© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 4, 293-299,
February 21, 2001
© 2001 Oxford University Press
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
Affiliations of authors: D. Solomon (Breast and Gynecologic Cancer Research Group, Division of Cancer Prevention), M. Schiffman (Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics), R. Tarone (Biostatistics Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD.
Correspondence to: Diane Solomon, M.D., Executive Plaza North, 6130 Executive Blvd., Rockville, MD 20852 (e-mail: ds87v{at}nih.gov).
Background: More than 2 million U.S. women receive an equivocal cervical cytologic diagnosis (atypical squamous cells of undetermined significance [ASCUS]) each year. Effective colposcopy triage strategies are needed to identify the minority of women who have clinically significant disease while avoiding excessive follow-up evaluation for others. Methods: The ASCUS/LSIL (i.e., low-grade squamous intraepithelial lesion) Triage Study (ALTS) is a multicenter, randomized trial comparing the sensitivity and specificity of the following three management strategies to detect cervical intraepithelial neoplasia grade 3 (CIN3): 1) immediate colposcopy (considered to be the reference standard), 2) triage to colposcopy based on human papillomavirus (HPV) results from Hybrid Capture 2TM (HC 2) and thin-layer cytology results, or 3) triage based on cytology results alone. This article summarizes the cross-sectional enrollment results for 3488 women with a referral diagnosis of ASCUS. All statistical tests are two-sided. Results: Among participants with ASCUS, the underlying prevalence of histologically confirmed CIN3 was 5.1%. Sensitivity to detect CIN3 or above by testing for cancer-associated HPV DNA was 96.3% (95% confidence interval [CI] = 91.6% to 98.8%), with 56.1% of women referred to colposcopy. Sensitivity of a single repeat cytology specimen with a triage threshold of HSIL or above was 44.1% (95% CI = 35.6% to 52.9%), with 6.9% referred. Sensitivity of a lower cytology triage threshold of ASCUS or above was 85.3% (95% CI = 78.2% to 90.8%), with 58.6% referred. Conclusions: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS. It has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.
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|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 D. M. Harper, M. R. Longacre, W. W. Noll, D. R. Belloni, and B. F. Cole Factors Affecting the Detection Rate of Human Papillomavirus Ann. Fam. Med, November 1, 2003; 1(4): 221 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 G Gallo, M Bibbo, L Bagella, A Zamparelli, F Sanseverino, M R Giovagnoli, A Vecchione, and A Giordano Study of viral integration of HPV-16 in young patients with LSIL J. Clin. Pathol., July 1, 2003; 56(7): 532 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Sherman Chapter 11: Future Directions in Cervical Pathology J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 72 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iftner and L. L. Villa Chapter 12: Human Papillomavirus Technologies J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 80 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Franco Chapter 13: Primary Screening of Cervical Cancer With Human Papillomavirus Tests J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 89 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Solomon Chapter 14: Role of Triage Testing in Cervical Cancer Screening J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 97 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Crum, D. W. Abbott, and B. J. Quade Cervical Cancer Screening: From the Papanicolaou Smear to the Vaccine Era J. Clin. Oncol., May 15, 2003; 21(90100): 224s - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, C. Miller, R. Mosher, X. Zhao, J. Deeds, M. Morrissey, B. Bryant, D. Yang, R. Meyer, F. Cronin, et al. Identification of Cervical Cancer Markers by cDNA and Tissue Microarrays Cancer Res., April 15, 2003; 63(8): 1927 - 1935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 E. M. Burd Human Papillomavirus and Cervical Cancer Clin. Microbiol. Rev., January 1, 2003; 16(1): 1 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
K. J. McCaffery, J. Waller, S. Forrest, J. Wardle, G. F. Sawaya, K. Smith-McCune, T. C. Wright, Jr, J. T. Cox, L. S. Massad, L. B. Twiggs, et al. Testing for Human Papillomavirus in Women With Abnormal Pap Smear Results JAMA, September 18, 2002; 288(11): 1350 - 1350. [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Workowski, W. C. Levine, and J. N. Wasserheit U.S. Centers for Disease Control and Prevention Guidelines for the Treatment of Sexually Transmitted Diseases: An Opportunity To Unify Clinical and Public Health Practice Ann Intern Med, August 20, 2002; 137(4): 255 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Calhoun, R. M. McGovern, C. A. Janney, J. R. Cerhan, S. J. Iturria, D. I. Smith, B. S. Gostout, and D. H. Persing Host Genetic Polymorphism Analysis in Cervical Cancer Clin. Chem., August 1, 2002; 48(8): 1218 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Berger, A. Baege, T. Guillemette, J. Deeds, R. Meyer, G. Disbrow, R. Schlegel, and R. Schlegel Insulin-Like Growth Factor-Binding Protein 3 Expression Increases during Immortalization of Cervical Keratinocytes by Human Papillomavirus Type 16 E6 and E7 Proteins Am. J. Pathol., August 1, 2002; 161(2): 603 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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T. C. Wright Jr, J. T. Cox, L. S. Massad, L. B. Twiggs, E. J. Wilkinson, and for the 2001 ASCCP-Sponsored Consensus Conference 2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities JAMA, April 24, 2002; 287(16): 2120 - 2129. [Abstract] [Full Text] [PDF]
