© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 20, 1563-1568,
October 17, 2001
© 2001 Oxford University Press
|
|
REPORT |
Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study
E. S. Schernhammer, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; F. Laden, F. E. Speizer, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department for Environmental Health, Harvard School of Public Health, Boston; W. C. Willett, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Departments of Epidemiology and Nutrition, Harvard School of Public Health; D. J. Hunter, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, and Harvard Center for Cancer Prevention, Boston; I. Kawachi, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Health and Social Behavior, Harvard School of Public Health; G. A. Colditz, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Departments of Epidemiology and Nutrition, Harvard School of Public Health, and Epidemiology Program, Dana-Faber/Harvard Cancer Center, Boston.
Correspondence to: Eva S. Schernhammer, M.D., M.P.H., Channing Laboratory, 181 Longwood Ave., Boston, MA 02115 (e-mail: eva.schernhammer{at}channing.harvard.edu).Reprint requests to: Graham A. Colditz, M.D., D.P.H., Nurses' Health Study, Channing Laboratory, 181 Longwood Ave., Boston, MA 02115.
Background: Melatonin shows potential oncostatic action, and light exposure during night suppresses melatonin production. There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer. Methods: We examined the relationship between breast cancer and working on rotating night shifts during 10 years of follow-up in 78 562 women from the Nurses' Health Study. Information was ascertained in 1988 about the total number of years during which the nurses had worked rotating night shifts with at least three nights per month. From June 1988 through May 1998, we documented 2441 incident breast cancer cases. Logistic regression models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs), adjusted for confounding variables and breast cancer risk factors. All statistical tests were two-sided. Results: We observed a moderate increase in breast cancer risk among the women who worked 1–14 years or 15–29 years on rotating night shifts (multivariate adjusted RR = 1.08 [95% CI = 0.99 to 1.18] and RR = 1.08 [95% CI = 0.90 to 1.30], respectively). The risk was further increased among women who worked 30 or more years on the night shift (RR = 1.36; 95% CI = 1.04 to 1.78). The test for trend was statistically significant (P = .02). Conclusions: Women who work on rotating night shifts with at least three nights per month, in addition to days and evenings in that month, appear to have a moderately increased risk of breast cancer after extended periods of working rotating night shifts.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Spiegel Losing Sleep Over Cancer J. Clin. Oncol., May 20, 2008; 26(15): 2431 - 2432. [Full Text] [PDF]
|
|
|
|
 |
|
 F Tuchsen, K B Christensen, T Lund, and H Feveile A 15-year prospective study of shift work and disability pension Occup. Environ. Med., April 1, 2008; 65(4): 283 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Miller, E. L. McDearmon, S. Panda, K. R. Hayes, J. Zhang, J. L. Andrews, M. P. Antoch, J. R. Walker, K. A. Esser, J. B. Hogenesch, et al. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation PNAS, February 27, 2007; 104(9): 3342 - 3347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Iurisci, E. Filipski, J. Reinhardt, S. Bach, A. Gianella-Borradori, S. Iacobelli, L. Meijer, and F. Levi Improved Tumor Control through Circadian Clock Induction by Seliciclib, a Cyclin-Dependent Kinase Inhibitor. Cancer Res., November 15, 2006; 66(22): 10720 - 10728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jung and N. Ahmad Melatonin in cancer management: progress and promise. Cancer Res., October 15, 2006; 66(20): 9789 - 9793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kubo, K. Ozasa, K. Mikami, K. Wakai, Y. Fujino, Y. Watanabe, T. Miki, M. Nakao, K. Hayashi, K. Suzuki, et al. Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study Am. J. Epidemiol., September 15, 2006; 164(6): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T BROPHY, M. M KEITH, K. M GOREY, I. LUGINAAH, E. LAUKKANEN, D. HELLYER, A. REINHARTZ, A. WATTERSON, H. ABU-ZAHRA, E. MATICKA-TYNDALE, et al. Occupation and breast cancer: a canadian case-control study. Ann. N.Y. Acad. Sci., September 1, 2006; 1076: 765 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. O'Leary, E. R. Schoenfeld, R. G. Stevens, G. C. Kabat, K. Henderson, R. Grimson, M. D. Gammon, M. C. Leske, and for the Electromagnetic Fields and Breast Cancer o Shift Work, Light at Night, and Breast Cancer on Long Island, New York Am. J. Epidemiol., August 15, 2006; 164(4): 358 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Arendt, B. Middleton, P. Williams, G. Francis, and C. Luke Sleep and Circadian Phase in a Ship's Crew. J Biol Rhythms, June 1, 2006; 21(3): 214 - 221. [Abstract] [PDF]
|
|
|
|
|
|
S. P. Pinheiro, E. S. Schernhammer, S. S. Tworoger, and K. B. Michels A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women. Cancer Res., May 15, 2006; 66(10): 5521 - 5525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, E. Schernhammer, M. A. Schwarzschild, and A. Ascherio A Prospective Study of Night Shift Work, Sleep Duration, and Risk of Parkinson's Disease Am. J. Epidemiol., April 15, 2006; 163(8): 726 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Blask, G. C. Brainard, R. T. Dauchy, J. P. Hanifin, L. K. Davidson, J. A. Krause, L. A. Sauer, M. A. Rivera-Bermudez, M. L. Dubocovich, S. A. Jasser, et al. Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats Cancer Res., December 1, 2005; 65(23): 11174 - 11184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Knight, S. Thompson, J. M. Raboud, and B. R. Hoffman Light and Exercise and Melatonin Production in Women Am. J. Epidemiol., December 1, 2005; 162(11): 1114 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Verkasalo, K. Lillberg, R. G. Stevens, C. Hublin, M. Partinen, M. Koskenvuo, and J. Kaprio Sleep Duration and Breast Cancer: A Prospective Cohort Study Cancer Res., October 15, 2005; 65(20): 9595 - 9600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Erren RE: "OCCUPATIONAL MAGNETIC FIELDS AND FEMALE BREAST CANCER: A CASE-CONTROL STUDY USING SWEDISH POPULATION REGISTERS AND NEW EXPOSURE DATA" Am. J. Epidemiol., August 15, 2005; 162(4): 392 - 393. [Full Text] [PDF]
|
|
|
|
|
|
U. M. Forssen, L. E. Rutqvist, A. Ahlbom, and M. Feychting THE AUTHORS REPLY Am. J. Epidemiol., August 15, 2005; 162(4): 393 - 394. [Full Text] [PDF]
|
|
|
|
|
|
V. L. Revell and C. I. Eastman How to Trick Mother Nature into Letting You Fly Around or Stay Up All Night J Biol Rhythms, August 1, 2005; 20(4): 353 - 365. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Gauger and A. Sancar Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer Cancer Res., August 1, 2005; 65(15): 6828 - 6834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Schernhammer and S. E. Hankinson Urinary Melatonin Levels and Breast Cancer Risk J Natl Cancer Inst, July 20, 2005; 97(14): 1084 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mahmoud, N. Sarhill, and M. A. Mazurczak The therapeutic application of melatonin in supportive care and palliative medicine American Journal of Hospice and Palliative Medicine, July 1, 2005; 22(4): 295 - 309. [Abstract] [PDF]
|
|
|
|
 |
|
 S.-T. Chen, K.-B. Choo, M.-F. Hou, K.-T. Yeh, S.-J. Kuo, and J.-G. Chang Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers Carcinogenesis, July 1, 2005; 26(7): 1241 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Filipski, P. F. Innominato, M. Wu, X.-M. Li, S. Iacobelli, L.-J. Xian, and F. Levi Effects of Light and Food Schedules on Liver and Tumor Molecular Clocks in Mice J Natl Cancer Inst, April 6, 2005; 97(7): 507 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhu, H. N. Brown, Y. Zhang, R. G. Stevens, and T. Zheng Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 268 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Filipski, F. Delaunay, V. M. King, M.-W. Wu, B. Claustrat, A. Grechez-Cassiau, C. Guettier, M. H. Hastings, and L. Francis Effects of Chronic Jet Lag on Tumor Progression in Mice Cancer Res., November 1, 2004; 64(21): 7879 - 7885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Parikh, A. Taukari, and T. Bhattacharya Occupational Stress and Coping among Nurses Journal of Health Management, October 1, 2004; 6(2): 115 - 127. [Abstract] [PDF]
