© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 18, 1472-1489,
September 20, 2000
© 2000 Oxford University Press
REVIEW |
Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression
Affiliations of authors: H. Yu, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport; T. Rohan, Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY.
Correspondence to: Herbert Yu, M.D., Ph.D., Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932 (e-mail: hyu{at}lsumc.edu).
The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF-I receptor, which is also involved in cell transformation induced by tumor virus proteins and oncogene products. Six IGF-binding proteins (IGFBPs) can inhibit or enhance the actions of IGFs. These opposing effects are determined by the structures of the binding proteins. The effects of IGFBPs on IGFs are regulated in part by IGFBP proteases. Laboratory studies have shown that IGFs exert strong mitogenic and antiapoptotic actions on various cancer cells. IGFs also act synergistically with other mitogenic growth factors and steroids and antagonize the effect of antiproliferative molecules on cancer growth. The role of IGFs in cancer is supported by epidemiologic studies, which have found that high levels of circulating IGF-I and low levels of IGFBP-3 are associated with increased risk of several common cancers, including those of the prostate, breast, colorectum, and lung. Evidence further suggests that certain lifestyles, such as one involving a high-energy diet, may increase IGF-I levels, a finding that is supported by animal experiments indicating that IGFs may abolish the inhibitory effect of energy restriction on cancer growth. Further investigation of the role of IGFs in linking high energy intake, increased cell proliferation, suppression of apoptosis, and increased cancer risk may provide new insights into the etiology of cancer and lead to new strategies for cancer prevention.
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S.-C. Chang, R. G. Ziegler, B. Dunn, R. Stolzenberg-Solomon, J. V. Lacey Jr., W.-Y. Huang, A. Schatzkin, D. Reding, R. N. Hoover, P. Hartge, et al. Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 334 - 341. [Abstract] [Full Text] [PDF]
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A. Tavani, L. Giordano, S. Gallus, R. Talamini, S. Franceschi, A. Giacosa, M. Montella, and C. La Vecchia Consumption of sweet foods and breast cancer risk in Italy Ann. Onc., February 1, 2006; 17(2): 341 - 345. [Abstract] [Full Text] [PDF]
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M. L. Irwin, A. McTiernan, L. Bernstein, F. D. Gilliland, R. Baumgartner, K. Baumgartner, and R. Ballard-Barbash Relationship of Obesity and Physical Activity with C-Peptide, Leptin, and Insulin-Like Growth Factors in Breast Cancer Survivors Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2881 - 2888. [Abstract] [Full Text] [PDF]
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T. T. Perls, N. R. Reisman, and S. J. Olshansky Provision or Distribution of Growth Hormone for "Antiaging": Clinical and Legal Issues JAMA, October 26, 2005; 294(16): 2086 - 2090. [Full Text] [PDF]
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T. O. Keku, P. K. Lund, J. Galanko, J. G. Simmons, J. T. Woosley, and R. S. Sandler Insulin Resistance, Apoptosis, and Colorectal Adenoma Risk Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2076 - 2081. [Abstract] [Full Text] [PDF]
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S. J. Cohen, R. B. Cohen, and N. J. Meropol Targeting Signal Transduction Pathways in Colorectal Cancer--More Than Skin Deep J. Clin. Oncol., August 10, 2005; 23(23): 5374 - 5385. [Abstract] [Full Text] [PDF]
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X.-D. Wang Can Smoke-Exposed Ferrets Be Utilized to Unravel the Mechanisms of Action of Lycopene? J. Nutr., August 1, 2005; 135(8): 2053S - 2056S. [Full Text] [PDF]
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C. Sweeney, M. A. Murtaugh, K. B. Baumgartner, T. Byers, A. R. Giuliano, J. S. Herrick, R. Wolff, B. J. Caan, and M. L. Slattery Insulin-Like Growth Factor Pathway Polymorphisms Associated with Body Size in Hispanic and Non-Hispanic White Women Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1802 - 1809. [Abstract] [Full Text] [PDF]
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K. Altundag, O. Altundag, P. Morandi, B. Ozcakar, C. Boruban, M. Tanner, and J. Isola The role of insulin-like growth factor-I receptor in the development of Herceptin resistance Mol. Cancer Ther., July 1, 2005; 4(7): 1136 - 1136. [Full Text] [PDF]
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R. Bianco, T. Troiani, G. Tortora, and F. Ciardiello Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy Endocr. Relat. Cancer, July 1, 2005; 12(Supplement_1): S159 - S171. [Abstract] [Full Text] [PDF]
