© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 10, 833-839,
May 17, 2000
© 2000 Oxford University Press
REPORTS |
Dietary Fat, Fat Subtypes, and Breast Cancer in Postmenopausal Women: a Prospective Cohort Study
Affiliation of authors: E. Velie, A. Schatzkin (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), C. Schairer (Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics), D. Albanes (Cancer Prevention Studies Branch, Division of Clinical Sciences), National Cancer Institute, Bethesda, MD; M. Kulldorff, Division of Biostatistics, Department of Community Medicine and Health Care, University of Connecticut School of Medicine, Farmington; G. Block, Department of Public Health Nutrition, University of California, Berkeley.
Correspondence to: Ellen Velie, Ph.D., National Institutes of Health, 6120 Executive Blvd., MSC 7232, EPS, Rm. 7026, Bethesda, MD 20892 (e-mail: veliee{at}mail.nih.gov).
Background: The intake of total dietary fat and of certain fat subtypes has been shown to be strongly associated with breast cancer in international comparisons and in animal experiments. However, observational epidemiologic studies have generally reported either weak positive or no associations. To extend the prospective epidemiologic evidence on this question, we examined the association between adult dietary intake of fat, fat subtypes, and breast cancer in a large, prospective cohort of postmenopausal women. Methods: Participants were selected from a national breast cancer mammography screening program conducted from 1973 through 1981 at 29 centers throughout the United States. From 1987 through 1989, 40022 postmenopausal women satisfactorily completed a mailed, self-administered questionnaire that included a 60-item National Cancer Institute/Block food-frequency questionnaire. Women were then followed for an average of 5.3 years; 996 women developed breast cancer. Risk was assessed by use of Cox proportional hazard regression, with age as the underlying time metric. All statistical tests were two-sided. Results: Compared with women in the lowest quintile (Q1) of percentage of energy from total fat, the adjusted risk ratio (RR) and 95% confidence interval (CI) for women in the highest quintile (Q5) was 1.07 (95% CI = 0.86–1.32). In analyses stratified by history of benign breast disease (BBD), a positive association was observed among only women with no history of BBD (RR Q5 versus Q1 = 2.20; 95% CI = 1.41–3.42; test for trend, P = .0003). The increased risk in these women appeared to be attributable to unsaturated fat intake and oleic acid in particular. Conclusions: In this study, there was no overall association between fat intake during adulthood and breast cancer risk; however, among women with no history of BBD, there appeared to be a positive association between total and unsaturated fat intake and breast cancer risk.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Sieri, V. Krogh, P. Ferrari, F. Berrino, V. Pala, A. C. Thiebaut, A. Tjonneland, A. Olsen, K. Overvad, M. U. Jakobsen, et al. Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1304 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mazhar and J. Waxman Dietary fat and breast cancer QJM, July 1, 2006; 99(7): 469 - 473. [Full Text] [PDF]
|
|
|
|
 |
|
 S.-C. Chang, R. G. Ziegler, B. Dunn, R. Stolzenberg-Solomon, J. V. Lacey Jr., W.-Y. Huang, A. Schatzkin, D. Reding, R. N. Hoover, P. Hartge, et al. Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 334 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M Velie, C. Schairer, A. Flood, J.-P. He, R. Khattree, and A. Schatzkin Empirically derived dietary patterns and risk of postmenopausal breast cancer in a large prospective cohort study Am. J. Clinical Nutrition, December 1, 2005; 82(6): 1308 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Boyd Insulin and Cancer Integr Cancer Ther, December 1, 2003; 2(4): 315 - 329. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Cho, D. Spiegelman, D. J. Hunter, W. Y. Chen, M. J. Stampfer, G. A. Colditz, and W. C. Willett Premenopausal Fat Intake and Risk of Breast Cancer J Natl Cancer Inst, July 16, 2003; 95(14): 1079 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Byrne, H. Rockett, and M. D. Holmes Dietary Fat, Fat Subtypes, and Breast Cancer Risk: Lack of an Association among Postmenopausal Women with No History of Benign Breast Disease Cancer Epidemiol. Biomarkers Prev., March 1, 2002; 11(3): 261 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sano and M. Sasako Green Tea and Gastric Cancer N. Engl. J. Med., March 1, 2001; 344(9): 675 - 676. [Full Text] [PDF]
|
|