© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 14, 1088-1095,
July 18, 2001
© 2001 Oxford University Press
REPORT |
Erythrocyte Membrane Fatty Acids and Subsequent Breast Cancer: a Prospective Italian Study
Affiliations of authors: V. Pala, V. Krogh, A. Micheli, S. Sieri, F. Berrino, Unità Operativa di Epidemiologia, Istituto Nazionale per la Cura e lo Studio dei Tumori, Milan, Italy; P. Muti, Department of Social and Preventive Medicine, University at Buffalo, State University of New York at Buffalo; V. Chajès, Laboratoire de Biologie des Tumeurs, Université F. Rabelais, Tours, France; E. Riboli, M. Saadatian, Unit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France.
Correspondence to: Vittorio Krogh, M.D., Unità Operativa di Epidemiologia, Istituto Nazionale per la Cura e lo Studio dei Tumori, Via Venezian 1, 20133 Milan, Italy (e-mail: epic{at}istitutotumori.mi.it).
Background: The relationship between erythrocyte membrane fatty acids and postmenopausal breast cancer risk was analyzed previously only by retrospective studies, which suggested a protective effect of increased saturation index (SI), i.e., the ratio of membrane stearic to oleic acid. We investigated the relationships in a prospective study of hormones, diet, and prediagnostic breast cancer (the ORDET study) conducted in northern Italy. Methods: A total of 4052 postmenopausal women were followed for an average of 5.5 years; 71 cases of invasive breast cancer were identified. For each case subject, two matched control subjects were chosen randomly from among cohort members. The various fatty acids in erythrocyte membranes were measured as a percentage of total fatty acids. Conditional logistic regression analysis evaluated the association between membrane fatty acid composition and breast cancer risk. The SI, which is influenced by the activity of the enzyme delta 9 desaturase (
9-d), was also investigated. All statistical tests were two-sided. Results: Oleic (highest versus lowest tertile of percentage of total fatty acids, odds ratio [OR] = 2.79; 95% confidence interval [CI] = 1.24 to 6.28) and monounsaturated fatty acids (highest to lowest tertile, OR = 5.21; 95% CI = 1.95 to 13.91) were positively associated with breast cancer risk. The SI (highest to lowest tertile, OR = 0.29; 95% CI = 0.13 to 0.64) was inversely associated with breast cancer risk. The analysis suggested an inverse association between total polyunsaturated fatty acids and breast cancer risk, but individual polyunsaturated fatty acids behaved differently. There was no association between saturated fatty acids and breast cancer risk. Conclusions: We have found that monounsaturated fats and SI in erythrocyte membranes are predictors of postmenopausal breast cancer. Both of these variables depend on the activity of the enzyme 9-d. The dietary, metabolic, and hormonal factors acting on 9-d expression and activity and, therefore, on patterns of fatty acid metabolism, should be further investigated as possible determinants of breast cancer.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. R. Ong, A. H. Sims, M. Harvie, M. Chapman, W. B. Dunn, D. Broadhurst, R. Goodacre, M. Wilson, N. Thomas, R. B. Clarke, et al. Biomarkers of Dietary Energy Restriction in Women at Increased Risk of Breast Cancer Cancer Prevention Research, August 1, 2009; 2(8): 720 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Saadatian-Elahi, N. Slimani, V. Chajes, M. Jenab, J. Goudable, C. Biessy, P. Ferrari, G. Byrnes, P. Autier, P. H. Peeters, et al. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition Am. J. Clinical Nutrition, January 1, 2009; 89(1): 331 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Chajes, A. C. M. Thiebaut, M. Rotival, E. Gauthier, V. Maillard, M.-C. Boutron-Ruault, V. Joulin, G. M. Lenoir, and F. Clavel-Chapelon Association between Serum trans-Monounsaturated Fatty Acids and Breast Cancer Risk in the E3N-EPIC Study Am. J. Epidemiol., June 1, 2008; 167(11): 1312 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shannon, I. B King, R. Moshofsky, J. W Lampe, D. Li Gao, R. M Ray, and D. B Thomas Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1090 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuriki, K. Wakai, K. Hirose, K. Matsuo, H. Ito, T. Suzuki, T. Saito, Y. Kanemitsu, T. Hirai, T. Kato, et al. Risk of colorectal cancer is linked to erythrocyte compositions of Fatty acids as biomarkers for dietary intakes of fish, fat, and Fatty acids. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1791 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Chajes, M. Cambot, K. Moreau, G. M. Lenoir, and V. Joulin Acetyl-CoA Carboxylase {alpha} Is Essential to Breast Cancer Cell Survival. Cancer Res., May 15, 2006; 66(10): 5287 - 5294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Terry, J. B. Terry, and T. E. Rohan Long-Chain (n-3) Fatty Acid Intake and Risk of Cancers of the Breast and the Prostate: Recent Epidemiological Studies, Biological Mechanisms, and Directions for Future Research J. Nutr., December 1, 2004; 134(12): 3412S - 3420S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lin, S. M. Zhang, N. R. Cook, I-M. Lee, and J. E. Buring Dietary Fat and Fatty Acids and Risk of Colorectal Cancer in Women Am. J. Epidemiol., November 15, 2004; 160(10): 1011 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Boyd Insulin and Cancer Integr Cancer Ther, December 1, 2003; 2(4): 315 - 329. [Abstract] [PDF]
|
|
|
|
|
|
S. L. Goodstine, T. Zheng, T. R. Holford, B. A. Ward, D. Carter, P. H. Owens, and S. T. Mayne Dietary (n-3)/(n-6) Fatty Acid Ratio: Possible Relationship to Premenopausal but Not Postmenopausal Breast Cancer Risk in U.S. Women J. Nutr., May 1, 2003; 133(5): 1409 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saadatian-Elahi, P. Toniolo, P. Ferrari, J. Goudable, A. Akhmedkhanov, A. Zeleniuch-Jacquotte, and E. Riboli Serum Fatty Acids and Risk of Breast Cancer in a Nested Case-Control Study of the New York University Women's Health Study Cancer Epidemiol. Biomarkers Prev., November 1, 2002; 11(11): 1353 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Dai, X.-o. Shu, F. Jin, Y.-T. Gao, Z.-X. Ruan, and W. Zheng Consumption of Animal Foods, Cooking Methods, and Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 801 - 808. [Abstract] [Full Text] [PDF]
|
|