© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 19, 1564-1572,
October 4, 2000
© 2000 Oxford University Press
REVIEW |
Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death
Affiliation of authors: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL.
Correspondence to: Richard I. Morimoto, Ph.D., Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, 2153 N. Campus Dr., Evanston, IL 60208 (e-mail: r-morimoto{at}northwestern.edu).
Exposure of cells to conditions of environmental stress—including heat shock, oxidative stress, heavy metals, or pathologic conditions, such as ischemia and reperfusion, inflammation, tissue damage, infection, and mutant proteins associated with genetic diseases—results in the inducible expression of heat shock proteins that function as molecular chaperones or proteases. Molecular chaperones are a class of proteins that interact with diverse protein substrates to assist in their folding, with a critical role during cell stress to prevent the appearance of folding intermediates that lead to misfolded or otherwise damaged molecules. Consequently, heat shock proteins assist in the recovery from stress either by repairing damaged proteins (protein refolding) or by degrading them, thus restoring protein homeostasis and promoting cell survival. The events of cell stress and cell death are linked, such that molecular chaperones induced in response to stress appear to function at key regulatory points in the control of apoptosis. On the basis of these observations—and on the role of molecular chaperones in the regulation of steroid aporeceptors, kinases, caspases, and other protein remodeling events involved in chromosome replication and changes in cell structure—it is not surprising that the heat shock response and molecular chaperones have been implicated in the control of cell growth. In this review, we address some of the molecular and cellular events initiated by cell stress—the interrelationships between stress signaling, cell death, and oncogenesis—and chaperones as potential targets for cancer diagnosis and treatment.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. R. Logan, H. V. McNeill, S. Cook, X. Lu, D. W. Meek, F. V. Fuller-Pace, J. Lunec, and C. N. Robson Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage Nucleic Acids Res., May 1, 2009; 37(9): 2962 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cervantes-Gomez, R. Nimmanapalli, and V. Gandhi Transcription Inhibition of Heat Shock Proteins: A Strategy for Combination of 17-Allylamino-17-Demethoxygeldanamycin and Actinomycin D Cancer Res., May 1, 2009; 69(9): 3947 - 3954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. KOGA, K. KIHARA, and L. NECKERS Inhibition of Cancer Invasion and Metastasis by Targeting the Molecular Chaperone Heat-shock Protein 90 Anticancer Res, March 1, 2009; 29(3): 797 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Nice, L. Coscoy, and D. H. Raulet Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress J. Exp. Med., February 16, 2009; 206(2): 287 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Korhonen, S. Sjovall, J. Viitanen, E. Ketoja, A. Makarevich, and J. Peippo Viability of bovine embryos following exposure to the green filtered or wider bandwidth light during in vitro embryo production Hum. Reprod., February 1, 2009; 24(2): 308 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wu, J. R. Cypser, A. I. Yashin, and T. E. Johnson The U-Shaped Response of Initial Mortality in Caenorhabditis elegans to Mild Heat Shock: Does It Explain Recent Trends in Human Mortality? J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2008; 63(7): 660 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-Y. Chen, F.-R. Chang, Z.-Y. Huang, J.-H. Chen, Y.-C. Wu, and C.-C. Wu Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins J. Biol. Chem., June 20, 2008; 283(25): 17184 - 17193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Anderson, E. M. Campbell, A. Figueiredo, and T. J. Hope Heat Shock Perturbs TRIM5{alpha} Restriction of Human Immunodeficiency Virus Type 1 J. Virol., March 1, 2008; 82(5): 2575 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dong, M. Ni, J. Li, S. Xiong, W. Ye, J. J. Virrey, C. Mao, R. Ye, M. Wang, L. Pen, et al. Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development Cancer Res., January 15, 2008; 68(2): 498 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, I. S. Ali, and R. W. Currie Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27 Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H74 - H87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. D'Hertog, L. Overbergh, K. Lage, G. B. Ferreira, M. Maris, C. Gysemans, D. Flamez, A. K. Cardozo, G. Van den Bergh, L. Schoofs, et al. Proteomics Analysis of Cytokine-induced Dysfunction and Death in Insulin-producing INS-1E Cells: New Insights into the Pathways Involved Mol. Cell. Proteomics, December 1, 2007; 6(12): 2180 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iwasaki, S. Homma, A. Hishiya, S. J. Dolezal, J. C. Reed, and S. Takayama BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells Cancer Res., November 1, 2007; 67(21): 10252 - 10259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Davenport, H. E. Moore, A. S. Dunlop, S. Y. Sharp, P. Workman, G. J. Morgan, and F. E. Davies Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells Blood, October 1, 2007; 110(7): 2641 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Wang, M.-F. Tsai, T.-H. Dai, T.-M. Hong, W.-K. Chan, J. J.W. Chen, and P.-C. Yang Synergistic Activation of the Tumor Suppressor, HLJ1, by the Transcription Factors YY1 and Activator Protein 1 Cancer Res., May 15, 2007; 67(10): 4816 - 4826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang and X. Shen Heat Shock Protein 27 Protects L929 Cells from Cisplatin-Induced Apoptosis by Enhancing Akt Activation and Abating Suppression of Thioredoxin Reductase Activity Clin. Cancer Res., May 15, 2007; 13(10): 2855 - 2864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mizuno, S. Khurts, T. Seki, Y. Hirota, S. Kaneko, and S. Murakami Human Telomerase Exists in Two Distinct Active Complexes In Vivo J. Biochem., May 1, 2007; 141(5): 641 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Sharp, C. Prodromou, K. Boxall, M. V. Powers, J. L. Holmes, G. Box, T. P. Matthews, K.-M. J. Cheung, A. Kalusa, K. James, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues Mol. Cancer Ther., April 1, 2007; 6(4): 1198 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Yaglom, V. L. Gabai, and M. Y. Sherman High Levels of Heat Shock Protein Hsp72 in Cancer Cells Suppress Default Senescence Pathways Cancer Res., March 1, 2007; 67(5): 2373 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Urushibara, Y. Kageyama, T. Akashi, Y. Otsuka, T. Takizawa, M. Koike, and K. Kihara HSP60 may Predict Good Pathological Response to Neoadjuvant Chemoradiotherapy in Bladder Cancer Jpn. J. Clin. Oncol., January 1, 2007; 37(1): 56 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, I. S. Ali, and R. W. Currie Insulin induces myocardial protection and Hsp70 localization to plasma membranes in rat hearts Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1709 - H1721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. Mimnaugh, W. Xu, M. Vos, X. Yuan, and L. Neckers Endoplasmic Reticulum Vacuolization and Valosin-Containing Protein Relocalization Result from Simultaneous Hsp90 Inhibition by Geldanamycin and Proteasome Inhibition by Velcade Mol. Cancer Res., September 1, 2006; 4(9): 667 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Laubitz, A. Jankowska, A. Sikora, J. Wolinski, R. Zabielski, and E. Grzesiuk Gut myoelectrical activity induces heat shock response in Escherichia coli and Caco-2 cells Exp Physiol, September 1, 2006; 91(5): 867 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Luo, C. Mao, B. Lee, and A. S. Lee GRP78/BiP Is Required for Cell Proliferation and Protecting the Inner Cell Mass from Apoptosis during Early Mouse Embryonic Development Mol. Cell. Biol., August 1, 2006; 26(15): 5688 - 5697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rossi, S. Ciafre, M. Balsamo, P. Pierimarchi, and M. G. Santoro Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Res., August 1, 2006; 66(15): 7678 - 7685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Keppler, A. T. Grady, and M. B. Jarstfer The Biochemical Role of the Heat Shock Protein 90 Chaperone Complex in Establishing Human Telomerase Activity J. Biol. Chem., July 21, 2006; 281(29): 19840 - 19848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. W. Chang, J. Y. H. Chan, J. L. J. Chou, F. C. H. Li, K.