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JNCI Journal of the National Cancer Institute 2003 95(18):1414-1416; doi:10.1093/jnci/djg044
© 2003 by Oxford University Press
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© 2003 Oxford University Press

BRIEF COMMUNICATION

Prospective Study of Serum Vitamin E Levels and Esophageal and Gastric Cancers

Philip R. Taylor, You-Lin Qiao, Christian C. Abnet, Sanford M. Dawsey, Chung S. Yang, Elaine W. Gunter, Wen Wang, William J. Blot, Zhi-Wei Dong, Steven D. Mark

Affiliations of authors: P. R. Taylor, C. C. Abnet, S. M. Dawsey (Center for Cancer Research), S. D. Mark (Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; Y.-L. Qiao, W. Wang, Z.-W. Dong, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, Peoples’ Republic of China; C. S. Yang, Rutgers State University of New Jersey, Piscataway, NJ; E. W. Gunter, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA; W. J. Blot, International Epidemiology Institute, Rockville, MD.

Correspondence to: Philip R. Taylor, MD, ScD, Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Blvd., Rm. 705, Bethesda, MD 20892–8314 (e-mail: ptaylor{at}mail.nih.gov).

ABSTRACT

Participants in the General Population Trial, a randomized nutrition intervention trial in Linxian, China, who received a combination of selenium, {beta}-carotene, and vitamin E supplements, had statistically significantly lower cancer mortality rates than those who did not receive the supplements. In the current study, we used a case–cohort design to examine the association between pre-trial serum vitamin E levels and the risks of developing esophageal and gastric cancers during the trial. We measured serum {alpha}- and {gamma}-tocopherol and cholesterol levels in 1072 case patients with incident esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), or gastric noncardia cancer (GNCC) and in 1053 control subjects. The relative risks for comparisons of the highest to the lowest quartiles of serum {alpha}-tocopherol were 0.63 (95% confidence interval [CI] = 0.44 to 0.91) for ESCC, 0.84 (95% CI = 0.55 to 1.26) for GCC, and 2.05 (95% CI = 0.89 to 4.75) for GNCC. Serum {gamma}-tocopherol level was not associated with the incidence of any of these cancers. Our findings provide support for the role of {alpha}-tocopherol in the etiology of upper gastrointestinal cancers.


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