© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 7, 620-625,
April 7, 1999
© 1999 Oxford University Press
REPORTS |
Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3
Affiliations of authors: J. Ma, Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston MA; M. N. Pollak, Y. Tao, Departments of Medicine and Oncology, Cancer Prevention Research Unit, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Canada; E. Giovannucci, Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School and Department of Nutrition, Harvard School of Public Health, Boston; J. M. Chan, Department of Epidemiology, Harvard School of Public Health; C. H. Hennekens, Department of Epidemiology, Harvard School of Public Health and Division of Preventive Medicine, Departments of Medicine and Ambulatory Care and Prevention, Brigham and Women's Hospital and Harvard Medical School; M. J. Stampfer, Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School and Departments of Nutrition and Epidemiology, Harvard School of Public Health.
Correspondence to: Jing Ma, M.D., Ph.D., Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave., Boston, MA 02115 (e-mail: Jing.Ma{at}channing.harvard.edu).
BACKGROUND: Insulin-like growth factor-I (IGF-I) is a potent mitogen for normal and neoplastic cells, whereas IGF-binding protein-3 (IGFBP-3) inhibits cell growth in many experimental systems. Acromegalics, who have abnormally high levels of growth hormone and IGF-I, have higher rates of colorectal cancer. We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study. METHODS: Plasma samples were collected at baseline from 14 916 men without diagnosed cancer. IGF-I, IGF-II, and IGFBP-3 were assayed among 193 men later diagnosed with colorectal cancer during 14 years of follow-up and among 318 age- and smoking-matched control subjects. All P values are two-sided. RESULTS: IGFBP-3 levels correlated with IGF-I levels (r = .64) and with IGF-II levels (r = .90). After controlling for IGFBP-3, age, smoking, body mass index (weight in kg/[height in m]2), and alcohol intake, men in the highest quintile for IGF-I had an increased risk of colorectal cancer compared with men in the lowest quintile (relative risk [RR] = 2.51; 95% confidence interval [CI] = 1.15-5.46; P for trend = .02). After controlling for IGF-I and other covariates, men with higher IGFBP-3 had a lower risk (RR = 0.28; 95% CI = 0.12-0.66; P for trend = .005, comparing extreme quintiles). The associations were consistent during the first and the second 7-year follow-up intervals and among younger and older men. IGF-II was not associated with risk. CONCLUSIONS: Our findings suggest that circulating IGF-I and IGFBP-3 are related to future risk of colorectal cancer.
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F. Canzian, J. D. McKay, R. J. Cleveland, L. Dossus, C. Biessy, C. Boillot, S. Rinaldi, M. Llewellyn, V. Chajes, F. Clavel-Chapelon, et al. Genetic Variation in the Growth Hormone Synthesis Pathway in Relation to Circulating Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and Breast Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition Study Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2316 - 2325. [Abstract] [Full Text] [PDF]
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T. O. Keku, P. K. Lund, J. Galanko, J. G. Simmons, J. T. Woosley, and R. S. Sandler Insulin Resistance, Apoptosis, and Colorectal Adenoma Risk Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2076 - 2081. [Abstract] [Full Text] [PDF]
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Y. Wang, J. Hailey, D. Williams, Y. Wang, P. Lipari, M. Malkowski, X. Wang, L. Xie, G. Li, D. Saha, et al. Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody Mol. Cancer Ther., August 1, 2005; 4(8): 1214 - 1221. [Abstract] [Full Text] [PDF]
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J. I. Fenton, N. G. Hord, J. A. Lavigne, S. N. Perkins, and S. D. Hursting Leptin, Insulin-Like Growth Factor-1, and Insulin-Like Growth Factor-2 Are Mitogens in ApcMin/+ but not Apc+/+ Colonic Epithelial Cell Lines Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1646 - 1652. [Abstract] [Full Text] [PDF]
