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JNCI Journal of the National Cancer Institute 2000 92(6):486-492; doi:10.1093/jnci/92.6.486
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 6, 486-492, March 15, 2000
© 2000 Oxford University Press

REPORTS

Association of Angiogenesis in Lymph Node Metastases With Outcome of Breast Cancer

Anthony J. Guidi, Donald A. Berry, Gloria Broadwater, Marjorie Perloff, Larry Norton, Maurice P. Barcos, Daniel F. Hayes

Affiliations of authors: A. J. Guidi, North Shore Medical Center, Salem, MA; D. A. Berry, The University of Texas M. D. Anderson Cancer Center, Houston; G. Broadwater, Cancer and Leukemia Group B Statistical Center, Durham, NC; M. Perloff, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD; L. Norton, Memorial Sloan-Kettering Cancer Center, New York, NY; M. P. Barcos, Roswell Park Cancer Institute, Buffalo, NY; D. F. Hayes, Breast Cancer Program, Lombardi Cancer Center, Georgetown University, Washington, DC.

Correspondence to: Daniel F. Hayes, M.D., Breast Cancer Program, Lombardi Cancer Center, Georgetown University, 3970 Reservoir Rd., N.W., RB504E, Washington, DC 20007 (e-mail: hayesdf{at}gunet.georgetown.edu).

BACKGROUND: Microvessel density (MVD) is a measure of the extent of new blood vessel growth or angiogenesis, which is required for tumor progression. Increased MVD in primary breast cancers appears to adversely affect disease-free survival and overall survival in patients with breast cancer. However, the clinical implications of angiogenesis in breast cancer metastases have not been well studied. The purpose of this study was to compare intratumoral MVD in primary breast cancer tissues with MVD in axillary lymph node metastases and to evaluate the relationships among primary- and metastatic-tumor MVD, disease-free survival, and overall survival in patients with lymph node-positive, stage II breast cancer who were treated with adjuvant chemotherapy in Cancer and Leukemia Group B Protocol 8082. METHODS: Immunostaining for factor VIII-related antigen was performed on tissue sections from 47 primary tumors and 91 axillary lymph nodes containing metastases from 110 patients with lymph node-positive breast cancer. Sections were examined for the presence or absence of focal areas of relatively intense neovascularization (vascular hot spots), and a quantitative assessment of intratumoral MVD was performed. RESULTS: The presence of vascular hot spots in axillary lymph node metastases, but not primary breast cancers, was associated with statistically significantly decreased disease-free survival (P = .006) and overall survival (P = .004) by univariate analysis. Similarly, increased MVD in metastases, but not in primary tumors, was statistically significantly associated with diminished overall survival in these patients (P = .02). In multivariate analysis, the number of positive axillary lymph nodes and the presence of vascular hot spots in axillary lymph node metastases predicted decreased disease-free survival (P = .0001 and .02, respectively) and overall survival (P = .0001 and .007, respectively). All P values were two-sided. CONCLUSION: This pilot study suggests that assessing neovascularization in axillary lymph node metastases may provide clinically useful information regarding survival in patients with primary breast cancer.


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