels with SHBG Gene Polymorphisms in the CARDIA Male Hormone Study Am. J. Epidemiol., February 15, 2008; 167(4): 412 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Colomer, M. Monzo, I. Tusquets, J. Rifa, J. M. Baena, A. Barnadas, L. Calvo, F. Carabantes, C. Crespo, M. Munoz, et al. A Single-Nucleotide Polymorphism in the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor Letrozole in Advanced Breast Carcinoma Clin. Cancer Res., February 1, 2008; 14(3): 811 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Beesley, S. J. Jordan, A. B. Spurdle, H. Song, S. J. Ramus, S. K. Kjaer, E. Hogdall, R. A. DiCioccio, V. McGuire, A. S. Whittemore, et al. Association Between Single-Nucleotide Polymorphisms in Hormone Metabolism and DNA Repair Genes and Epithelial Ovarian Cancer: Results from Two Australian Studies and an Additional Validation Set Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2557 - 2565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Setiawan, F. R. Schumacher, C. A. Haiman, D. O. Stram, D. Albanes, D. Altshuler, G. Berglund, J. Buring, E. E. Calle, F. Clavel-Chapelon, et al. CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2237 - 2246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ramirez-Lorca, A. Grilo, M. T. Martinez-Larrad, L. Manzano, F. J. Serrano-Hernando, F. J. Moron, V. Perez-Gonzalez, J. L. Gonzalez-Sanchez, J. Fresneda, R. Fernandez-Parrilla, et al. Sex and Body Mass Index Specific Regulation of Blood Pressure by CYP19A1 Gene Variants Hypertension, November 1, 2007; 50(5): 884 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-F. Chan, M. Dowsett, E. Folkerd, S. Bingham, N. Wareham, R. Luben, A. Welch, and K.-T. Khaw Usual Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: The European Prospective Investigation into Cancer-Norfolk Population Study Cancer Epidemiol. Biomarkers Prev., May 1, 2007; 16(5): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Tao, Q. Cai, Z.-F. Zhang, W.-H. Xu, N. Kataoka, W. Wen, Y.-B. Xiang, W. Zheng, and X. O. Shu Polymorphisms in the CYP19A1 (Aromatase) Gene and Endometrial Cancer Risk in Chinese Women Cancer Epidemiol. Biomarkers Prev., May 1, 2007; 16(5): 943 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Low, A. M. Dunning, M. Dowsett, E. Folkerd, D. Doody, J. Taylor, A. Bhaniani, R. Luben, K.-T. Khaw, N. J. Wareham, et al. Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants Cancer Epidemiol. Biomarkers Prev., May 1, 2007; 16(5): 1009 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Haiman, L. Dossus, V. W. Setiawan, D. O. Stram, A. M. Dunning, G. Thomas, M. J. Thun, D. Albanes, D. Altshuler, E. Ardanaz, et al. Genetic Variation at the CYP19A1 Locus Predicts Circulating Estrogen Levels but not Breast Cancer Risk in Postmenopausal Women Cancer Res., March 1, 2007; 67(5): 1893 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Olson, E. V. Bandera, and I. Orlow Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer: A HuGE Review Am. J. Epidemiol., February 1, 2007; 165(3): 235 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Paracchini, S. Raimondi, I. T. Gram, D. Kang, N. A. Kocabas, V. N. Kristensen, D. Li, F. F. Parl, T. Rylander-Rudqvist, P. Soucek, et al. Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer: A HuGE-GSEC Review Am. J. Epidemiol., January 15, 2007; 165(2): 115 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Berndt, N. Chatterjee, W.-Y. Huang, S. J. Chanock, R. Welch, E. D. Crawford, and R. B. Hayes Variant in Sex Hormone-Binding Globulin Gene and the Risk of Prostate Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 165 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Tao, Q. Cai, W. H. Xu, N. Kataoka, W. Wen, W. Zheng, Y. B. Xiang, Z.-F. Zhang, and X. O. Shu Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Endometrial Cancer Risk in Chinese Women Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2570 - 2573. [Full Text] [PDF]
|
|
|
|
|
|
