Skip Navigation

JNCI Journal of the National Cancer Institute 1999 91(4):359-367; doi:10.1093/jnci/91.4.359
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Mäkitie, T.
Right arrow Articles by Kivelä, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mäkitie, T.
Right arrow Articles by Kivelä, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 91, No. 4, 359-367, February 17, 1999
© 1999 Oxford University Press

ARTICLES

Microvascular Loops and Networks as Prognostic Indicators in Choroidal and Ciliary Body Melanomas

Teemu Mäkitie, Paula Summanen, Ahti Tarkkanen, Tero Kivelä

Affiliation of authors: Department of Ophthalmology,Helsinki University Central Hospital, Finland.

Correspondence to: Tero Kivelä, M.D., Vitreoretinal and Oncology Service, Department of Ophthalmology, Helsinki University Central Hospital, Haartmaninkatu 4 C, P.O. Box 220, FIN-00029 HYKS, Finland (e-mail: tero.kivela{at}helsinki.fi).

BACKGROUND: Malignant melanoma of the ciliary body and choroid of the eye is a tumor that disseminates frequently, and 50% of the diagnosed patients die within 10 years. We investigated the hypothesis that, by histopathologic analysis of the arrangement of microvessels (i.e., small blood vessels) in loops and networks, we might be able to differentiate better those patients with a favorable prognosis from those with a poor prognosis. METHODS: We conducted a population-based, retrospective cohort study of melanoma-specific and all-cause mortality for 167 consecutive patients who had an eye surgically removed because of malignant choroidal or ciliary body melanoma during the period from 1972 through 1981. Microvascular loops and networks were evaluated independently by two pathologists who were unaware of patient outcome. RESULTS: Microvascular patterns could be assessed in 134 (80%) of 167 melanoma specimens. The 10-year probability of melanoma-specific survival was worse if microvascular loops (0.45 versus 0.83; two-sided P<.0001) and networks (0.41 versus 0.72, two-sided P<.0001) were present. In multivariate Cox regression analysis of melanoma-specific survival, the hazard ratios were 1.66 (95% confidence interval [CI] = 1.19-2.30) for the presence of loops and networks as a combined three-category variable, 2.36 (95% CI = 1.37-4.05) for the presence of epithelioid cells, 1.11 (95% CI = 1.03-1.19) for the largest basal tumor diameter (evaluated as a continuous variable), and 2.14 (95% CI = 1.25-3.67) for ciliary body involvement. CONCLUSIONS: Patients with malignant uveal melanoma who have a favorable prognosis can be distinguished from those with a poor prognosis by histopathologic analysis of microvascular patterns in uveal melanoma tumor specimens.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 IOVSHome page
J. W. Harbour
Eye Cancer: Unique Insights into Oncogenesis The Cogan Lecture
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1737 - 1745.
[Full Text] [PDF]

Home page
 IOVSHome page
S. S. Kadkol, A. Y. Lin, V. Barak, I. Kalickman, L. Leach, K. Valyi-Nagy, D. Majumdar, S. Setty, A. J. Maniotis, R. Folberg, et al.
Osteopontin expression and serum levels in metastatic uveal melanoma: a pilot study.
Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 802 - 806.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. D. Braun and A. Abbas
Orthotopic Human Choroidal Melanoma Xenografts in Nude Rats with Aggressive and Nonaggressive PAS Staining Patterns
Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 7 - 16.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. Toivonen, T. Makitie, E. Kujala, and T. Kivela
Microcirculation and Tumor-Infiltrating Macrophages in Choroidal and Ciliary Body Melanoma and Corresponding Metastases
Invest. Ophthalmol. Vis. Sci., January 1, 2004; 45(1): 1 - 6.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
E. Kujala, T. Makitie, and T. Kivela
Very Long-Term Prognosis of Patients with Malignant Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., November 1, 2003; 44(11): 4651 - 4659.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Kivela and P. M. Grambsch
Evaluation of Sampling Strategies for Modeling Survival of Uveal Malignant Melanoma
Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3288 - 3293.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
X. Chen, Z. Ai, M. Rasmussen, P. Bajcsy, L. Auvil, M. Welge, L. Leach, S. Vangveeravong, A. J. Maniotis, and R. Folberg
Three-Dimensional Reconstruction of Extravascular Matrix Patterns and Blood Vessels in Human Uveal Melanoma Tissue: Techniques and Preliminary Findings
Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 2834 - 2840.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R.'a T. Al-Jamal, T. Makitie, and T. Kivela
Nucleolar Diameter and Microvascular Factors as Independent Predictors of Mortality from Malignant Melanoma of the Choroid and Ciliary Body
Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2381 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. G. M. Scholes, B. E. Damato, J. Nunn, P. Hiscott, I. Grierson, and J. K. Field
Monosomy 3 in Uveal Melanoma: Correlation with Clinical and Histologic Predictors of Survival
Invest. Ophthalmol. Vis. Sci., March 1, 2003; 44(3): 1008 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
T. M. Walker, P. R. van Ginkel, R. L. Gee, H. Ahmadi, L. Subramanian, B. R. Ksander, L. F. Meisner, D. M. Albert, and A. S. Polans
Expression of Angiogenic Factors Cyr61 and Tissue Factor in Uveal Melanoma
Arch Ophthalmol, December 1, 2002; 120(12): 1719 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y.-J. Lee, N. Nagai, C.-H. Siar, K. Nakano, H. Nagatsuka, H. Tsujigiwa, C.-H. Roan, and M. Gunduz
Angioarchitecture of Primary Oral Malignant Melanomas
J. Histochem. Cytochem., November 1, 2002; 50(11): 1555 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
S R Boyd, D S W Tan, L de Souza, M H Neale, N E Myatt, R A Alexander, M Robb, J L Hungerford, and I A Cree
Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growth
Br. J. Ophthalmol., April 1, 2002; 86(4): 440 - 447.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. Toivonen and T. Kivela
Unusual Tumors Involving the Head and Neck Region: Case 2. Malignant Uveal Melanoma in Ocular Melanocytosis
J. Clin. Oncol., November 1, 2001; 19(21): 4174 - 4177.
[Full Text] [PDF]

