Skip Navigation

JNCI Journal of the National Cancer Institute 1999 91(11):950-953; doi:10.1093/jnci/91.11.950
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Martínez, M. E.
Right arrow Articles by Alberts, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martínez, M. E.
Right arrow Articles by Alberts, D. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 91, No. 11, 950-953, June 2, 1999
© 1999 Oxford University Press

REPORTS

Physical Activity, Body Mass Index, and Prostaglandin E2 Levels in Rectal Mucosa

María Elena Martínez, David Heddens, David L. Earnest, Cheryl L. Bogert, Denise Roe, Janine Einspahr, James R. Marshall, David S. Alberts

Affiliations of authors: M. E. Martínez, D. Roe, J. R. Marshall, Arizona Cancer Center and Arizona Prevention Center, University of Arizona, Tucson; D. Heddens, C. L. Bogert, J. Einspahr, Arizona Cancer Center, University of Arizona; D. L. Earnest, D. S. Alberts, Arizona Cancer Center and Department of Medicine, University of Arizona.

Correspondence to:María Elena Martínez, Ph.D., Arizona Cancer Center, University of Arizona, 1515 N. Campbell Ave., Tucson, AZ 85724 (e-mail: emartinez{at}azcc.arizona.edu).

BACKGROUND: Evidence suggests a relationship between prostaglandin levels in colonic mucosa and risk of colon cancer. Physical inactivity and a higher body mass index (BMI; weight in kilograms divided by [height in meters]2) have been consistently shown to increase risk of this cancer. We investigated whether higher levels of leisure-time physical activity or a lower BMI was associated with lower concentrations of prostaglandin E2 (PGE2) in rectal mucosa. METHODS: This study was conducted in 41 men and 22 women, 42-78 years of age, with a history of polyps, who participated in a randomized clinical trial testing the effects of piroxicam on rectal mucosal PGE2 levels. An [125I]PGE2 radioimmunoassay kit was used to determine PGE2 levels in samples of extracted rectal mucosa collected before randomization. Leisure-time physical activity was assessed through a self-administered questionnaire collected at baseline. The reported time spent at each activity per week was multiplied by its typical energy expenditure, expressed in metabolic equivalents (METs), to yield a MET-hours per week score. A repeated measures model was used to assess the effect of BMI and physical activity as predictors of PGE2 concentration. All statistical tests were two-sided. RESULTS: After adjustment for age, a higher BMI was associated with higher PGE2 levels (P = .001). A higher level of leisure-time physical activity was inversely associated with PGE2 concentration (P<.03). An increase in BMI from 24.2 to 28.8 kg/m2 was associated with a 27% increase in PGE2. An increase in activity level from 5.2 to 27.7 MET-hours per week was associated with a 28% decrease in PGE2. CONCLUSIONS: Physical activity and obesity may alter the risk of colon cancer through their effects on PGE2 synthesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
B. C. Wertheim, M. E. Martinez, E. L. Ashbeck, D. J. Roe, E. T. Jacobs, D. S. Alberts, and P. A. Thompson
Physical Activity as a Determinant of Fecal Bile Acid Levels
Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1591 - 1598.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. E. Abrahamson, I. B. King, C. M. Ulrich, R. E. Rudolph, M. L. Irwin, Y. Yasui, C. Surawicz, J. W. Lampe, P. D. Lampe, A. Morgan, et al.
No Effect of Exercise on Colon Mucosal Prostaglandin Concentrations: A 12-Month Randomized Controlled Trial
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2351 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
K. F. Adams, M. F. Leitzmann, D. Albanes, V. Kipnis, T. Mouw, A. Hollenbeck, and A. Schatzkin
Body Mass and Colorectal Cancer Risk in the NIH-AARP Cohort
Am. J. Epidemiol., July 1, 2007; 166(1): 36 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
K. G. Hauret, R. M. Bostick, C. E. Matthews, J. R. Hussey, M. F. Fina, K. R. Geisinger, and W. M. Roufail
Physical Activity and Reduced Risk of Incident Sporadic Colorectal Adenomas: Observational Support for Mechanisms Involving Energy Balance and Inflammation Modulation
Am. J. Epidemiol., May 15, 2004; 159(10): 983 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. A. Colangelo, S. M. Gapstur, P. H. Gann, A. R. Dyer, and K. Liu
Colorectal Cancer Mortality and Factors Related to the Insulin Resistance Syndrome
Cancer Epidemiol. Biomarkers Prev., April 1, 2002; 11(4): 385 - 391.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. ATTOUB, V. NOE, L. PIROLA, E. BRUYNEEL, E. CHASTRE, M. MAREEL, M. P. WYMANN, and C. GESPACH
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways
FASEB J, November 1, 2000; 14(14): 2329 - 2338.
[Abstract] [Full Text]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H-H. S. Chow, D. L. Earnest, D. Clark, N. Mason-Liddil, C. B. Kramer, J. G. Einspahr, J. M. Guillen-Rodriguez, D. J. Roe, W. Malone, J. A. Crowell, et al.
Effect of Subacute Ibuprofen Dosing on Rectal Mucosal Prostaglandin E2 Levels in Healthy Subjects with a History of Resected Polyps
Cancer Epidemiol. Biomarkers Prev., April 1, 2000; 9(4): 351 - 356.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.