© 2003 by Oxford University Press
Journal of the National Cancer Institute, Vol. 95, No. 5, 362-372,
March 5, 2003
© 2003 Oxford University Press
ARTICLE |
Chemotherapy for Elderly Patients With Advanced Non-Small-Cell Lung Cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) Phase III Randomized Trial
For the MILES Investigators
Correspondence to: Cesare Gridelli, M.D., c/o Unità Sperimentazioni Cliniche, Istituto Nazionale dei Tumori, Via M. Semmola, 80131 Napoli, Italy (e-mail: cgridelli{at}libero.it).
Background: Vinorelbine prolongs survival and improves quality of life in elderly patients with advanced non-small-cell lung cancer (NSCLC). Some studies have also suggested that gemcitabine is well tolerated and effective in such patients. We compared the effectiveness and toxicity of the combination of vinorelbine plus gemcitabine with those of each drug given alone in an open-label, randomized phase III trial in elderly patients with advanced NSCLC. Methods: Patients aged 70 years and older, enrolled between December 1997 and November 2000, were randomly assigned to receive intravenous vinorelbine (30 mg/m2 of body surface area), gemcitabine (1200 mg/m2), or vinorelbine (25 mg/m2) plus gemcitabine (1000 mg/m2). All treatments were delivered on days 1 and 8 every 3 weeks for a maximum of six cycles. The primary endpoint was survival. Survival curves were drawn using the Kaplan–Meier method and analyzed by the Mantel–Haenszel test. Secondary endpoints were quality of life and toxicity. Results: Of 698 patients available for intention-to-treat analysis, 233 were assigned to receive vinorelbine, 233 to gemcitabine, and 232 to vinorelbine plus gemcitabine. Compared with each single drug, the combination treatment did not improve survival. The hazard ratio of death for patients receiving the combination treatment was 1.17 (95% confidence interval [CI] = 0.95 to 1.44) that of patients receiving vinorelbine and 1.06 (95% CI = 0.86 to 1.29) that of patients receiving gemcitabine. Although quality of life was similar across the three treatment arms, the combination treatment was more toxic than the two drugs given singly. Conclusion: The combination of vinorelbine plus gemcitabine is not more effective than single-agent vinorelbine or gemcitabine in the treatment of elderly patients with advanced NSCLC.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Camerini, C. Valsuani, F. Mazzoni, O. Siclari, C. Puccetti, S. Donati, M. Rondini, G. Tartarelli, P. Puccinelli, F. Di Costanzo, et al. Phase II trial of single-agent oral vinorelbine in elderly (>=70 years) patients with advanced non-small-cell lung cancer and poor performance status Ann. Onc., November 13, 2009; (2009) mdp525v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sakakibara, A. Inoue, S. Sugawara, M. Maemondo, T. Ishida, K. Usui, T. Abe, M. Kanbe, H. Watanabe, Y. Saijo, et al. Randomized phase II trial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with carboplatin for elderly patients with advanced non-small-cell lung cancer Ann. Onc., October 8, 2009; (2009) mdp401v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Pallis, C. Gridelli, J. P. van Meerbeeck, L. Greillier, U. Wedding, D. Lacombe, J. Welch, C. P. Belani, and M. Aapro EORTC Elderly Task Force and Lung Cancer Group and International Society for Geriatric Oncology (SIOG) experts' opinion for the treatment of non-small-cell lung cancer in an elderly population Ann. Onc., August 28, 2009; (2009) mdp360v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Goss, D. Ferry, R. Wierzbicki, S. A. Laurie, J. Thompson, B. Biesma, F. R. Hirsch, M. Varella-Garcia, E. Duffield, O. U. Ataman, et al. Randomized Phase II Study of Gefitinib Compared With Placebo in Chemotherapy-Naive Patients With Advanced Non-Small-Cell Lung Cancer and Poor Performance Status J. Clin. Oncol., May 1, 2009; 27(13): 2253 - 2260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Stinchcombe and M. A. Socinski Current Treatments for Advanced Stage Non-Small Cell Lung Cancer Proceedings of the ATS, April 15, 2009; 