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JNCI Journal of the National Cancer Institute 2000 92(8):628-635; doi:10.1093/jnci/92.8.628
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 8, 628-635, April 19, 2000
© 2000 Oxford University Press

Stromal Cell-Derived Factor-1 as a Chemoattractant for Follicular Center Lymphoma B Cells

Anna Corcione, Luciano Ottonello, Giuseppe Tortolina, Paola Facchetti, Irma Airoldi, Roberta Guglielmino, Patrizia Dadati, Mauro Truini, Silvano Sozzani, Franco Dallegri, Vito Pistoia

Affiliation of authors: A. Corcione, P. Facchetti, I. Airoldi, R. Guglielmino, V. Pistoia, Laboratory of Oncology, G. Gaslini Institute, Genoa, Italy; L. Ottonello, G. Tortolina, F. Dallegri, Department of Internal Medicine, University of Genoa; P. Dadati, M. Truini, Service of Pathology, S. Martino Hospital, Genoa; S. Sozzani, Department of Immunology, Mario Negri Institute, Milan, Italy.

Correspondence to: Anna Corcione, Ph.D., Laboratory of Oncology, G. Gaslini Institute, Largo G. Gaslini, 5-16148 Genoa, Italy (e-mail: laboncologia{at}ospedale-gaslini.ge.it).

Background: Follicular center lymphoma displays widespread lymph node involvement at diagnosis. The chemoattractants that control the locomotion of follicular center lymphoma B cells have not been established. Stromal cell-derived factor-1 (SDF-1) is a CXC-class chemokine that enhances the migration of normal human B cells and is expressed in peripheral lymphoid tissues. Here we have investigated 1) whether SDF-1 stimulates the in vitro locomotion of follicular center lymphoma B cells and of their presumed normal counterparts (i.e., germinal center B cells) and 2) whether the same cells express SDF-1 transcripts. Methods: B cells were purified by immunomagnetic bead manipulation. Messenger RNA was detected by reverse transcription–polymerase chain reaction. Migration was assessed by the filter and collagen invasion assays. All P values were two sided. Results: Follicular center lymphoma B lymphocytes showed a statistically significant migratory response to 300 ng/mL SDF-1, both in the filter and in the collagen assays (P = .002 for each). Such response was mediated by the SDF-1 receptor, CXCR4. CD40 monoclonal antibody (MAb) and tonsillar germinal center B cells treated with CD40 MAb and recombinant interleukin 4, but not freshly isolated, migrated statistically significantly faster in the presence than in the absence of SDF-1 (P = .002 in both filter and collagen assays). Freshly isolated follicular center lymphoma and germinal center B cells expressed SDF-1 transcripts. Conclusions: This study shows that SDF-1 substantially enhances the migration of follicular center lymphoma B cells but not the migration of freshly purified germinal center B cells. This difference may be related to the extended survival of follicular center lymphoma versus germinal center B cells. SDF-1 produced in follicular center lymphoma lymph nodes may play a role in the local dissemination of tumor cells.


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