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M. H. Stoler New Bethesda Terminology and Evidence-Based Management Guidelines for Cervical Cytology Findings JAMA, April 24, 2002; 287(16): 2140 - 2141. [Full Text] [PDF]
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F X Bosch, A Lorincz, N Munoz, C J L M Meijer, and K V Shah The causal relation between human papillomavirus and cervical cancer J. Clin. Pathol., April 1, 2002; 55(4): 244 - 265. [Abstract] [Full Text] [PDF]
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A. J. C. van den Brule, R. Pol, N. Fransen-Daalmeijer, L. M. Schouls, C. J. L. M. Meijer, and P. J. F. Snijders GP5+/6+ PCR followed by Reverse Line Blot Analysis Enables Rapid and High-Throughput Identification of Human Papillomavirus Genotypes J. Clin. Microbiol., March 1, 2002; 40(3): 779 - 787. [Abstract] [Full Text] [PDF]
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P. E. Castle, A. T. Lorincz, I. Mielzynska-Lohnas, D. R. Scott, A. G. Glass, M. E. Sherman, J. E. Schussler, and M. Schiffman Results of Human Papillomavirus DNA Testing with the Hybrid Capture 2 Assay Are Reproducible J. Clin. Microbiol., March 1, 2002; 40(3): 1088 - 1090. [Abstract] [Full Text] [PDF]
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M. E. Sherman, M. Schiffman, and J. T. Cox Effects of Age and Human Papilloma Viral Load on Colposcopy Triage: Data From the Randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS) J Natl Cancer Inst, January 16, 2002; 94(2): 102 - 107. [Abstract] [Full Text] [PDF]
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A. R. Giuliano, M. Papenfuss, M. Abrahamsen, C. Denman, J. G. de Zapien, J. L. N. Henze, L. Ortega, E. M. B. de Galaz, J. Stephan, J. Feng, et al. Human Papillomavirus Infection at the United States-Mexico Border: Implications for Cervical Cancer Prevention and Control Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1129 - 1136. [Abstract] [Full Text] [PDF]
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 M. H. Stoler HPV for Cervical Cancer Screening: Is the Era of the Molecular Pap Smear Upon Us? J. Histochem. Cytochem., September 1, 2001; 49(9): 1197 - 1198. [Abstract] [Full Text] [PDF]
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M. Arbyn, H. Van Oyen, E. Lynge, and M. Mickshe European consensus on cancer screening should be applied urgently by health ministers BMJ, August 18, 2001; 323(7309): 396 - 396. [Full Text] [PDF]
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J. E. Harris Re: Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial J Natl Cancer Inst, June 20, 2001; 93(12): 950 - 950. [Full Text] [PDF]
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H. Strickler and K. Shah Re: Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial J Natl Cancer Inst, June 20, 2001; 93(12): 951 - 951. [Full Text] [PDF]
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D. Solomon and M. Schiffman RESPONSE: Re: Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial J Natl Cancer Inst, June 20, 2001; 93(12): 951a - 952a. [Full Text] [PDF]
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E. A. Holly, M. L. Ralston, T. M. Darragh, R. M. Greenblatt, N. Jay, and J. M. Palefsky Prevalence and Risk Factors for Anal Squamous Intraepithelial Lesions in Women J Natl Cancer Inst, June 6, 2001; 93(11): 843 - 849. [Abstract] [Full Text] [PDF]
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G. F. Sawaya, A. D. Brown, A. E. Washington, and A. M. Garber Current Approaches to Cervical-Cancer Screening N. Engl. J. Med., May 24, 2001; 344(21): 1603 - 1607. [Full Text] [PDF]
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M M. Manos HPV testing for clarifying borderline cervical smear results BMJ, April 14, 2001; 322(7291): 878 - 879. [Full Text]
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 HPV DNA Testing Useful When Pap Smears Are Equivocal Journal Watch Women's Health, April 3, 2001; 2001(403): 4 - 4. [Full Text]
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 HPV DNA Testing Useful When Pap Smears Are Equivocal Journal Watch (General), March 23, 2001; 2001(323): 2 - 2. [Full Text]
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H. z. Hausen Cervical Carcinoma and Human Papillomavirus: On the Road to Preventing a Major Human Cancer J Natl Cancer Inst, February 21, 2001; 93(4): 252 - 253. [Full Text] [PDF]
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