A. L. Eriksson, M. Lorentzon, D. Mellstrom, L. Vandenput, C. Swanson, N. Andersson, G. L. Hammond, J. Jakobsson, A. Rane, E. S. Orwoll, et al. SHBG Gene Promoter Polymorphisms in Men Are Associated with Serum Sex Hormone-Binding Globulin, Androgen and Androgen Metabolite Levels, and Hip Bone Mineral Density J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5029 - 5037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Long, N. Kataoka, X.-O. Shu, W. Wen, Y.-T. Gao, Q. Cai, and W. Zheng Genetic Polymorphisms of the CYP19A1 Gene and Breast Cancer Survival. Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2115 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Setiawan, C. A. Haiman, F. Z. Stanczyk, L. Le Marchand, and B. E. Henderson Racial/Ethnic differences in postmenopausal endogenous hormones: the multiethnic cohort study. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1849 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Low, A. M. Dunning, M. Dowsett, R. N. Luben, K.-T. Khaw, N. J. Wareham, and S. A. Bingham Implications of Gene-Environment Interaction in Studies of Gene Variants in Breast Cancer: An Example of Dietary Isoflavones and the D356N Polymorphism in the Sex Hormone-Binding Globulin Gene. Cancer Res., September 15, 2006; 66(18): 8980 - 8983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Warren, J. Skinner, E. Sala, E. Denton, M. Dowsett, E. Folkerd, C. S. Healey, A. Dunning, D. Doody, B. Ponder, et al. Associations among Mammographic Density, Circulating Sex Hormones, and Polymorphisms in Sex Hormone Metabolism Genes in Postmenopausal Women. Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1502 - 1508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kataoka, R. Warren, R. Luben, J. Camus, E. Denton, E. Sala, N. Day, and K.-T. Khaw How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography? Am. J. Roentgenol., July 1, 2006; 187(1): 73 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Kelloff, S. M. Lippman, A. J. Dannenberg, C. C. Sigman, H. L. Pearce, B. J. Reid, E. Szabo, V. C. Jordan, M. R. Spitz, G. B. Mills, et al. Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer--A Plan to Move Forward Clin. Cancer Res., June 15, 2006; 12(12): 3661 - 3697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Cribb, M. J. Knight, D. Dryer, J. Guernsey, K. Hender, M. Tesch, and T. M. Saleh Role of polymorphic human cytochrome p450 enzymes in estrone oxidation. Cancer Epidemiol. Biomarkers Prev., March 1, 2006; 15(3): 551 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nitsch, M. Molokhia, L. Smeeth, B. L. DeStavola, J. C. Whittaker, and D. A. Leon Limits to Causal Inference based on Mendelian Randomization: A Comparison with Randomized Controlled Trials Am. J. Epidemiol., March 1, 2006; 163(5): 397 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Gann, A. S. Geiger, I. B. Helenowski, E. F. Vonesh, and R. T. Chatterton Estrogen and Progesterone Levels in Nipple Aspirate Fluid of Healthy Premenopausal Women: Relationship to Steroid Precursors and Response Proteins Cancer Epidemiol. Biomarkers Prev., January 1, 2006; 15(1): 39 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. X. Ma, A. A. Adjei, O. E. Salavaggione, J. Coronel, L. Pelleymounter, L. Wang, B. W. Eckloff, D. Schaid, E. D. Wieben, A. A. Adjei, et al. Human Aromatase: Gene Resequencing and Functional Genomics Cancer Res., December 1, 2005; 65(23): 11071 - 11082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-L. Low, J. I. Taylor, P. B. Grace, M. Dowsett, E. Folkerd, D. Doody, A. M. Dunning, S. Scollen, A. A. Mulligan, A. A. Welch, et al. Polymorphisms in the CYP19 Gene May Affect the Positive Correlations between Serum and Urine Phytoestrogen Metabolites and Plasma Androgen Concentrations in Men J. Nutr., November 1, 2005; 135(11): 2680 - 2686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Starr, C. Chen, D. R. Doody, L. Hsu, S. Ricks, N. S. Weiss, and S. M. Schwartz Risk of Testicular Germ Cell Cancer in Relation to Variation in Maternal and Offspring Cytochrome P450 Genes Involved in Catechol Estrogen Metabolism Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2183 - 2190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C E Schuit, F. H de Jong, L. Stolk, W N. H Koek, J. B J van Meurs, M. W C J Schoofs, M C. Zillikens, A. Hofman, J. P T M van Leeuwen, H. A P Pols, et al. Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women Eur. J. Endocrinol., August 1, 2005; 153(2): 327 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Small, M. Marcus, S. L. Sherman, A. K. Sullivan, A. K. Manatunga, and H. S. Feigelson CYP17 genotype predicts serum hormone levels among pre-menopausal women Hum. Reprod., August 1, 2005; 20(8): 2162 - 2167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lurie, G. Maskarinec, R. Kaaks, F. Z. Stanczyk, and L. Le Marchand Association of Genetic Polymorphisms with Serum Estrogens Measured Multiple Times During a 2-Year Period in Premenopausal Women Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1521 - 1527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Z. Ring, C. N. Lessov, T. Reed, R. Marcus, L. Holloway, G. E. Swan, and D. Carmelli Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3653 - 3658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cui, X.-O. Shu, Q. Cai, F. Jin, J.-R. Cheng, H. Cai, Y.-T. Gao, and W. Zheng Association of Breast Cancer Risk with a Common Functional Polymorphism (Asp327Asn) in the Sex Hormone-Binding Globulin Gene Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1096 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Johnson, J. Houck, and C. Chen Screening for Deleterious Nonsynonymous Single-Nucleotide Polymorphisms in Genes Involved in Steroid Hormone Metabolism and Response Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1326 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.A. Hefler, C. Grimm, G. Heinze, C. Schneeberger, M.W. Mueller, A. Muendlein, J.C. Huber, S. Leodolter, and C.B. Tempfer Estrogen-metabolizing gene polymorphisms and age at natural menopause in Caucasian women Hum. Reprod., May 1, 2005; 20(5): 1422 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Haiman, S. E. Riley, M. L. Freedman, V. W. Setiawan, D. V. Conti, and L. Le Marchand Common Genetic Variation in the Sex Steroid Hormone-Binding Globulin (SHBG) Gene and Circulating SHBG Levels among Postmenopausal Women: The Multiethnic Cohort J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2198 - 2204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wen, Q. Cai, X.-O. Shu, J.-R. Cheng, F. Parl, L. Pierce, Y.-T. Gao, and W. Zheng Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Breast Cancer Risk in Chinese Women: Results from the Shanghai Breast Cancer Study and a Meta-analysis Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 329 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Dunning, M. Dowsett, C. S. Healey, R. N. Luben, E. Folkerd, P. D. P. Pharoah, D. F. Easton, N. E. D. Bruce, and A. J. Ponder RESPONSE: Re: Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women J Natl Cancer Inst, January 19, 2005; 97(2): 153 - 154. [Full Text] [PDF]
|
|
|
|
|
|
F. De Castro, F. J. Moron, L. Montoro, J. J. Galan, L. M. Real, and A. Ruiz Re: Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women J Natl Cancer Inst, January 19, 2005; 97(2): 152 - 153. [Full Text] [PDF]
|
|
|
|
 |
|
 B.A.J. PONDER, A. ANTONIOU, A. DUNNING, D.F. EASTON, and P.D.P. PHAROAH Polygenic Inherited Predisposition to Breast Cancer Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 35 - 41. [Abstract] [PDF]
|
|
|
|
|
|
Y.-L. Low, J. I. Taylor, P. B. Grace, M. Dowsett, S. Scollen, A. M. Dunning, A. A. Mulligan, A. A. Welch, R. N. Luben, K.-T. Khaw, et al. Phytoestrogen Exposure Correlation with Plasma Estradiol in Postmenopausal Women in European Prospective Investigation of Cancer and Nutrition-Norfolk May Involve Diet-Gene Interactions Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 213 - 220. [Abstract] [Full Text] [PDF]
|
|