© 2003 by Oxford University Press
Journal of the National Cancer Institute, Vol. 95, No. 7, 556-558,
April 2, 2003
© 2003 Oxford University Press
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Mammographic Breast Density and Family History of Breast Cancer
Affiliations of authors: E. Ziv (Division of General Internal Medicine and Department of Medicine), J. Shepherd (Department of Radiology), R. Smith-Bindman (Departments of Medicine and Radiology), K. Kerlikowske (General Internal Medicine Section, Department of Veterans Affairs and Departments of Medicine and Epidemiology and Biostatistics), University of California, San Francisco.
Correspondence to: Elad Ziv, M.D., UCSF Women’s Health Clinical Research Center, 1635 Divisadero St., Suite 600, San Francisco, CA 94115 (e-mail: eziv{at}itsa.ucsf.edu).
ABSTRACT
The association between mammographic breast density and breast cancer risk may be the result of genetic and/or environmental factors that determine breast density. We reasoned that if the genetic factors that underlie breast density increase breast cancer risk, then breast density should be associated with family history of breast cancer. Therefore, we determined the association between mammographic density and family history of breast cancer among women in the San Francisco Mammography Registry. Mammographic density was classified using the four BI-RADS criteria: 1 = almost entirely fatty, 2 = scattered fibroglandular tissue, 3 = heterogeneously dense, and 4 = extremely dense. We adjusted for age, body mass index, hormone replacement therapy use, menopause status, and personal history of breast cancer. Compared with women with BI-RADS 1 readings, women with higher breast density were more likely to have first-degree relatives with breast cancer (BI-RADS 2, odds ratio [OR] = 1.37, 95% confidence interval [CI] = 0.96 to 1.89; BI-RADS 3, OR = 1.70, 95% CI = 1.19 to 2.40; BI-RADS 4, OR = 1.70, 95% CI = 1.05 to 2.71). Thus, the genetic factors that determine breast density may determine breast cancer risk.
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Correspondence about this Article
- Re: Mammographic Breast Density and Family History of Breast Cancer
- Francois Eisinger
J Natl Cancer Inst 2003 95: 1726.[Extract] [Full Text] [PDF]
- RESPONSE: Re: Mammographic Breast Density and Family History of Breast Cancer
- Elad Ziv, John Shepherd, Rebecca Smith-Bindman, and Karla Kerlikowske
J Natl Cancer Inst 2003 95: 1726-1727.[Extract] [Full Text] [PDF]
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