-Y. Dai, and S. H. H. Chan Heat shock protein 60 in rostral ventrolateral medulla reduces cardiovascular fatality during endotoxaemia in the rat J. Physiol., July 15, 2006; 574(2): 547 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Milleron and S. B. Bratton Heat Shock Induces Apoptosis Independently of Any Known Initiator Caspase-activating Complex J. Biol. Chem., June 23, 2006; 281(25): 16991 - 17000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-F. Tsai, C.-C. Wang, G.-C. Chang, C.-Y. Chen, H.-Y. Chen, C.-L. Cheng, Y.-P. Yang, C.-Y. Wu, F.-Y. Shih, C.-C. Liu, et al. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. J Natl Cancer Inst, June 21, 2006; 98(12): 825 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-p. Yuan, L.-j. Chen, L.-y. Fan, M.-h. Tang, G.-l. Yang, H.-s. Yang, X.-b. Du, G.-q. Wang, W.-x. Yao, Q.-m. Zhao, et al. Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin. Cancer Res., May 15, 2006; 12(10): 3193 - 3199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Weber Chaperoning Drug Development with PET J. Nucl. Med., May 1, 2006; 47(5): 735 - 737. [Full Text] [PDF]
|
|
|
|
|
|
C. Delettre, V. J. Yuste, R. S. Moubarak, M. Bras, J.-C. Lesbordes-Brion, S. Petres, J. Bellalou, and S. A. Susin AIFsh, a Novel Apoptosis-inducing Factor (AIF) Pro-apoptotic Isoform with Potential Pathological Relevance in Human Cancer J. Biol. Chem., March 10, 2006; 281(10): 6413 - 6427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Malusecka, A. Zborek, S. Krzyzowska-Gruca, and Z. Krawczyk Immunohistochemical Detection of the Inducible Heat Shock Protein Hsp70: A Methodological Study J. Histochem. Cytochem., February 1, 2006; 54(2): 183 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-E. Park, J. Facciponte, X. Chen, I. MacDonald, E. A. Repasky, M. H. Manjili, X.-Y. Wang, and J. R. Subjeck Chaperoning Function of Stress Protein grp170, a Member of the hsp70 Superfamily, Is Responsible for its Immunoadjuvant Activity Cancer Res., January 15, 2006; 66(2): 1161 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Guo, K. Rocha, P. Bali, M. Pranpat, W. Fiskus, S. Boyapalle, S. Kumaraswamy, M. Balasis, B. Greedy, E. S. M. Armitage, et al. Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin Cancer Res., November 15, 2005; 65(22): 10536 - 10544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Banerji, M. Walton, F. Raynaud, R. Grimshaw, L. Kelland, M. Valenti, I. Judson, and P. Workman Pharmacokinetic-Pharmacodynamic Relationships for the Heat Shock Protein 90 Molecular Chaperone Inhibitor 17-Allylamino, 17-Demethoxygeldanamycin in Human Ovarian Cancer Xenograft Models Clin. Cancer Res., October 1, 2005; 11(19): 7023 - 7032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ishitsuka, T. Hideshima, M. Hamasaki, N. Raje, S. Kumar, H. Hideshima, N. Shiraishi, H. Yasui, A. M. Roccaro, P. Richardson, et al. Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis Blood, September 1, 2005; 106(5): 1794 - 1800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bali, M. Pranpat, J. Bradner, M. Balasis, W. Fiskus, F. Guo, K. Rocha, S. Kumaraswamy, S. Boyapalle, P. Atadja, et al. Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90: A NOVEL BASIS FOR ANTILEUKEMIA ACTIVITY OF HISTONE DEACETYLASE INHIBITORS J. Biol. Chem., July 22, 2005; 280(29): 26729 - 26734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Graner and D. D. Bigner Chaperone proteins and brain tumors: Potential targets and possible therapeutics Neuro-oncol, July 1, 2005; 7(3): 260 - 278. [Abstract] [PDF]
|
|
|
|
|
|