Home page
 IOVSHome page
T. Makitie, O. Carpen, A. Vaheri, and T. Kivela
Ezrin as a Prognostic Indicator and Its Relationship to Tumor Characteristics in Uveal Malignant Melanoma
Invest. Ophthalmol. Vis. Sci., October 1, 2001; 42(11): 2442 - 2449.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. G. M. Scholes, T. Liloglou, P. Maloney, S. Hagan, J. Nunn, P. Hiscott, B. E. Damato, I. Grierson, and J. K. Field
Loss of Heterozygosity on Chromosomes 3, 9, 13, and 17, Including the Retinoblastoma Locus, in Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., October 1, 2001; 42(11): 2472 - 2477.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Kivela, S. Eskelin, T. Makitie, and P. Summanen
Exudative Retinal Detachment from Malignant Uveal Melanoma: Predictors and Prognostic Significance
Invest. Ophthalmol. Vis. Sci., August 1, 2001; 42(9): 2085 - 2093.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
T. Mäkitie, P. Summanen, A. Tarkkanen, and T. Kivelä
Tumor-Infiltrating Macrophages (CD68+ Cells) and Prognosis in Malignant Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1414 - 1421.
[Abstract] [Full Text]

Home page
 IOVSHome page
R. Clarijs, L. Schalkwijk, D. J. Ruiter, and R. M. W. de Waal
Lack of Lymphangiogenesis Despite Coexpression of VEGF-C and Its Receptor Flt-4 in Uveal Melanoma
Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1422 - 1428.
[Abstract] [Full Text]

Home page
 Arch OphthalmolHome page
The Collaborative Ocular Melanoma Study Group
Assessment of Metastatic Disease Status at Death in 435 Patients With Large Choroidal Melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS Report No. 15
Arch Ophthalmol, May 1, 2001; 119(5): 670 - 676.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
A. G. M. Scholes, S. Hagan, P. Hiscott, B. E. Damato, and I. Grierson
Overexpression of Epidermal Growth Factor Receptor Restricted to Macrophages in Uveal Melanoma
Arch Ophthalmol, March 1, 2001; 119(3): 373 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. A. Warso, A. J. Maniotis, X. Chen, D. Majumdar, M. K. Patel, A. Shilkaitis, T. K. Das Gupta, and R. Folberg
Prognostic Significance of Periodic Acid-Schiff-positive Patterns in Primary Cutaneous Melanoma
Clin. Cancer Res., March 1, 2001; 7(3): 473 - 477.
[Abstract] [Full Text]

Home page
 Arch OphthalmolHome page
T. Makitie and T. Kivela
Cardiac Metastasis From Uveal Melanoma
Arch Ophthalmol, January 1, 2001; 119(1): 139 - 140.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Folberg, M. J. C. Hendrix, and A. J. Maniotis
Vasculogenic Mimicry and Tumor Angiogenesis
Am. J. Pathol., February 1, 2000; 156(2): 361 - 381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. M. McDonald, L. Munn, and R. K. Jain
Vasculogenic Mimicry: How Convincing, How Novel, and How Significant?
Am. J. Pathol., February 1, 2000; 156(2): 383 - 388.
[Full Text] [PDF]

Home page
 IOVSHome page
T. Makitie, P. Summanen, A. Tarkkanen, and T. Kivela
Microvascular Density in Predicting Survival of Patients with Choroidal and Ciliary Body Melanoma
Invest. Ophthalmol. Vis. Sci., October 1, 1999; 40(11): 2471 - 2480.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. J. Bissell
Tumor Plasticity Allows Vasculogenic Mimicry, a Novel Form of Angiogenic Switch : A Rose by Any Other Name?
Am. J. Pathol., September 1, 1999; 155(3): 675 - 679.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. J. Maniotis, R. Folberg, A. Hess, E. A. Seftor, L. M.G. Gardner, J. Pe'er, J. M. Trent, P. S. Meltzer, and M. J. C. Hendrix
Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry
Am. J. Pathol., September 1, 1999; 155(3): 739 - 752.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.