© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 21, 1603-1614,
November 7, 2001
© 2001 Oxford University Press
REVIEW |
Retrovirus-Induced Ovine Pulmonary Adenocarcinoma, an Animal Model for Lung Cancer
Affiliations of authors: M. Palmarini, Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens; H. Fan, Cancer Research Institute and Department of Molecular Biology and Biochemistry, University of California, Irvine.
Correspondence to: Massimo Palmarini, D.V.M., Ph.D., Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 (e-mail: mpalmari{at}vet.uga.edu).
Studies on the molecular mechanisms of transformation of retrovirus-induced neoplasms in domestic and laboratory animal species have provided insights into the genetic basis of cancer. Ovine pulmonary adenocarcinoma (OPA) is a retrovirus-induced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. The etiologic agent of OPA, jaagsiekte sheep retrovirus (JSRV), is unique among retroviruses for having a specific tropism for the differentiated epithelial cells of the lung, and it is the only virus known to cause a naturally occurring lung adenocarcinoma. Expression of the JSRV envelope protein is sufficient to induce cell transformation in vitro, possibly via the activation of the phosphatidylinositol 3-kinase/Akt-signaling pathway mediated by the cytoplasmic tail of the transmembrane protein. The aim of this review is to draw the attention of basic and clinical scientists engaged in lung cancer research to this unique animal model, to explore the possible use of OPA as a tool to investigate the mechanisms of pulmonary carcinogenesis, and to underline the similarities between OPA and some forms of human lung adenocarcinoma. The possibility of a viral etiology for the latter will be evaluated in this review.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Nitta, A. Hofacre, S. Hull, and H. Fan Identification and Mutational Analysis of a Rej Response Element in Jaagsiekte Sheep Retrovirus RNA J. Virol., December 1, 2009; 83(23): 12499 - 12511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Murcia, G. Delhon, M. J. Gonzalez, M. Vilas, J. A. Ramos-Vara, M. De Las Heras, R. W. Nordhausen, and F. A. Uzal Cluster of cases of malignant schwannoma in cattle Vet Rec., September 13, 2008; 163(11): 331 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Voisset, R. A. Weiss, and D. J. Griffiths Human RNA "Rumor" Viruses: the Search for Novel Human Retroviruses in Chronic Disease Microbiol. Mol. Biol. Rev., March 1, 2008; 72(1): 157 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Arnaud, P. R. Murcia, and M. Palmarini Mechanisms of Late Restriction Induced by an Endogenous Retrovirus J. Virol., October 15, 2007; 81(20): 11441 - 11451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Caporale, C. Cousens, P. Centorame, C. Pinoni, M. De las Heras, and M. Palmarini Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep. J. Virol., August 1, 2006; 80(16): 8030 - 8037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hull and H. Fan Mutational analysis of the cytoplasmic tail of jaagsiekte sheep retrovirus envelope protein. J. Virol., August 1, 2006; 80(16): 8069 - 8080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Engels, M. V. Brock, J. Chen, C. M. Hooker, M. Gillison, and R. D. Moore Elevated Incidence of Lung Cancer Among HIV-Infected Individuals J. Clin. Oncol., March 20, 2006; 24(9): 1383 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McGee-Estrada and H. Fan In Vivo and In Vitro Analysis of Factor Binding Sites in Jaagsiekte Sheep Retrovirus Long Terminal Repeat Enhancer Sequences: Roles of HNF-3, NF-I, and C/EBP for Activity in Lung Epithelial Cells J. Virol., January 1, 2006; 80(1): 332 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hofacre and H. Fan Multiple Domains of the Jaagsiekte Sheep Retrovirus Envelope Protein Are Required for Transformation of Rodent Fibroblasts J. Virol., October 1, 2004; 78(19): 10479 - 10489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cousens, J. V. Bishop, A. W. Philbey, C. A. Gill, M. Palmarini, J. O. Carlson, J. C. DeMartini, and J. M. Sharp Analysis of Integration Sites of Jaagsiekte Sheep Retrovirus in Ovine Pulmonary Adenocarcinoma J. Virol., August 15, 2004; 78(16): 8506 - 8512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mura, P. Murcia, M. Caporale, T. E. Spencer, K. Nagashima, A. Rein, and M. Palmarini Late viral interference induced by transdominant Gag of an endogenous retrovirus PNAS, July 27, 2004; 101(30): 11117 - 11122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Palmarini, M. Mura, and T. E. Spencer Endogenous betaretroviruses of sheep: teaching new lessons in retroviral interference and adaptation J. Gen. Virol., January 1, 2004; 85(1): 1 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. de Parseval, V. Lazar, J.-F. Casella, L. Benit, and T. Heidmann Survey of Human Genes of Retroviral Origin: Identification and Transcriptome of the Genes with Coding Capacity for Complete Envelope Proteins J. Virol., October 1, 2003; 77(19): 10414 - 10422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-H. Wang, D. Wang, and Y.-Q. Chen Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase Carcinogenesis, August 1, 2003; 24(8): 1291 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-L. Liu, M. I. Lerman, and A. D. Miller Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for Rodent Fibroblast Transformation and PI3K/Akt Activation J. Virol., July 15, 2003; 77(14): 7924 - 7935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. J. Chow, A. Alberti, M. Mura, C. Pretto, P. Murcia, L. M. Albritton, and M. Palmarini Transformation of Rodent Fibroblasts by the Jaagsiekte Sheep Retrovirus Envelope Is Receptor Independent and Does Not Require the Surface Domain J. Virol., June 1, 2003; 77(11): 6341 - 6350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Danilkovitch-Miagkova, F.-M. Duh, I. Kuzmin, D. Angeloni, S.-L. Liu, A. D. Miller, and M. I. Lerman Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus PNAS, April 15, 2003; 100(8): 4580 - 4585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Spencer, M. Mura, C. A. Gray, P. J. Griebel, and M. Palmarini Receptor Usage and Fetal Expression of Ovine Endogenous Betaretroviruses: Implications for Coevolution of Endogenous and Exogenous Retroviruses J. Virol., December 6, 2002; 77(1): 749 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Allen, K. J. Sherrill, S. M. Crispell, M. R. Perrott, J. O. Carlson, and J. C. DeMartini The jaagsiekte sheep retrovirus envelope gene induces transformation of the avian fibroblast cell line DF-1 but does not require a conserved SH2 binding domain J. Gen. Virol., November 1, 2002; 83(11): 2733 - 2742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Alberti, C. Murgia, S.-L. Liu, M. Mura, C. Cousens, M. Sharp, A. D. Miller, and M. Palmarini Envelope-Induced Cell Transformation by Ovine Betaretroviruses J. Virol., May 3, 2002; 76(11): 5387 - 5394. [Abstract] [Full Text] [PDF]
|
|