© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 7, 614-619,
April 7, 1999
© 1999 Oxford University Press
REPORTS |
Early Age at Smoking Initiation and Tobacco Carcinogen DNA Damage in the Lung
Affiliations of authors: J. K. Wiencke, A.Varkonyi, Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco; S. W. Thurston, Department of Biostatistics, Harvard School of Public Health, Boston, MA; K. T. Kelsey, Department of Cancer Cell Biology and Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston; J. C. Wain, Thoracic Surgery Unit, Department of Surgery, Massachusetts General Hospital, Boston; E. J. Mark, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston; D. C. Christiani, Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, and Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.
Correspondence to: John K. Wiencke, Ph.D., Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, 500 Parnassus Ave., San Francisco, CA 94143-0560 (e-mail: wiencke{at}itsa.ucsf.edu).
BACKGROUND: DNA adducts formed as a consequence of exposure to tobacco smoke may be involved in carcinogenesis, and their presence may indicate a high risk of lung cancer. To determine whether DNA adducts can be used as a "dosimeter" for cancer risk, we measured the adduct levels in nontumorous lung tissue and blood mononuclear cells from patients with lung cancer, and we collected data from the patients on their history of smoking. METHODS: We used the 32P-postlabeling assay to measure aromatic hydrophobic DNA adducts in nontumorous lung tissue from 143 patients and in blood mononuclear cells from 54 of these patients. From the smoking histories, we identified exposure variables associated with increased DNA adduct levels by use of multivariate analyses with negative binomial regression models. RESULTS/CONCLUSIONS: We found statistically significant interactions for variables of current and former smoking and for other smoking variables (e.g., pack-years [number of packs smoked per day x years of smoking] or years smoked), indicating that the impact of smoking variables on DNA adduct levels may be different in current and former smokers. Consequently, our analyses indicate that models for current and former smokers should be considered separately. In current smokers, recent smoking intensity (cigarettes smoked per day) was the most important variable. In former smokers, age at smoking initiation was inversely associated with DNA adduct levels. A highly statistically significant correlation (r = .77 [Spearman's correlation]; two sided P<.001) was observed between DNA adduct levels in blood mononuclear cells and lung tissue. IMPLICATIONS: Our results in former smokers suggest that smoking during adolescence may produce physiologic changes that lead to increased DNA adduct persistence or that young smokers may be markedly susceptible to DNA adduct formation and have higher adduct burdens after they quit smoking than those who started smoking later in life.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. P. Massion, Y. Zou, H. Chen, A. Jiang, P. Coulson, C. I. Amos, X. Wu, I. Wistuba, Q. Wei, Y. Shyr, et al. Smoking-related Genomic Signatures in Non-Small Cell Lung Cancer Am. J. Respir. Crit. Care Med., December 1, 2008; 178(11): 1164 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dubey and C. A. Powell Update in Lung Cancer 2007 Am. J. Respir. Crit. Care Med., May 1, 2008; 177(9): 941 - 946. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis and F. Perera Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 547 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Robinson, K. M. Emmons, E. T. Moolchan, and J. S. Ostroff Developing Smoking Cessation Programs for Chronically Ill Teens: Lessons Learned from Research with Healthy Adolescent Smokers J. Pediatr. Psychol., March 1, 2008; 33(2): 133 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Gyorffy, L. Anna, K. Kovacs, P. Rudnai, and B. Schoket Correlation between biomarkers of human exposure to genotoxins with focus on carcinogen-DNA adducts