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H E Jones, J M W Gee, K M Taylor, D Barrow, H D Williams, M Rubini, and R I Nicholson Development of strategies for the use of anti-growth factor treatments Endocr. Relat. Cancer, July 1, 2005; 12(Supplement_1): S173 - S182. [Abstract] [Full Text] [PDF]
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L. M. Morimoto, P. A. Newcomb, E. White, J. Bigler, and J. D. Potter Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1394 - 1401. [Abstract] [Full Text] [PDF]
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A. Malin, C. E. Matthews, X.-O. Shu, H. Cai, Q. Dai, F. Jin, Y.-T. Gao, and W. Zheng Energy Balance and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1496 - 1501. [Abstract] [Full Text] [PDF]
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J. W. Stewart, K. Koehler, W. Jackson, J. Hawley, W. Wang, A. Au, R. Myers, and D. F. Birt Prevention of mouse skin tumor promotion by dietary energy restriction requires an intact adrenal gland and glucocorticoid supplementation restores inhibition Carcinogenesis, June 1, 2005; 26(6): 1077 - 1084. [Abstract] [Full Text] [PDF]
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P. Ioannidis, L. G. Mahaira, S. A. Perez, A. D. Gritzapis, P. A. Sotiropoulou, G. J. Kavalakis, A. I. Antsaklis, C. N. Baxevanis, and M. Papamichail CRD-BP/IMP1 Expression Characterizes Cord Blood CD34+ Stem Cells and Affects c-myc and IGF-II Expression in MCF-7 Cancer Cells J. Biol. Chem., May 20, 2005; 280(20): 20086 - 20093. [Abstract] [Full Text] [PDF]
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Y Min, Y Adachi, H Yamamoto, A Imsumran, Y Arimura, T Endo, Y Hinoda, C-T Lee, S Nadaf, D P Carbone, et al. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts Gut, May 1, 2005; 54(5): 591 - 600. [Abstract] [Full Text] [PDF]
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S. Miyamoto, M. Nakamura, K. Shitara, K. Nakamura, Y. Ohki, G. Ishii, M. Goya, K. Kodama, T. Sangai, H. Maeda, et al. Blockade of Paracrine Supply of Insulin-Like Growth Factors Using Neutralizing Antibodies Suppresses the Liver Metastasis of Human Colorectal Cancers Clin. Cancer Res., May 1, 2005; 11(9): 3494 - 3502. [Abstract] [Full Text] [PDF]
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C. Muller-Tidow, S. Diederichs, E. Bulk, T. Pohle, B. Steffen, J. Schwable, S. Plewka, M. Thomas, R. Metzger, P. M. Schneider, et al. Identification of Metastasis-Associated Receptor Tyrosine Kinases in Non-Small Cell Lung Cancer Cancer Res., March 1, 2005; 65(5): 1778 - 1782. [Abstract] [Full Text] [PDF]
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G. Pandini, R. Mineo, F. Frasca, C. T. Roberts Jr., M. Marcelli, R. Vigneri, and A. Belfiore Androgens Up-regulate the Insulin-like Growth Factor-I Receptor in Prostate Cancer Cells Cancer Res., March 1, 2005; 65(5): 1849 - 1857. [Abstract] [Full Text] [PDF]
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G. S. Warshamana-Greene, J. Litz, E. Buchdunger, C. Garcia-Echeverria, F. Hofmann, and G. W. Krystal The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy Clin. Cancer Res., February 15, 2005; 11(4): 1563 - 1571. [Abstract] [Full Text] [PDF]
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M. L. Irwin, A. McTiernan, R. N. Baumgartner, K. B. Baumgartner, L. Bernstein, F. D. Gilliland, and R. Ballard-Barbash Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors J. Clin. Oncol., February 1, 2005; 23(4): 774 - 782. [Abstract] [Full Text] [PDF]
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J. A Lavigne, D. J Baer, H. H Wimbrow, P. S Albert, E. D Brown, J. T Judd, W. S Campbell, C. A Giffen, J. F Dorgan, T. J Hartman, et al. Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women Am. J. Clinical Nutrition, February 1, 2005; 81(2): 503 - 507. [Abstract] [Full Text] [PDF]
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Y. H. Ibrahim and D. Yee Insulin-Like Growth Factor-I and Breast Cancer Therapy Clin. Cancer Res., January 15, 2005; 11(2): 944s - 950s. [Abstract] [Full Text] [PDF]
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A. Lukanova and R. Kaaks Endogenous Hormones and Ovarian Cancer: Epidemiology and Current Hypotheses Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 98 - 107. [Abstract] [Full Text] [PDF]
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H.-L. Wong, K. DeLellis, N. Probst-Hensch, W.-P. Koh, D. Van Den Berg, H.-P. Lee, M. C. Yu, and S. A. Ingles A New Single Nucleotide Polymorphism in the Insulin-Like Growth Factor I Regulatory Region Associates with Colorectal Cancer Risk in Singapore Chinese Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 144 - 151. [Abstract] [Full Text] [PDF]
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I. S. Rogers, D. Gunnell, P. M. Emmett, L. R. Glynn, D. B. Dunger, J. M. Holly, and and ALSPAC Study Team Cross-Sectional Associations of Diet and Insulin-Like Growth Factor Levels in 7- to 8-Year-Old Children Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 204 - 212. [Abstract] [Full Text] [PDF]
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