N. J. Clemons, K. Buzzard, R. Steel, and R. L. Anderson Hsp72 Inhibits Fas-mediated Apoptosis Upstream of the Mitochondria in Type II Cells J. Biol. Chem., March 11, 2005; 280(10): 9005 - 9012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nakatsu, Y. Yoshida, K. Yamazaki, T. Nakamura, S. Dan, Y. Fukui, and T. Yamori Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays Mol. Cancer Ther., March 1, 2005; 4(3): 399 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gaikwad, A. Poblenz, V. Haridas, C. Zhang, M. Duvic, and J. Gutterman Triterpenoid Electrophiles (Avicins) Suppress Heat Shock Protein-70 and X-Linked Inhibitor of Apoptosis Proteins in Malignant Cells by Activation of Ubiquitin Machinery: Implications for Proapoptotic Activity Clin. Cancer Res., March 1, 2005; 11(5): 1953 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Ferguson, E. S. Anderson, R. B. Harshaw, T. Thate, N. L. Craig, and H. C. M. Nelson Protein Kinase A Regulates Constitutive Expression of Small Heat-Shock Genes in an Msn2/4p-Independent and Hsf1p-Dependent Manner in Saccharomyces cerevisiae Genetics, March 1, 2005; 169(3): 1203 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Xing, D. C. Wilkerson, C. N. Mayhew, E. J. Lubert, H. S. Skaggs, M. L. Goodson, Y. Hong, O.-K. Park-Sarge, and K. D. Sarge Mechanism of hsp70i Gene Bookmarking Science, January 21, 2005; 307(5708): 421 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. WORKMAN Drugging the Cancer Kinome: Progress and Challenges in Developing Personalized Molecular Cancer Therapeutics Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 499 - 515. [Abstract] [PDF]
|
|
|
|
|
|
S. W. Fewell, C. M. Smith, M. A. Lyon, T. P. Dumitrescu, P. Wipf, B. W. Day, and J. L. Brodsky Small Molecule Modulators of Endogenous and Co-chaperone-stimulated Hsp70 ATPase Activity J. Biol. Chem., December 3, 2004; 279(49): 51131 - 51140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Sarmiento, C. C. Anazco, D. M. Campos, G. N. Prado, J. Navarro, and C. B. Gonzalez Novel Down-regulatory Mechanism of the Surface Expression of the Vasopressin V2 Receptor by an Alternative Splice Receptor Variant J. Biol. Chem., November 5, 2004; 279(45): 47017 - 47023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Goswami, W. Wang, J. B. Wyckoff, and J. S. Condeelis Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy Cancer Res., November 1, 2004; 64(21): 7664 - 7667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Plaks, Y. Posen, O. Mazor, A. Brandis, A. Scherz, and Y. Salomon Homologous Adaptation to Oxidative Stress Induced by the Photosensitized Pd-bacteriochlorophyll Derivative (WST11) in Cultured Endothelial Cells J. Biol. Chem., October 29, 2004; 279(44): 45713 - 45720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Novak, F. Paradis, C. Savard, K. Tremblay, and M.-A. Sirard Identification of Porcine Oocyte Proteins That Are Associated with Somatic Cell Nuclei after Co-Incubation Biol Reprod, October 1, 2004; 71(4): 1279 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fujiwara, T. Yamakuni, M. Ueno, M. Ishizuka, T. Shinkawa, T. Isobe, and Y. Ohizumi IC101 Induces Apoptosis by Akt Dephosphorylation via an Inhibition of Heat Shock Protein 90-ATP Binding Activity Accompanied by Preventing the Interaction with Akt in L1210 Cells J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 1288 - 1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bagatell and L. Whitesell Altered Hsp90 function in cancer: A unique therapeutic opportunity Mol. Cancer Ther., August 1, 2004; 3(8): 1021 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Myers and L. M. Mulligan The RET Receptor Is Linked to Stress Response Pathways Cancer Res., July 1, 2004; 64(13): 4453 - 4463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Bae and X. Chen Proteomic Study for the Cellular Responses to Cd2+ in Schizosaccharomyces pombe Through Amino Acid-coded Mass Tagging and Liquid Chromatography Tandem Mass Spectrometry Mol. Cell. Proteomics, June 1, 2004; 3(6): 596 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, W. Wu, Y. Du, S. J. Santos, S. E. Conrad, J. T. Watson, N. Grammatikakis, and