© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 11, 943-949,
June 2, 1999
© 1999 Oxford University Press
Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer
Affiliations of authors: J. Peto, Section of Epidemiology, Institute of Cancer Research, Surrey, U.K., and London School of Hygiene and Tropical Medicine, London, U.K.; N. Collins, R. Barfoot, S. Seal, W. Warren, N. Rahman, M. R. Stratton, Section of Cancer Genetics, Institute of Cancer Research; D. F. Easton, CRC Genetic Epidemiology Group, Strangeways Laboratories, Cambridge, U.K.; C. Evans, J. Deacon, Section of Epidemiology, Institute of Cancer Research.
Correspondence to: Michael R. Stratton, M.B.B.S., Ph.D., Haddow Laboratories, Institute of Cancer Research, 15 Cotswold Rd., Sutton, Surrey, SM2 5NG, U.K. (e-mail: mikes{at}icr.ac.uk).
BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with many cases of early-onset breast cancer. However, in an outbred population, the prevalence of BRCA1 and BRCA2 mutations in patients with breast cancer who were unselected for a family history of this disease has not been determined. METHODS: Mutations in the BRCA1 and BRCA2 genes were detected in blood samples from two population-based series of young patients with breast cancer from Britain. RESULTS: Mutations were detected in 15 (5.9%) of 254 women diagnosed with breast cancer before age 36 years (nine [3.5%] in BRCA1 and six [2.4%] in BRCA2) and in 15 (4.1%) of 363 women diagnosed from ages 36 through 45 years (seven [1.9%] in BRCA1 and eight [2.2%] in BRCA2). Eleven percent (six of 55) of patients with a first-degree relative who developed ovarian cancer or breast cancer by age 60 years were mutation carriers, compared with 45% (five of 11) of patients with two or more affected first- or second-degree relatives. The standardized incidence ratio for breast cancer in mothers and sisters was 365 (five observed and 1.37 expected) for 30 mutation carriers and 199 (64 observed and 32.13 expected) for 587 noncarriers. If we assume recent penetrance estimates, the respective proportions of BRCA1 and BRCA2 mutation carriers are 3.1% and 3.0%, respectively, of patients with breast cancer who are younger than age 50 years, 0.49% and 0.84% of patients with breast cancer who are age 50 years or older, and 0.11% and 0.12% of women in the general population. CONCLUSIONS: Mutations in the BRCA1 and BRCA2 genes make approximately equal contributions to early-onset breast cancer in Britain and account for a small proportion of the familial risk of breast cancer.
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|
|
|
|
|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
D G R Evans, D M Eccles, N Rahman, K Young, M Bulman, E Amir, A Shenton, A Howell, and F Lalloo A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO J. Med. Genet., June 1, 2004; 41(6): 474 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Choi, M. H. Lee, A. E. Bale, D. Carter, and B. G. Haffty Incidence of BRCA1 and BRCA2 Mutations in Young Korean Breast Cancer Patients J. Clin. Oncol., May 1, 2004; 22(9): 1638 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Suter, R. M. Ray, Y. W. Hu, M. G. Lin, P. Porter, D. L. Gao, R. E. Zaucha, L. M. Iwasaki, L. P. Sabacan, M. C. Langlois, et al. BRCA1 and BRCA2 Mutations in Women from Shanghai China Cancer Epidemiol. Biomarkers Prev., February 1, 2004; 13(2): 181 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Hampel, K Sweet, J A Westman, K Offit, and C Eng Referral for cancer genetics consultation: a review and compilation of risk assessment criteria J. Med. Genet., February 1, 2004; 41(2): 81 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
R. A. Oldenburg, K. Kroeze-Jansema, J. Kraan, H. Morreau, J. G. M. Klijn, N. Hoogerbrugge, M. J. L. Ligtenberg, C. J. van Asperen, H. F. A. Vasen, C. Meijers, et al. The CHEK2*1100delC Variant Acts as a Breast Cancer Risk Modifier in Non-BRCA1/BRCA2 Multiple-Case Families Cancer Res., December 1, 2003; 63(23): 8153 - 8157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stevens Racial Meanings and Scientific Methods: Changing Policies for NIH-Sponsored Publications Reporting Human Variation Journal of Health Politics Policy and Law, December 1, 2003; 28(6): 1033 - 1088. [Abstract] [PDF]
|
|
|
|
|
|
N. Moullan, D. G. Cox, S. Angele, P. Romestaing, J.-P. Gerard, and J. Hall Polymorphisms in the DNA Repair Gene XRCC1, Breast Cancer Risk, and Response to Radiotherapy Cancer Epidemiol. Biomarkers Prev., November 1, 2003; 12(11): 1168 - 1174. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. de Jong, I. M. Nolte, E. G. E. de Vries, M. Schaapveld, J. H. Kleibeuker, E. Oosterom, J. C. Oosterwijk, A. H. van der Hout, G. van der Steege, M. Bruinenberg, et al. The HLA class III subregion is responsible for an increased breast cancer risk Hum. Mol. Genet., September 15, 2003; 12(18): 2311 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 K. Hemminki, H. Zhang, and K. Czene Time Trends and Familial Risks in Squamous Cell Carcinoma of the Skin Arch Dermatol, July 1, 2003; 139(7): 885 - 889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C E Jacobi, M A Jonker, N J D Nagelkerke, J C van Houwelingen, and G H de Bock Prevalence of family histories of breast cancer in the general population and the incidence of related seeking of health care J. Med. Genet., July 1, 2003; 40(7): e83 - 83. [Full Text] [PDF]
|
|
|
|
|
|
H. Meijers-Heijboer, C. T.M. Brekelmans, M. Menke-Pluymers, C. Seynaeve, A. Baalbergen, C. Burger, E. Crepin, A. W.M. van den Ouweland, B. van Geel, and J. G.M. Klijn Use of Genetic Testing and Prophylactic Mastectomy and Oophorectomy in Women With Breast or Ovarian Cancer From Families With a BRCA1 or BRCA2 Mutation J. Clin. Oncol., May 1, 2003; 21(9): 1675 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Dite, M. A. Jenkins, M. C. Southey, J. S. Hocking, G. G. Giles, M. R. E. McCredie, D. J. Venter, and J. L. Hopper Familial Risks, Early-Onset Breast Cancer, and BRCA1 and BRCA2 Germline Mutations J Natl Cancer Inst, March 19, 2003; 95(6): 448 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Domchek, A. Eisen, K. Calzone, J. Stopfer, A. Blackwood, and B. L. Weber Application of Breast Cancer Risk Prediction Models in Clinical Practice J. Clin. Oncol., February 15, 2003; 21(4): 593 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hearle, B. E. Damato, J. Humphreys, J. Wixey, H. Green, J. Stone, D. F. Easton, and R. S. Houlston Contribution of Germline Mutations in BRCA2, P16INK4A, P14ARF and P15 to Uveal Melanoma Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 458 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. F. Boyd, G. S. Dite, J. Stone, A. Gunasekara, D. R. English, M. R.E. McCredie, G. G. Giles, D. Tritchler, A. Chiarelli, M. J. Yaffe, et al. Heritability of Mammographic Density, a Risk Factor for Breast Cancer N. Engl. J. Med., September 19, 2002; 347(12): 886 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Begg On the Use of Familial Aggregation in Population-Based Case Probands for Calculating Penetrance J Natl Cancer Inst, August 21, 2002; 94(16): 1221 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|