6(2): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Ramalingam and F. R. Khuri The Role of the Taxanes in the Treatment of Older Patients with Advanced Stage Non-Small Cell Lung Cancer Oncologist, April 1, 2009; 14(4): 412 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Yano, D. Tani, K. Watanabe, H. Tsukamoto, T. Igarashi, T. Nakamura, and M. Masada Evaluation of Potential Interaction Between Vinorelbine and Clarithromycin Ann. Pharmacother., March 1, 2009; 43(3): 453 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gridelli, P. Maione, and A. Rossi Chemotherapy and Targeted Therapy for Older Patients with Advanced Non-small Cell Lung Cancer ASCO Educational Book, January 1, 2009; 2009(1): 283 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Extermann and H. B. Muss Conducting Clinical Trials for Patients Who Are Frail or Elderly ASCO Educational Book, January 1, 2009; 2009(1): 289 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Berhoune, E. Banu, F. Scotte, P. Prognon, S. Oudard, and B. Bonan Therapeutic Strategy for Treatment of Metastatic Non-Small Cell Lung Cancer Ann. Pharmacother., November 1, 2008; 42(11): 1640 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Crino, F. Cappuzzo, P. Zatloukal, M. Reck, M. Pesek, J. C. Thompson, H. E.R. Ford, F. R. Hirsch, M. Varella-Garcia, S. Ghiorghiu, et al. Gefitinib Versus Vinorelbine in Chemotherapy-Naive Elderly Patients With Advanced Non-Small-Cell Lung Cancer (INVITE): A Randomized, Phase II Study J. Clin. Oncol., September 10, 2008; 26(26): 4253 - 4260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wheatley-Price, K. Ding, L. Seymour, G. M. Clark, and F. A. Shepherd Erlotinib for Advanced Non-Small-Cell Lung Cancer in the Elderly: An Analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21 J. Clin. Oncol., May 10, 2008; 26(14): 2350 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chan, V. Shih, and L. Chew Evolving roles of oncology pharmacists in Singapore: A survey on prescribing patterns of antiemetics for chemotherapy induced nausea and vomiting (CINV) at a cancer centre{dagger} Journal of Oncology Pharmacy Practice, March 1, 2008; 14(1): 23 - 29. [Abstract] [PDF]
|
|
|
|
|
|
C. Gridelli Treatment of Advanced Non Small-Cell Lung Cancer in the Elderly: From Best Supportive Care to the Combination of Platin-Based Chemotherapy and Targeted Therapies J. Clin. Oncol., January 1, 2008; 26(1): 13 - 15. [Full Text] [PDF]
|
|
|
|
|
|
T. R. Asmis, K. Ding, L. Seymour, F. A. Shepherd, N. B. Leighl, T. L. Winton, M. Whitehead, J. N. Spaans, B. C. Graham, and G. D. Goss Age and Comorbidity As Independent Prognostic Factors in the Treatment of Non-Small-Cell Lung Cancer: A Review of National Cancer Institute of Canada Clinical Trials Group Trials J. Clin. Oncol., January 1, 2008; 26(1): 54 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Ramalingam, S. E. Dahlberg, C. J. Langer, R. Gray, C. P. Belani, J. R. Brahmer, A. B. Sandler, J. H. Schiller, and D. H. Johnson Outcomes for Elderly, Advanced-Stage Non Small-Cell Lung Cancer Patients Treated With Bevacizumab in Combination With Carboplatin and Paclitaxel: Analysis of Eastern Cooperative Oncology Group Trial 4599 J. Clin. Oncol., January 1, 2008; 26(1): 60 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, P. Maione, A. Illiano, F. V. Piantedosi, A. Favaretto, A. Bearz, S. F. Robbiati, V. Filipazzi, V. Lorusso, F. Carrozza, et al. Cisplatin Plus Gemcitabine or Vinorelbine for Elderly Patients With Advanced Non Small-Cell Lung Cancer: The MILES-2P Studies J. Clin. Oncol., October 10, 2007; 25(29): 4663 - 4669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, P. Maione, A. Rossi, and F. De Marinis The Role of Bevacizumab in the Treatment of Non-Small Cell Lung Cancer: Current Indications and Future Developments Oncologist, October 1, 2007; 12(10): 1183 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Socinski, R. Crowell, T. E. Hensing, C. J. Langer, R. Lilenbaum, A. B. Sandler, and D. Morris Treatment of Non-small Cell Lung Cancer, Stage IV: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 277S - 289S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, C. Langer, P. Maione, A. Rossi, and S. E. Schild Lung Cancer in the Elderly J. Clin. Oncol., May 10, 2007; 25(14): 1898 - 1907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Novello, P Bruzzi, C Barone, R Buosi, A Masotti, G Michetti, M Fioretti, S Barbera, M Spatafora, L Garetto, et al. Phase III study in stage IV non-small-cell lung cancer patients treated with two courses of cisplatin/gemcitabine followed by a randomization to three additional courses of the same combination or gemcitabine alone Ann. Onc., May 1, 2007; 18(5): 903 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Siu Clinical Trials in the Elderly -- A Concept Comes of Age N. Engl. J. Med., April 12, 2007; 356(15): 1575 - 1576. [Full Text] [PDF]
|
|
|
|
|
|
S. Kudoh In Reply J. Clin. Oncol., April 10, 2007; 25(11): 1446 - 1446. [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, P. Maione, and A. Rossi Single-Agent Chemotherapy for the Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: What Is the Best Drug? J. Clin. Oncol., April 10, 2007; 25(11): 1444 - 1445. [Full Text] [PDF]
|
|
|
|
|
|
A. K. Malani, R. M. Abou-Jawde, J. Singh, and S. A. Taylor Docetaxel As Monotherapy in the Treatment of Advanced Non-Small-Cell Lung Cancer in Elderly Patients J. Clin. Oncol., March 20, 2007; 25(9): 1143 - 1144. [Full Text] [PDF]
|
|
|
|
|
|
D. M. Jackman, B. Y. Yeap, N. I. Lindeman, P. Fidias, M. S. Rabin, J. Temel, A. T. Skarin, M. Meyerson, A. J. Holmes, A. M. Borras, et al. Phase II Clinical Trial of Chemotherapy-Naive Patients >= 70 Years of Age Treated With Erlotinib for Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., March 1, 2007; 25(7): 760 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Langer Mind Your Elders: Therapeutic Implications of Epidermal Growth Factor Receptor Inhibition in Older Patients With Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., March 1, 2007; 25(7): 751 - 753. [Full Text] [PDF]
|
|
|
|
|
|
C. Langer, S. Li, J. Schiller, W. Tester, B. L. Rapoport, and D. H. Johnson Randomized Phase II Trial of Paclitaxel Plus Carboplatin or Gemcitabine Plus Cisplatin in Eastern Cooperative Oncology Group Performance Status 2 Non-Small-Cell Lung Cancer Patients: ECOG 1599 J. Clin. Oncol., February 1, 2007; 25(4): 418 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U Basso, L Fratino, A Brunello, F Lumachi, G. De Salvo, S Lonardi, C Ghiotto, H Koussis, L. Pasetto, and S Monfardini Which benefit from adding gemcitabine to vinorelbine in elderly (>=70 years) women with metastatic breast cancer? Early interruption of a phase II study Ann. Onc., January 1, 2007; 18(1): 58 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Murillo Jr. and J. Koeller Chemotherapy Given Near the End of Life by Community Oncologists for Advanced Non-Small Cell Lung Cancer Oncologist, November 1, 2006; 11(10): 1095 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Weiss, C. Langer, R. Rosell, N. Hanna, F. Shepherd, L. H. Einhorn, B. Nguyen, S. Paul, P. McAndrews, P. A. Bunn Jr, et al. Elderly Patients Benefit From Second-Line Cytotoxic Chemotherapy: A Subset Analysis of a Randomized Phase III Trial of Pemetrexed Compared With Docetaxel in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., September 20, 2006; 24(27): 4405 - 4411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kudoh, K. Takeda, K. Nakagawa, M. Takada, N. Katakami, K. Matsui, T. Shinkai, T. Sawa, I. Goto, H. Semba, et al. Phase III Study of Docetaxel Compared With Vinorelbine in Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904) J. Clin. Oncol., August 1, 2006; 24(22): 3657 - 3663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jatoi, S. Hillman, P. Stella, E. Green, A. Adjei, S. Nair, E. Perez, B. Amin, S. E. Schild, R. Castillo, et al. Should Elderly Non-Small-Cell Lung Cancer Patients Be Offered Elderly-Specific Trials? Results of a Pooled Analysis From the North Central Cancer Treatment Group J. Clin. Oncol., December 20, 2005; 23(36): 9113 - 