© 2003 by Oxford University Press
© 2003 Oxford University Press
ARTICLE |
Phytoestrogen Intake and Endometrial Cancer Risk
Affiliations of authors: P. L. Horn-Ross, E. M. John, A. J. Canchola, S. L. Stewart, Northern California Cancer Center, Union City, CA; M. M. Lee, Department of Epidemiology and Biostatistics, University of California, San Francisco.
Correspondence to: Pamela L. Horn-Ross, Ph.D., Northern California Cancer Center, 32960 Alvarado-Niles Rd., Suite 600, Union City, CA 94587 (e-mail: phornros{at}nccc.org).
Background: The development of endometrial cancer is largely related to prolonged exposure to unopposed estrogens. Phytoestrogens (i.e., weak estrogens found in plant foods) may have antiestrogenic effects. We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer. Methods: In a case–control study from the greater San Francisco Bay Area, we collected dietary information from 500 African American, Latina, and white women aged 35–79 years who were diagnosed with endometrial cancer between 1996 and 1999 and from 470 age- and ethnicity-matched control women identified through random-digit dialing. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Isoflavone (OR = 0.59, 95% CI = 0.37 to 0.93 for the highest versus lowest quartile of exposure) and lignan (OR = 0.68, 95% CI = 0.44 to 1.1) consumptions were inversely related to the risk of endometrial cancer. These associations were slightly stronger in postmenopausal women (OR = 0.44, 95% CI = 0.26 to 0.77 and OR = 0.57, 95% CI = 0.34 to 0.97 for isoflavones and lignans, respectively). Obese postmenopausal women consuming relatively low amounts of phytoestrogens had the highest risk of endometrial cancer (OR = 6.9, 95% CI = 3.3 to 14.5 compared with non-obese postmenopausal women consuming relatively high amounts of isoflavones); however, the interaction between obesity and phytoestrogen intake was not statistically significant. Conclusion: Some phytoestrogenic compounds, at the levels consumed in the typical American-style diet, are associated with reduced risk of endometrial cancer.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Messina and A. H Wu Perspectives on the soy-breast cancer relation Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1673S - 1679S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, I-M. Lee, S. M Zhang, J. B Blumberg, J. E Buring, and H. D Sesso Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women Am. J. Clinical Nutrition, March 1, 2009; 89(3): 905 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Marini, A. Bitto, D. Altavilla, B. P. Burnett, F. Polito, V. Di Stefano, L. Minutoli, M. Atteritano, R. M. Levy, R. D'Anna, et al. Breast Safety and Efficacy of Genistein Aglycone for Postmenopausal Bone Loss: A Follow-Up Study J. Clin. Endocrinol. Metab., December 1, 2008; 93(12): 4787 - 4796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Caserta, L. Maranghi, A. Mantovani, R. Marci, F. Maranghi, and M. Moscarini Impact of endocrine disruptor chemicals in gynaecology Hum. Reprod. Update, January 1, 2008; 14(1): 59 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Xu, Q. Dai, Y. B. Xiang, J. R. Long, Z. X. Ruan, J. R. Cheng, W. Zheng, and X. O. Shu Interaction of Soy Food and Tea Consumption with CYP19A1 Genetic Polymorphisms in the Development of Endometrial Cancer Am. J. Epidemiol., December 15, 2007; 166(12): 1420 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. N. Fink, S. E. Steck, M. S. Wolff, J. A. Britton, G. C. Kabat, M. M. Gaudet, P. E. Abrahamson, P. Bell, J. C. Schroeder, S. L. Teitelbaum, et al. Dietary Flavonoid Intake and Breast Cancer Survival among Women on Long Island Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2285 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Fink, S. E. Steck, M. S. Wolff, J. A. Britton, G. C. Kabat, J. C. Schroeder, S. L. Teitelbaum, A. I. Neugut, and M. D. Gammon Dietary Flavonoid Intake and Breast Cancer Risk among Women on Long Island Am. J. Epidemiol., March 1, 2007; 165(5): 514 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. Setiawan, M. C. Pike, L. N. Kolonel, A. M. Nomura, M. T. Goodman, and B. E. Henderson Racial/Ethnic Differences in Endometrial Cancer Risk: The Multiethnic Cohort Study Am. J. Epidemiol., February 1, 2007; 165(3): 262 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Messina, W. McCaskill-Stevens, and J. W. Lampe Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J Natl Cancer Inst, September 20, 2006; 98(18): 1275 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Sacks, A. Lichtenstein, L. Van Horn, W. Harris, P. Kris-Etherton, M. Winston, and for the American Heart Association Nutrition Commi Soy Protein, Isoflavones, and Cardiovascular Health: An American Heart Association Science Advisory for Professionals From the Nutrition Committee Circulation, February 21, 2006; 113(7): 1034 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Schabath, L. M. Hernandez, X. Wu, P. C. Pillow, and M. R. Spitz Dietary Phytoestrogens and Lung Cancer Risk JAMA, September 28, 2005; 294(12): 1493 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. E. J. Milder, E. J. M. Feskens, I. C. W. Arts, H. B. B. de Mesquita, P. C. H. Hollman, and D. Kromhout Intake of the Plant Lignans Secoisolariciresinol, Matairesinol, Lariciresinol, and Pinoresinol in Dutch Men and Women J. Nutr., May 1, 2005; 135(5): 1202 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Arts and P. C. Hollman Polyphenols and disease risk in epidemiologic studies Am. J. Clinical Nutrition, January 1, 2005; 81(1): 317S - 325S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Wood, T. C. Register, M. S. Anthony, N. D. Kock, and J. M. Cline Breast and Uterine Effects of Soy Isoflavones and Conjugated Equine Estrogens in Postmenopausal Female Monkeys J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3462 - 3468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Xu, W. Zheng, Y. B. Xiang, Z. X. Ruan, J. R. Cheng, Q. Dai, Y. T. Gao, and X. O. Shu Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study BMJ, May 29, 2004; 328(7451): 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Erdman Jr., T. M. Badger, J. W. Lampe, K. D.R. Setchell, and M. Messina Not All Soy Products Are Created Equal: Caution Needed in Interpretation of Research Results J. Nutr., May 1, 2004; 134(5): 1229S - 1233S. [Abstract] [Full Text] [PDF]
|
|