K. A. Gallo Hsp90/p50cdc37 Is Required for Mixed-lineage Kinase (MLK) 3 Signaling J. Biol. Chem., May 7, 2004; 279(19): 19457 - 19463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Jones, D. Li, I. M. Wolf, S. A. Wadekar, S. Periyasamy, and E. R. Sanchez Enhancement of Glucocorticoid Receptor-Mediated Gene Expression by Constitutively Active Heat Shock Factor 1 Mol. Endocrinol., March 1, 2004; 18(3): 509 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Hunt, D. J. Dix, G. G. Sharma, R. K. Pandita, A. Gupta, M. Funk, and T. K. Pandita Genomic Instability and Enhanced Radiosensitivity in Hsp70.1- and Hsp70.3-Deficient Mice Mol. Cell. Biol., January 15, 2004; 24(2): 899 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dressel, C. Grzeszik, M. Kreiss, D. Lindemann, T. Herrmann, L. Walter, and E. Gunther Differential Effect of Acute and Permanent Heat Shock Protein 70 Overexpression in Tumor Cells on Lysability by Cytotoxic T Lymphocytes Cancer Res., December 1, 2003; 63(23): 8212 - 8220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Fortugno, E. Beltrami, J. Plescia, J. Fontana, D. Pradhan, P. C. Marchisio, W. C. Sessa, and D. C. Altieri Regulation of survivin function by Hsp90 PNAS, November 25, 2003; 100(24): 13791 - 13796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hamada, S. Kodama, K. Suzuki, and M. Watanabe Gap junctional intercellular communication and cellular response to heat stress Carcinogenesis, November 1, 2003; 24(11): 1723 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Gober, C. C. Smith, K. Ueda, J. A. Toretsky, and L. Aurelian Forced Expression of the H11 Heat Shock Protein Can Be Regulated by DNA Methylation and Trigger Apoptosis in Human Cells J. Biol. Chem., September 26, 2003; 278(39): 37600 - 37609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Frese, M. Schaper, J.-R. Kuster, D. Miescher, M. Jaattela, T. Buehler, and R. A. Schmid Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage J. Thorac. Cardiovasc. Surg., September 1, 2003; 126(3): 748 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Atalay, F. Cardoso, A. Awada, and M. J. Piccart Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer Ann. Onc., September 1, 2003; 14(9): 1346 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-L. Liu, H. Kishi, K. Ohtsuka, and A. Muraguchi Heat shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells Blood, September 1, 2003; 102(5): 1788 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Saydam, F. Steiner, O. Georgiev, and W. Schaffner Heat and Heavy Metal Stress Synergize to Mediate Transcriptional Hyperactivation by Metal-responsive Transcription Factor MTF-1 J. Biol. Chem., August 22, 2003; 278(34): 31879 - 31883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Townsend, R. I. Cutress, A. Sharp, M. Brimmell, and G. Packham BAG-1 Prevents Stress-induced Long-term Growth Inhibition in Breast Cancer Cells via a Chaperone-dependent Pathway Cancer Res., July 15, 2003; 63(14): 4150 - 4157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, M. H. Malone, M. J. Thomenius, F. Zhong, F. Xu, and C. W. Distelhorst Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals J. Biol. Chem., July 11, 2003; 278(29): 27053 - 27058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wegele, M. Haslbeck, J. Reinstein, and J. Buchner Sti1 Is a Novel Activator of the Ssa Proteins J. Biol. Chem., July 3, 2003; 278(28): 25970 - 25976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hondermarck Breast Cancer: When Proteomics Challenges Biological Complexity Mol. Cell. Proteomics, May 1, 2003; 2(5): 281 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Komarova, N. Neznanov, P. G. Komarov, M. V. Chernov, K. Wang, and A. V. Gudkov p53 Inhibitor Pifithrin alpha Can Suppress Heat Shock and Glucocorticoid Signaling Pathways J. Biol. Chem., April 25, 2003; 278(18): 15465 - 15468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Miura, K. Morris, S. Ryan, J. L. Cook, and J. M. Routes Adenovirus E1A, Not Human Papillomavirus E7, Sensitizes Tumor Cells to Lysis by Macrophages Through Nitric Oxide- and TNF-{alpha}-Dependent Mechanisms Despite Up-Regulation of 70-kDa Heat Shock Protein J. Immunol., April 15, 2003; 170(8): 4119 - 4126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Shin, H. Wang, A. M. Yim, F. Le Naour, F. Brichory, J. H. Jang, R. Zhao, E. Puravs, J. Tra, C. W. Michael, et al. Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function J. Biol. Chem., February 21, 2003; 278(9): 7607 - 7616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Gottsch, A. L. Bowers, E. H. Margulies, G. D. Seitzman, S. W. Kim, S. Saha, A. S. Jun, W. J. Stark, and S. H. Liu Serial Analysis of Gene Expression in the Corneal Endothelium of Fuchs' Dystrophy Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 594 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta and A.A. Knowlton Cytosolic Heat Shock Protein 60, Hypoxia, and Apoptosis Circulation, November 19, 2002; 106(21): 2727 - 2733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. M. Kim, Y. Wang, A. Gambotto, Y.-M. Kim, R. Weller, B. S. Zuckerbraun, Y. Hua, S. C. Watkins, and T. R. Billiar Hepatocyte Fas-associating Death Domain Protein/Mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli J. Biol. Chem., October 4, 2002; 277(41): 38855 - 38862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.R. Kirchhoff, S. Gupta, and A.A. Knowlton Cytosolic Heat Shock Protein 60, Apoptosis, and Myocardial Injury Circulation, June 18, 2002; 105(24): 2899 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Mishra, J. Tripp, S. Winkelhaus, B. Tschiersch, K. Theres, L. Nover, and K.-D. Scharf In the complex family of heat stress transcription factors, HsfA1 has a unique role as master regulator of thermotolerance in tomato Genes & Dev., June 15, 2002; 16(12): 1555 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Sullivan and J. M. Pipas T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and Tumorigenesis Microbiol. Mol. Biol. Rev., June 1, 2002; 66(2): 179 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bonvini, T. Gastaldi, B. Falini, and A. Rosolen Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK), a Novel Hsp90-Client Tyrosine Kinase: Down-Regulation of NPM-ALK Expression and Tyrosine Phosphorylation in ALK+ CD30+ Lymphoma Cells by the Hsp90 Antagonist 17-Allylamino,17-demethoxygeldanamycin Cancer Res., March 1, 2002; 62(5): 1559 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hippo, H. Taniguchi, S. Tsutsumi, N. Machida, J.-M. Chong, M. Fukayama, T. Kodama, and H. Aburatani Global Gene Expression Analysis of Gastric Cancer by Oligonucleotide Microarrays Cancer Res., January 1, 2002; 62(1): 233 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Huang, N. F. Mivechi, and D. Moskophidis Insights into Regulation and Function of the Major Stress-Induced hsp70 Molecular Chaperone In Vivo: Analysis of Mice with Targeted Gene Disruption of the hsp70.1 or hsp70.3 Gene Mol. Cell. Biol., December 15, 2001; 21(24): 8575 - 8591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bagatell, O. Khan, G. Paine-Murrieta, C. W. Taylor, S. Akinaga, and L. Whitesell Destabilization of Steroid Receptors by Heat Shock Protein 90-binding Drugs: A Ligand-independent Approach to Hormonal Therapy of Breast Cancer Clin. Cancer Res., July 1, 2001; 7(7): 2076 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chami, D. Gozuacik, D. Lagorce, M. Brini, P. Falson, G. Peaucellier, P. Pinton, H. Lecoeur, M.-L. Gougeon, M. le Maire, et al. SERCA1 Truncated Proteins Unable to Pump Calcium Reduce the Endoplasmic Reticulum Calcium Concentration and Induce Apoptosis J. Cell Biol., June 11, 2001; 153(6): 1301 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Blagosklonny Re: Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death J Natl Cancer Inst, February 7, 2001; 93(3): 239a - 240a. [Full Text]
|
|
|
|
 |
|
 Y Niyaz, M Zeiner, and U Gehring Transcriptional activation by the human Hsp70-associating protein Hap50 J. Cell Sci., January 5, 2001; 114(10): 1839 - 1845. [Abstract] [PDF]
|
|