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J. Gibney, G. Johannsson, K.-C. Leung, and K. K. Y. Ho Comparison of the Metabolic Effects of Raloxifene and Oral Estrogen in Postmenopausal and Growth Hormone-Deficient Women J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3897 - 3903. [Abstract] [Full Text] [PDF]
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L. M. Morimoto, P. A. Newcomb, E. White, J. Bigler, and J. D. Potter Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1394 - 1401. [Abstract] [Full Text] [PDF]
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J. A. Meyerhardt, J. A. Sloan, D. J. Sargent, R. M. Goldberg, M. Pollak, R. F. Morton, R. K. Ramanathan, S. K. Williamson, B. P. Findlay, and C. S. Fuchs Associations between Plasma Insulin-Like Growth Factor Proteins and C-Peptide and Quality of Life in Patients with Metastatic Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1402 - 1410. [Abstract] [Full Text] [PDF]
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S. Otake, H. Takeda, Y. Suzuki, T. Fukui, S. Watanabe, K. Ishihama, T. Saito, H. Togashi, T. Nakamura, Y. Matsuzawa, et al. Association of Visceral Fat Accumulation and Plasma Adiponectin with Colorectal Adenoma: Evidence for Participation of Insulin Resistance Clin. Cancer Res., May 15, 2005; 11(10): 3642 - 3646. [Abstract] [Full Text] [PDF]
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C. Diorio, M. Pollak, C. Byrne, B. Masse, N. Hebert-Croteau, M. Yaffe, G. Cote, S. Berube, C. Morin, and J. Brisson Insulin-Like Growth Factor-I, IGF-Binding Protein-3, and Mammographic Breast Density Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1065 - 1073. [Abstract] [Full Text] [PDF]
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L. M. Morimoto, P. A. Newcomb, E. White, J. Bigler, and J. D. Potter Insulin-like Growth Factor Polymorphisms and Colorectal Cancer Risk Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1204 - 1211. [Abstract] [Full Text] [PDF]
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L. Le Marchand, L. N. Kolonel, B. E. Henderson, and L. R. Wilkens Association of an Exon 1 Polymorphism in the IGFBP3 Gene with Circulating IGFBP-3 Levels and Colorectal Cancer Risk: The Multiethnic Cohort Study Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1319 - 1321. [Abstract] [Full Text] [PDF]
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Y Min, Y Adachi, H Yamamoto, A Imsumran, Y Arimura, T Endo, Y Hinoda, C-T Lee, S Nadaf, D P Carbone, et al. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts Gut, May 1, 2005; 54(5): 591 - 600. [Abstract] [Full Text] [PDF]
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E. K. Wei, J. Ma, M. N. Pollak, N. Rifai, C. S. Fuchs, S. E. Hankinson, and E. Giovannucci A Prospective Study of C-Peptide, Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-1, and the Risk of Colorectal Cancer in Women Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 850 - 855. [Abstract] [Full Text] [PDF]
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M. Ishikawa, J. Kitayama, S. Kazama, T. Hiramatsu, K. Hatano, and H. Nagawa Plasma Adiponectin and Gastric Cancer Clin. Cancer Res., January 15, 2005; 11(2): 466 - 472. [Abstract] [Full Text] [PDF]
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Y. H. Ibrahim and D. Yee Insulin-Like Growth Factor-I and Breast Cancer Therapy Clin. Cancer Res., January 15, 2005; 11(2): 944s - 950s. [Abstract] [Full Text] [PDF]
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S. Rinaldi, R. Kaaks, A. Zeleniuch-Jacquotte, A. A. Arslan, R. E. Shore, K. L. Koenig, L. Dossus, E. Riboli, P. Stattin, A. Lukanova, et al. Insulin-Like Growth Factor-I, IGF Binding Protein-3, and Breast Cancer in Young Women: A Comparison of Risk Estimates Using Different Peptide Assays Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 48 - 52. [Abstract] [Full Text] [PDF]
