© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 23, 1910-1917,
December 6, 2000
© 2000 Oxford University Press
Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study
Affiliations of authors: P. Stattin (Department of Urology and Andrology), A. Bylund (Department of Geriatrics), G. Hallmans (Department of Public Health and Clinical Medicine), Umeå University Hospital, Sweden; S. Rinaldi, C. Biessy, E. Riboli, R. Kaaks, International Agency for Research on Cancer, Lyon, France; H. Déchaud, Central Laboratory for Biochemistry, Hôpital de l'Antiquaille, Lyon; U.-H. Stenman, Department of Clinical Chemistry, Helsinki University Central Hospital, Finland; L. Egevad, Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
Correspondence to: Pär Stattin, M.D., Ph.D., Department of Urology and Andrology, Umeå University Hospital, 901 85 Umeå, Sweden (e-mail: par. stattin{at}urologi.umu.se).
Background: Recent studies have suggested that men with elevated plasma levels of insulin-like growth factor-I (IGF-I) may have an increased risk of prostate cancer. Furthermore, IGF-binding proteins (IGFBPs) and insulin can modulate the activity of IGF-I. In this study, we sought to determine the role of IGF-I as well as IGFBPs-1, -2, and -3 and insulin as possible etiologic factors for prostate cancer. Methods: We conducted a nested case–control study within the Northern Sweden Health and Disease Cohort Study. We measured levels of IGF-I, IGFBP-1, IGFBP-2, IGFBP-3, and insulin in plasma samples from 149 men who had a diagnosis of prostate cancer between 1 month and 10 years after blood collection and among 298 control men. All statistical tests are two-sided. Results: Case subjects had statistically significantly higher mean levels of IGF-I than control subjects (229 ng/mL; 95% confidence interval [CI] = 218–240 ng/mL] versus 214 ng/mL [95% CI = 208–221 ng/mL]; P = .02) and IGFBP-3 (2611 ng/mL [95% CI = 2518–2704 ng/mL] versus 2498 ng/mL [95% CI = 2437–2560 ng/mL]; P = .04). Conditional logistic regression analyses showed increases in prostate cancer risk with rising levels of IGF-I (Pfor trend = .02) and IGFBP-3 (Pfor trend = .03). In case subjects younger than 59 years at the time of blood collection, the risk associated with increased IGF-I was higher (Pfor trend = .01), whereas the risk associated with increased IGFBP-3 was lower (Pfor trend = .44) than the corresponding risks in the full cohort. Prostate cancer risk was not associated with levels of IGFBP-1, IGFBP-2, or insulin. Conclusions: Prostate cancer risk is increased in men with elevated plasma IGF-I. This association was particularly strong in younger men in this study, suggesting that circulating IGF-I may be specifically involved in the early pathogenesis of prostate cancer.
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J. M. Chan, M. J. Stampfer, J. Ma, P. Gann, J. M. Gaziano, M. Pollak, and E. Giovannucci Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 as Predictors of Advanced-Stage Prostate Cancer J Natl Cancer Inst, July 17, 2002; 94(14): 1099 - 1106. [Abstract] [Full Text] [PDF]
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R. E. Schoen, J. Schragin, J. L. Weissfeld, F. L. Thaete, R. W. Evans, C. J. Rosen, and L. H. Kuller Lack of Association between Adipose Tissue Distribution and IGF-1 and IGFBP-3 in Men and Women Cancer Epidemiol. Biomarkers Prev., June 1, 2002; 11(6): 581 - 586. [Abstract] [Full Text] [PDF]
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 R Palmqvist, G Hallmans, S Rinaldi, C Biessy, R Stenling, E Riboli, and R Kaaks Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden Gut, May 1, 2002; 50(5): 642 - 646. [Abstract] [Full Text] [PDF]
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S. F. Shariat, D. J. Lamb, M. W. Kattan, C. Nguyen, J. Kim, J. Beck, T. M. Wheeler, and K. M. Slawin Association of Preoperative Plasma Levels of Insulin-Like Growth Factor I and Insulin-Like Growth Factor Binding Proteins-2 and -3 With Prostate Cancer Invasion, Progression, and Metastasis J. Clin. Oncol., February 1, 2002; 20(3): 833 - 841. [Abstract] [Full Text] [PDF]
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 R. D. Klein and S. M. Fischer Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells Carcinogenesis, January 1, 2002; 23(1): 217 - 221. [Abstract] [Full Text] [PDF]
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L. Chen, M. Stacewicz-Sapuntzakis, C. Duncan, R. Sharifi, L. Ghosh, R. v. Breemen, D. Ashton, and P. E. Bowen Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention J Natl Cancer Inst, December 19, 2001; 93(24): 1872 - 1879. [Abstract] [Full Text] [PDF]
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P. Stattin, U.-H. Stenman, E. Riboli, G. Hallmans, and R. Kaaks Ratios of IGF-I, IGF Binding Protein-3, and Prostate-Specific Antigen in Prostate Cancer Detection J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5745 - 5748. [Abstract] [Full Text] [PDF]
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A. Hoeflich, R. Reisinger, H. Lahm, W. Kiess, W. F. Blum, H. J. Kolb, M. M. Weber, and E. Wolf Insulin-like Growth Factor-binding Protein 2 in Tumorigenesis: Protector or Promoter? Cancer Res., December 1, 2001; 61(24): 8601 - 8610. [Full Text] [PDF]
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R. Kaaks, S. Rinaldi, A. Lukanova, A. Akhmedkhanov, A. Zeleniuch-Jacquotte, and P. Toniolo Correspondence re: Giovannucci et al., A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women. Cancer Epidemiol. Biomark. Prev., 9: 345-349, 2000 Cancer Epidemiol. Biomarkers Prev., October 1, 2001; 10(10): 1103 - 1104. [Full Text] [PDF]
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 W Zumkeller IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth? Mol. Pathol., October 1, 2001; 54(5): 285 - 288. [Abstract] [Full Text] [PDF]
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 S. Gupta, K. Hastak, N. Ahmad, J. S. Lewin, and H. Mukhtar Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols PNAS, August 10, 2001; (2001) 171326098. [Abstract] [Full Text] [PDF]
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T. Nickerson, F. Chang, D. Lorimer, S. P. Smeekens, C. L. Sawyers, and M. Pollak In Vivo Progression of LAPC-9 and LNCaP Prostate Cancer Models to Androgen Independence Is Associated with Increased Expression of Insulin-like Growth Factor I (IGF-I) and IGF-I Receptor (IGF-IR) Cancer Res., August 1, 2001; 61(16): 6276 - 6280. [Abstract] [Full Text] [PDF]
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N. E. Allen and T. J. Key Re: Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study J Natl Cancer Inst, April 18, 2001; 93(8): 649 - 650. [Full Text] [PDF]
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S. Gupta, K. Hastak, N. Ahmad, J. S. Lewin, and H. Mukhtar Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols PNAS, August 28, 2001; 98(18): 10350 - 10355. [Abstract] [Full Text] [PDF]
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