9119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Maione, F. Perrone, C. Gallo, L. Manzione, F. Piantedosi, S. Barbera, S. Cigolari, F. Rosetti, E. Piazza, S. F. Robbiati, et al. Pretreatment Quality of Life and Functional Status Assessment Significantly Predict Survival of Elderly Patients With Advanced Non--Small-Cell Lung Cancer Receiving Chemotherapy: A Prognostic Analysis of the Multicenter Italian Lung Cancer in the Elderly Study J. Clin. Oncol., October 1, 2005; 23(28): 6865 - 6872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wakelee and C. P. Belani Optimizing First-Line Treatment Options for Patients with Advanced NSCLC Oncologist, October 1, 2005; 10(suppl_3): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Spiro and G. A. Silvestri One Hundred Years of Lung Cancer Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 523 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wasil and S. M. Lichtman Clinical Pharmacology Issues Relevant to the Dosing and Toxicity of Chemotherapy Drugs in the Elderly Oncologist, September 1, 2005; 10(8): 602 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli and F. A. Shepherd Chemotherapy for Elderly Patients With Non-Small Cell Lung Cancer: A Review of the Evidence Chest, August 1, 2005; 128(2): 947 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Chen, R.-P. Perng, J.-F. Shih, C.-M. Tsai, and J. Whang-Peng Chemotherapy for Non-small Cell Lung Cancer in Elderly Patients Chest, July 1, 2005; 128(1): 132 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, M. Aapro, A. Ardizzoni, L. Balducci, F. De Marinis, K. Kelly, T. Le Chevalier, C. Manegold, F. Perrone, R. Rosell, et al. Treatment of Advanced Non-Small-Cell Lung Cancer in the Elderly: Results of an International Expert Panel J. Clin. Oncol., May 1, 2005; 23(13): 3125 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Okamoto, E. Moriyama, S. Fujii, H. Kishi, M. Nomura, E. Goto, C. Kiyofuji, F. Imamura, T. Mori, and M. Matsumoto Phase II Study of Carboplatin-Paclitaxel Combination Chemotherapy in Elderly Patients with Advanced Non-small Cell Lung Cancer Jpn. J. Clin. Oncol., April 1, 2005; 35(4): 188 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Baka, L. Ashcroft, H. Anderson, M. Lind, P. Burt, R. Stout, I. Dowd, D. Smith, P. Lorigan, and N. Thatcher Randomized Phase II Study of Two Gemcitabine Schedules for Patients With Impaired Performance Status (Karnofsky performance status <= 70) and Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., April 1, 2005; 23(10): 2136 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Aapro, C.-H. Kohne, H. J. Cohen, and M. Extermann Never Too Old? Age Should Not Be a Barrier to Enrollment in Cancer Clinical Trials Oncologist, March 1, 2005; 10(3): 198 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Stuckler, J. Singhal, S. S. Singhal, S. Yadav, Y. C. Awasthi, and S. Awasthi RLIP76 Transports Vinorelbine and Mediates Drug Resistance in Non-Small Cell Lung Cancer Cancer Res., February 1, 2005; 65(3): 991 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Lilenbaum, J. E. Herndon II, M. A. List, C. Desch, D. M. Watson, A. A. Miller, S. L. Graziano, M. C. Perry, W. Saville, P. Chahinian, et al. Single-Agent Versus Combination Chemotherapy in Advanced Non-Small-Cell Lung Cancer: The Cancer and Leukemia Group B (study 9730) J. Clin. Oncol., January 1, 2005; 23(1): 190 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Ramsey, N. Howlader, R. D. Etzioni, and B. Donato Chemotherapy Use, Outcomes, and Costs for Older Persons With Advanced Non-Small-Cell Lung Cancer: Evidence From Surveillance, Epidemiology and End Results-Medicare J. Clin. Oncol., December 15, 2004; 22(24): 4971 - 4978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Perrone, M. Di Maio, C. Gallo, C. Gridelli, and For the Multicenter Italian Lung Cancer in the Eld Outcome of Patients With a Performance Status of 2 in the Multicenter Italian Lung Cancer in the Elderly Study (MILES) J. Clin. Oncol., December 15, 2004; 22(24): 5018 - 5020. [Full Text] [PDF]
|
|
|
|
|
|