Mutagenesis, January 1, 2008; 23(1): 1 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis and F. Perera Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1954 - 1965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Castano-Vinyals, G. Talaska, N. Rothman, J. Alguacil, M. Garcia-Closas, M. Dosemeci, K. P. Cantor, N. Malats, F. X. Real, D. Silverman, et al. Bulky DNA Adduct Formation and Risk of Bladder Cancer Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2155 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qiu, S. Leng, Z. Wang, Y. Dai, Y. Zheng, and Z. Wang Path Analysis of Biomarkers of Exposure and Early Biological Effects among Coke-Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1193 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. McCLEAN, J. K. WIENCKE, K. T. KELSEY, A. VARKONYI, L. NGO, E. A. EISEN, and R. F. HERRICK DNA Adducts among Asphalt Paving Workers Ann. Hyg., January 1, 2007; 51(1): 27 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M M Freemer, T E King Jr, and L A Criswell Association of smoking with dsDNA autoantibody production in systemic lupus erythematosus Ann Rheum Dis, May 1, 2006; 65(5): 581 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Thurston, G. Liu, D. P. Miller, and D. C. Christiani Modeling Lung Cancer Risk in Case-Control Studies Using a New Dose Metric of Smoking Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2296 - 2302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kheifets, M. Repacholi, R. Saunders, and E. van Deventer The Sensitivity of Children to Electromagnetic Fields Pediatrics, August 1, 2005; 116(2): e303 - e313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Kofahi and L. G. Haddad Perceptions of Lung Cancer and Smoking Among College Students in Jordan J Transcult Nurs, July 1, 2005; 16(3): 245 - 254. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Kelley, E. M. Glaser, J. E. Herndon II, F. Becker, R. Bhagat, Y.-J. Zhang, R. M. Santella, S. G. Carmella, S. S. Hecht, L. Gallot, et al. Safety and Efficacy of Weekly Oral Oltipraz in Chronic Smokers Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 892 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Peluso, M. Neri, G. Margarino, C. Mereu, A. Munnia, M. Ceppi, M. Buratti, R. Felletti, F. Stea, R. Quaglia, et al. Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms Carcinogenesis, December 1, 2004; 25(12): 2459 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Espandiari, H. P. Glauert, H.-J. Lehmler, E. Y. Lee, C. Srinivasan, and L. W. Robertson Initiating Activity of 4-Chlorobiphenyl Metabolites in the Resistant Hepatocyte Model Toxicol. Sci., May 1, 2004; 79(1): 41 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Vineis, G Matullo, and M Manuguerra An evolutionary paradigm for carcinogenesis? J Epidemiol Community Health, February 1, 2003; 57(2): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Moro-Sibilot, M. Jeanmart, S. Lantuejoul, F. Arbib, M. H. Laverriere, E. Brambilla, and C. Brambilla Cigarette Smoking, Preinvasive Bronchial Lesions, and Autofluorescence Bronchoscopy Chest, December 1, 2002; 122(6): 1902 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Phillips Smoking-related DNA and protein adducts in human tissues Carcinogenesis, December 1, 2002; 23(12): 1979 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Shields Tobacco Smoking, Harm Reduction, and Biomarkers J Natl Cancer Inst, October 2, 2002; 94(19): 1435 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. P. Perera, L. A. Mooney, M. Stampfer, D. H. Phillips, D. A. Bell, A. Rundle, S. Cho, W.-Y. Tsai, J. Ma, A. Blackwood, et al. Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study Carcinogenesis, October 1, 2002; 23(10): 1641 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.K. Field and J.H. Youngson The Liverpool Lung Project: a molecular epidemiological study of early lung cancer detection Eur. Respir. J., August 1, 2002; 20(2): 464 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Li, J. Eckard, R. Shah, C. Malluck, and K. Frenkel Interleukin-1{alpha} Up-Regulation in Vivo by a Potent Carcinogen 7,12-Dimethylbenz(a)anthracene (DMBA) and Control of DMBA-induced Inflammatory Responses Cancer Res., January 1, 2002; 62(2): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Stellman, T. Takezaki, L. Wang, Y. Chen, M. L. Citron, M. V. Djordjevic, S. Harlap, J. E. Muscat, A. I. Neugut, E. L. Wynder, et al. Smoking and Lung Cancer Risk in American and Japanese Men: An International Case-Control Study Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1193 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tang, D. H. Phillips, M. Stampfer, L. A. Mooney, Y. Hsu, S. Cho, W.-Y. Tsai, J. Ma, K. J. Cole, M. N. She, et al. Association between Carcinogen-DNA Adducts in White Blood Cells and Lung Cancer Risk in the Physicians Health Study Cancer Res., September 1, 2001; 61(18): 6708 - 6712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Merzenich, A. Hartwig, W. Ahrens, D. Beyersmann, R. Schlepegrell, M. Scholze, J. Timm, and K.-H. Jöckel Biomonitoring on Carcinogenic Metals and Oxidative DNA Damage in a Cross-Sectional Study Cancer Epidemiol. Biomarkers Prev., May 1, 2001; 10(5): 515 - 522. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. A. Aloise-Young, K. M. Hennigan, and C. W. Leong Possible Selves and Negative Health Behaviors During Early Adolescence The Journal of Early Adolescence, May 1, 2001; 21(2): 158 - 181. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Peluso, M. Ceppi, A. Munnia, R. Puntoni, and S. Parodi Analysis of 13 32P-DNA Postlabeling Studies on Occupational Cohorts Exposed to Air Pollution Am. J. Epidemiol., March 15, 2001; 153(6): 546 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hirao, H. H. Nelson, T. D. S. Ashok, J. C. Wain, E. J. Mark, D. C. Christiani, J. K. Wiencke, and K. T. Kelsey Tobacco Smoke-induced DNA Damage and an Early Age of Smoking Initiation Induce Chromosome Loss at 3p21 in Lung Cancer Cancer Res., January 1, 2001; 61(2): 612 - 615. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. T. Ashburn, S. K. Wilson, and B. I. Eisenstein Human Tissue Research in the Genomic Era of Medicine: Balancing Individual and Societal Interests Arch Intern Med, December 11, 2000; 160(22): 3377 - 3384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Jacobson, M. D. Begg, L. W. Wang, Q. Wang, M. Agarwal, E. Norkus, V. N. Singh, T.-L. Young, D. Yang, and R. M. Santella Effects of a 6-Month Vitamin Intervention on DNA Damage in Heavy Smokers Cancer Epidemiol. Biomarkers Prev., December 1, 2000; 9(12): 1303 - 1311. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Stein, C. K. Haddock, K. K. O'Byrne, N. Hymowitz, and J. Schwab The Pediatrician's Role in Reducing Tobacco Exposure in Children Pediatrics, November 1, 2000; 106(5): 66e - 66. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. J. Heimann A School-Based Intervention Program to Prevent Adolescent Smoking The Journal of School Nursing, October 1, 2000; 16(4): 22 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Trock Out of the Mouths of Babes: Oral Premalignant Lesions and Use of Alternative Tobacco Products Cancer Epidemiol. Biomarkers Prev., July 1, 2000; 9(7): 637 - 638. [Full Text]
|
|
|
|
|
|
F. P. Perera Molecular Epidemiology: On the Path to Prevention? J Natl Cancer Inst, April 19, 2000; 92(8): 602 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. HILL Why we should tackle adult smoking first Tob. Control, September 1, 1999; 8(3): 333 - 335. [Full Text]
|
|
|
|
|
|
J. H. Glaser Re: Early Age at Smoking Initiation and Tobacco Carcinogen DNA Damage in the Lung J Natl Cancer Inst, August 18, 1999; 91(16): 1423 - 1423. [Full Text] [PDF]
|
|
|
|
|
|
J. K. Wiencke RESPONSE: Re: Early Age at Smoking Initiation and Tobacco Carcinogen DNA Damage in the Lung J Natl Cancer Inst, August 18, 1999; 91(16): 1423a - 1423a. [Full Text]
|
|
|
|
|
|
M. R. Spitz, M. de Andrade, and J. Di Giovanni Molecular Dosimeters of Smoking Damage in the Lung J Natl Cancer Inst, April 7, 1999; 91(7): 578 - 579. [Full Text] [PDF]
|
|