|
|
|
|
 |
|
 B. del Rio, J. M. G. Pedrero, C. Martinez-Campa, P. Zuazua, P. S. Lazo, and S. Ramos Melatonin, an Endogenous-specific Inhibitor of Estrogen Receptor {alpha} via Calmodulin J. Biol. Chem., September 10, 2004; 279(37): 38294 - 38302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Schernhammer, B. Rosner, W. C. Willett, F. Laden, G. A. Colditz, and S. E. Hankinson Epidemiology of Urinary Melatonin in Women and Its Relation to Other Hormones and Night Work Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 936 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-A. Phillips, R. L. Milne, M. L. Friedlander, M. A. Jenkins, M. R.E. McCredie, G. G. Giles, and J. L. Hopper Prognosis of Premenopausal Breast Cancer and Childbirth Prior to Diagnosis J. Clin. Oncol., February 15, 2004; 22(4): 699 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Canaple, T. Kakizawa, and V. Laudet The Days and Nights of Cancer Cells Cancer Res., November 15, 2003; 63(22): 7545 - 7552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B. Presser Race-Ethnic and Gender Differences in Nonstandard Work Shifts Work and Occupations, November 1, 2003; 30(4): 412 - 439. [Abstract] [PDF]
|
|
|
|
 |
|
 D. B. Boyd Integrative Tumor Board: Recurrent Breast Cancer or New Primary? Integr Cancer Ther, September 1, 2003; 2(3): 270 - 272. [PDF]
|
|
|
|
|
|
H. Zeeb, M. Blettner, I. Langner, G. P. Hammer, T. J. Ballard, M. Santaquilani, M. Gundestrup, H. Storm, T. Haldorsen, U. Tveten, et al. Mortality from Cancer and Other Causes among Airline Cabin Attendants in Europe: A Collaborative Cohort Study in Eight Countries Am. J. Epidemiol., July 1, 2003; 158(1): 35 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Wargovich and J. E. Cunningham Diet, Individual Responsiveness and Cancer Prevention J. Nutr., July 1, 2003; 133(7): 2400S - 2403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Schernhammer, F. Laden, F. E. Speizer, W. C. Willett, D. J. Hunter, I. Kawachi, C. S. Fuchs, and G. A. Colditz Night-Shift Work and Risk of Colorectal Cancer in the Nurses' Health Study J Natl Cancer Inst, June 4, 2003; 95(11): 825 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kawakami, M. Kawakami, S. R. Husain, and R. K. Puri Effect of Interleukin (IL)-4 Cytotoxin on Breast Tumor Growth after in Vivo Gene Transfer of IL-4 Receptor {alpha} Chain Clin. Cancer Res., May 1, 2003; 9(5): 1826 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. H. Kavakli and A. Sancar Circadian Photoreception in Humans and Mice Mol. Interv., December 1, 2002; 2(8): 484 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Reddy, M. D. Field, E. S. Maywood, and M. H. Hastings Differential Resynchronisation of Circadian Clock Gene Expression within the Suprachiasmatic Nuclei of Mice Subjected to Experimental Jet Lag J. Neurosci., September 1, 2002; 22(17): 7326 - 7330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Filipski, V. M. King, X. Li, T. G. Granda, M.-C. Mormont, X. Liu, B. Claustrat, M. H. Hastings, and F. Levi Host Circadian Clock as a Control Point in Tumor Progression J Natl Cancer Inst, May 1, 2002; 94(9): 690 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Spiegel and S. Sephton Re: Night Shift Work, Light at Night, and Risk of Breast Cancer J Natl Cancer Inst, April 3, 2002; 94(7): 530 - 530. [Full Text] [PDF]
|
|
|
|
|
|
N. Kerenyi Re: Night Shift Work, Light at Night, and Risk of Breast Cancer J Natl Cancer Inst, April 3, 2002; 94(7): 531 - 532. [Full Text] [PDF]
|
|
|
|
|
|
E. Schernhammer and G. Colditz RESPONSE: Re: Night Shift Work, Light at Night, and Risk of Breast Cancer J Natl Cancer Inst, April 3, 2002; 94(7): 532 - 533. [Full Text] [PDF]
|
|
|
|
|
|
J. Hansen RESPONSE: Re: Night Shift Work, Light at Night, and Risk of Breast Cancer J Natl Cancer Inst, April 3, 2002; 94(7): 533 - 534. [Full Text] [PDF]
|
|
|
|
 |
|
 Night Shift Work: Risk Factor for Breast Cancer? Journal Watch (General), November 6, 2001; 2001(1106): 1 - 1. [Full Text]
|
|
|
|
|
|
J. Hansen Light at Night, Shiftwork, and Breast Cancer Risk J Natl Cancer Inst, October 17, 2001; 93(20): 1513 - 1515. [Full Text] [PDF]
|
|