C. G. Azzoli, D. G. Pfister, D. H. Johnson, and M. R. Somerfield In Reply: J. Clin. Oncol., December 15, 2004; 22(24): 5020 - 5021. [Full Text] [PDF]
|
|
|
|
|
|
M. Aapro Granisetron: An Update on its Clinical Use in the Management of Nausea and Vomiting Oncologist, November 1, 2004; 9(6): 673 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Makrantonakis, E. Galani, and P. G. Harper Non-Small Cell Lung Cancer in the Elderly Oncologist, September 1, 2004; 9(5): 556 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Delbaldo, S. Michiels, N. Syz, J.-C. Soria, T. Le Chevalier, and J.-P. Pignon Benefits of Adding a Drug to a Single-Agent or a 2-Agent Chemotherapy Regimen in Advanced Non-Small-Cell Lung Cancer: A Meta-analysis JAMA, July 28, 2004; 292(4): 470 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M L G Janssen-Heijnen, S Smulders, V E P P Lemmens, F W J M Smeenk, H J A A van Geffen, and J W W Coebergh Effect of comorbidity on the treatment and prognosis of elderly patients with non-small cell lung cancer Thorax, July 1, 2004; 59(7): 602 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Laack, N. Dickgreber, T. Muller, A. Knuth, J. Benk, C. Lorenz, F. Gieseler, H. Durk, W. Engel-Riedel, K. Dalhoff, et al. Randomized Phase III Study of Gemcitabine and Vinorelbine Versus Gemcitabine, Vinorelbine, and Cisplatin in the Treatment of Advanced Non-Small-Cell Lung Cancer: From the German and Swiss Lung Cancer Study Group J. Clin. Oncol., June 15, 2004; 22(12): 2348 - 2356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Park, J. C. Lee, C. H. Kim, B.-Y. Ryoo, and H. T. Kim Gemcitabine and Vinorelbine as Second-line Therapy for Non-small Cell Lung Cancer after Treatment with Paclitaxel plus Platinum Jpn. J. Clin. Oncol., May 1, 2004; 34(5): 245 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, A. Ardizzoni, T. Le Chevalier, C. Manegold, F. Perrone, N. Thatcher, N. van Zandwijk, M. Di Maio, O. Martelli, and F. De Marinis Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel Ann. Onc., March 1, 2004; 15(3): 419 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Spira and D. S. Ettinger Multidisciplinary Management of Lung Cancer N. Engl. J. Med., January 22, 2004; 350(4): 379 - 392. [Full Text] [PDF]
|
|
|
|
|
|
D. G. Pfister, D. H. Johnson, C. G. Azzoli, W. Sause, T. J. Smith, S. Baker Jr, J. Olak, D. Stover, J. R. Strawn, A. T. Turrisi, et al. American Society of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003 J. Clin. Oncol., January 15, 2004; 22(2): 330 - 353. [Full Text] [PDF]
|
|
|
|
|
|
Y. Ohe, S. Niho, R. Kakinuma, K. Kubota, H. Ohmatsu, K. Goto, H. Nokihara, H. Kunitoh, N. Saijo, H. Aono, et al. A phase II study of cisplatin and docetaxel administered as three consecutive weekly infusions for advanced non-small-cell lung cancer in elderly patients Ann. Onc., January 1, 2004; 15(1): 45 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Herbst and P. A. Bunn Jr. Targeting the Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer Clin. Cancer Res., December 1, 2003; 9(16): 5813 - 5824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Balducci Lung Cancer in the Elderly: So Many Patients, So Little Time! CA Cancer J Clin, November 1, 2003; 53(6): 322 - 324. [Full Text] [PDF]
|
|
|
|
|
|
A. Hurria and M. G. Kris Management of Lung Cancer in Older Adults CA Cancer J Clin, November 1, 2003; 53(6): 325 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gridelli, P. Maione, and A. Rossi Corticosteroids Underemployment in Delayed Chemotherapy-Induced Nausea and Emesis With Poor Adherence to American Society of Clinical Oncology Guidelines: Is This a Reasonable Clinical Choice for the Elderly? J. Clin. Oncol., November 1, 2003; 21(21): 4066 - 4067. [Full Text] [PDF]
|
|
|
|
|
|
L. V. Sequist and T. J. Lynch Aggressive Treatment for the Fit Elderly With Non-Small-Cell Lung Cancer? Yes! J. Clin. Oncol., September 1, 2003; 21(17): 3186 - 3188. [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Bunn Jr. and R. Lilenbaum Chemotherapy for Elderly Patients With Advanced Non-Small-Cell Lung Cancer J Natl Cancer Inst, March 5, 2003; 95(5): 341 - 343. [Full Text] [PDF]
|
|