© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 2, 151-156,
January 20, 1999
© 1999 Oxford University Press
Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis
Affiliations of authors: H. Yu, Section of Cancer Prevention and Control, Feist-Weiller Cancer Center, Louisiana State University Medical Center, Shreveport; M. R. Spitz, J. Gu, X. Wu (Department of Epidemiology), W. K. Hong (Department of Thoracic/Head and Neck Medical Oncology), The University of Texas M. D. Anderson Cancer Center, Houston; J. Mistry, Diagnostic Systems Laboratory, Inc. Webster, TX.
Correspondence to: Xifeng Wu, M.D. Ph.D., Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.
BACKGROUND: Insulin-like growth factors (IGFs), in particular IGF-I and IGF-II, strongly stimulate the proliferation of a variety of cancer cells, including those from lung cancer. To examine the possible causal role of IGFs in lung cancer development, we compared plasma levels of IGF-I, IGF-II, and an IGF-binding protein (IGFBP-3) in patients with newly diagnosed lung cancer and in control subjects. METHODS: From an ongoing hospital-based, case-control study, we selected 204 consecutive patients with histologically confirmed, primary lung cancer and 218 control subjects who were matched to the case patients by age, sex, race, and smoking status. IGF-I, IGF-II, and IGFBP-3 plasma levels were measured by enzyme-linked immunosorbent assay and then divided into quartiles, based on their distribution in the control subjects. Associations between the IGF variables and lung cancer risk were estimated by use of odds ratios (ORs). Reported P values are two-sided. RESULTS: IGF and IGFBP-3 levels were positively correlated (all r>.27; all P<.001). High plasma levels of IGF-I were associated with an increased risk of lung cancer (OR = 2.06; 95% confidence interval [CI] = 1.19-3.56; P = .01), and this association was dose dependent in both univariate and multivariate analyses. Plasma IGFBP-3 showed no association with lung cancer risk unless adjusted for IGF-I level; when both of these variables were analyzed together, high plasma levels of IGFBP-3 were associated with reduced risk of lung cancer (OR = 0.48; 95% CI = 0.25-0.92; P = .03). IGF-II was not associated with lung cancer risk. CONCLUSIONS: Plasma levels of IGF-I are higher and plasma levels of IGFBP-3 are lower in patients with lung cancer than in control subjects. If these findings can be confirmed in prospective studies, measuring levels of IGF-I and IGFBP-3 in blood may prove useful in assessing lung cancer risk.
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C. Deal, J. Ma, F. Wilkin, J. Paquette, F. Rozen, B. Ge, T. Hudson, M. Stampfer, and M. Pollak Novel Promoter Polymorphism in Insulin-Like Growth Factor-Binding Protein-3: Correlation with Serum Levels and Interaction with Known Regulators J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1274 - 1280. [Abstract] [Full Text]
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E. M. Erfurth, B. Bülow, Z. Mikoczy, and L. Hagmar Incidence of a Second Tumor in Hypopituitary Patients Operated for Pituitary Tumors J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 659 - 662. [Abstract] [Full Text]
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J. Khosravi, A. Diamandi, J. Mistry, and A. Scorilas Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3 in Benign Prostatic Hyperplasia and Prostate Cancer J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 694 - 699. [Abstract] [Full Text]
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H. Yu and T. Rohan Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression J Natl Cancer Inst, September 20, 2000; 92(18): 1472 - 1489. [Abstract] [Full Text] [PDF]
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X. Wu, H. Yu, C. I. Amos, W. K. Hong, and M. R. Spitz Joint Effect of Insulin-Like Growth Factors and Mutagen Sensitivity in Lung Cancer Risk J Natl Cancer Inst, May 3, 2000; 92(9): 737 - 743. [Abstract] [Full Text] [PDF]
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E. Giovannucci, M. N. Pollak, E. A. Platz, W. C. Willett, M. J. Stampfer, N. Majeed, G. A. Colditz, F. E. Speizer, and S. E. Hankinson A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women Cancer Epidemiol. Biomarkers Prev., April 1, 2000; 9(4): 345 - 349. [Abstract] [Full Text]
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E. A. Platz, M. N. Pollak, E. B. Rimm, N. Majeed, Y. Tao, W. C. Willett, and E. Giovannucci Racial Variation in Insulin-Like Growth Factor-1 and Binding Protein-3 Concentrations in Middle-Aged Men Cancer Epidemiol. Biomarkers Prev., December 1, 1999; 8(12): 1107 - 1110. [Abstract] [Full Text]
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H. Yu Re: Cyclin D1 Proteolysis: a Retinoid Chemoprevention Signal in Normal, Immortalized, and Transformed Human Bronchial Epithelial Cells J Natl Cancer Inst, October 6, 1999; 91(19): 1685 - 1685. [Full Text] [PDF]
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K. D. Burroughs, S. E. Dunn, J. C. Barrett, and J. A. Taylor Insulin-Like Growth Factor-I: a Key Regulator of Human Cancer Risk? J Natl Cancer Inst, April 7, 1999; 91(7): 579 - 581. [Full Text] [PDF]
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