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P. J. Limburg, K. E. Anderson, T. W. Johnson, D. R. Jacobs Jr., D. Lazovich, C.-P. Hong, K. K. Nicodemus, and A. R. Folsom Diabetes Mellitus and Subsite-Specific Colorectal Cancer Risks in the Iowa Women's Health Study Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 133 - 137. [Abstract] [Full Text] [PDF]
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H.-L. Wong, K. DeLellis, N. Probst-Hensch, W.-P. Koh, D. Van Den Berg, H.-P. Lee, M. C. Yu, and S. A. Ingles A New Single Nucleotide Polymorphism in the Insulin-Like Growth Factor I Regulatory Region Associates with Colorectal Cancer Risk in Singapore Chinese Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 144 - 151. [Abstract] [Full Text] [PDF]
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D. W. Voskuil, A. Vrieling, L. J. van't Veer, E. Kampman, and M. A. Rookus The Insulin-like Growth Factor System in Cancer Prevention: Potential of Dietary Intervention Strategies Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 195 - 203. [Abstract] [Full Text] [PDF]
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I. Baik, W. J. DeVito, K. Ballen, P. S. Becker, W. Okulicz, Q. Liu, E. Delpapa, P. Lagiou, S. Sturgeon, D. Trichopoulos, et al. Association of Fetal Hormone Levels with Stem Cell Potential: Evidence for Early Life Roots of Human Cancer Cancer Res., January 1, 2005; 65(1): 358 - 363. [Abstract] [Full Text] [PDF]
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M. Terzolo, G. Reimondo, M. Gasperi, R. Cozzi, R. Pivonello, G. Vitale, A. Scillitani, R. Attanasio, E. Cecconi, F. Daffara, et al. Colonoscopic Screening and Follow-Up in Patients with Acromegaly: A Multicenter Study in Italy J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 84 - 90. [Abstract] [Full Text] [PDF]
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S. M. Gapstur, P. Kopp, B. C-H. Chiu, P. H. Gann, L. A. Colangelo, and K. Liu Longitudinal Associations of Age, Anthropometric and Lifestyle Factors with Serum Total Insulin-Like Growth Factor-I and IGF Binding Protein-3 Levels in Black and White Men: the CARDIA Male Hormone Study Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2208 - 2216. [Abstract] [Full Text] [PDF]
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A J van der Lely Justified and unjustified use of growth hormone Postgrad. Med. J., October 1, 2004; 80(948): 577 - 580. [Abstract] [Full Text] [PDF]
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M. Pold, K. Krysan, A. Pold, M. Dohadwala, N. Heuze-Vourc'h, J. T. Mao, K. L. Riedl, S. Sharma, and S. M. Dubinett Cyclooxygenase-2 Modulates the Insulin-Like Growth Factor Axis in Non-Small-Cell Lung Cancer Cancer Res., September 15, 2004; 64(18): 6549 - 6555. [Abstract] [Full Text] [PDF]
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K. DeLellis, S. Rinaldi, R. J. Kaaks, L. N. Kolonel, B. Henderson, and L. Le Marchand Dietary and Lifestyle Correlates of Plasma Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3): The Multiethnic Cohort Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1444 - 1451. [Abstract] [Full Text] [PDF]
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S. D. Hursting, J. A. Lavigne, D. Berrigan, L. A. Donehower, B. J. Davis, J. M. Phang, J. C. Barrett, and S. N. Perkins Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target J. Nutr., September 1, 2004; 134(9): 2482S - 2486S. [Abstract] [Full Text] [PDF]
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C. Hoppe, T. Rovenna Udam, L. Lauritzen, C. Molgaard, A. Juul, and K. Fleischer Michaelsen Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children Am. J. Clinical Nutrition, August 1, 2004; 80(2): 447 - 452. [Abstract] [Full Text] [PDF]
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P. Stattin, S. Rinaldi, C. Biessy, U.-H. Stenman, G. Hallmans, and R. Kaaks High Levels of Circulating Insulin-Like Growth Factor-I Increase Prostate Cancer Risk: A Prospective Study in a Population-Based Nonscreened Cohort J. Clin. Oncol., August 1, 2004; 22(15): 3104 - 3112. [Abstract] [Full Text] [PDF]
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