© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 1, 66-72,
January 6, 1999
© 1999 Oxford University Press
REPORTS |
Effects of Vinorelbine on Quality of Life and Survival of Elderly Patients With Advanced Non-Small-Cell Lung Cancer
Correspondence to: Cesare Gridelli, M.D., Divisione di Oncologia Medica B, Istituto Nazionale per lo Studio e la Cura dei Tumori, via M. Semmola, 80131 Naples, Italy (e-mail: cgridelli{at}sirio-oncology.it).
BACKGROUND: Vinorelbine, a semisynthetic vinca alkaloid, represents a well-tolerated treatment for elderly patients with advanced non-small-cell lung cancer (NSCLC). We explored the quality of life (QoL) of such patients in a multicenter randomized trial that compared vinorelbine treatment with supportive care alone. METHODS: Eligible patients were 70 years of age or older, had stage IV or IIIB NSCLC that was ineligible for radiotherapy, and had a performance status of 0-2 (a status of fully active to a status of capable of all self-care but unable to work). Vinorelbine was given intravenously on days 1 and 8 of a 21-day treatment cycle, for a total of six cycles. QoL was evaluated with European Organization for Research and Treatment of Cancer questionnaires QLQ-C30 and QLQ-LC13, and the QoL data were analyzed by fitting a linear mixed model for each QoL scale. Survival curves were plotted and were compared with the Mantel-Haenszel test. Relative hazards of death and 95% confidence intervals (CIs) were estimated by the Cox model. RESULTS: Investigators, blinded to the results, stopped the trial early because of a low enrollment rate. (From April 1996 to November 1997, 191 of the 350 targeted patients were randomly assigned.) Data from 161 patients have been analyzed. Vinorelbine-treated patients scored better than control patients on QoL functioning scales, and they reported fewer lung cancer-related symptoms but reported worse toxicity-related symptoms. There was a statistically significant (two-sided P = .03) survival advantage for patients receiving vinorelbine; median survival increased from 21 to 28 weeks in the vinorelbine-treated group. The relative hazard of death for vinorelbine-treated patients was 0.65 (95% CI = 0.45-0.93). CONCLUSION: Vinorelbine improves survival of elderly patients with advanced NSCLC and possibly improves overall QoL.
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
|
 |
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C. C. Earle Outcomes Research in Lung Cancer J Natl Cancer Inst Monographs, October 1, 2004; 2004(33): 56 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M. Dediu Should We Discard Vinorelbine Plus Cisplatin From the First-Line Therapy of Advanced Non-Small-Cell Lung Cancer? J. Clin. Oncol., April 1, 2004; 22(7): 1345 - 1347. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A. Hurria and M. G. Kris Management of Lung Cancer in Older Adults CA Cancer J Clin, November 1, 2003; 53(6): 325 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
M Cullen Lung cancer * 4: Chemotherapy for non-small cell lung cancer: the end of the beginning Thorax, April 1, 2003; 58(4): 352 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 S. G. Spiro and J. C. Porter Lung Cancer--Where Are We Today?: Current Advances in Staging and Nonsurgical Treatment Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1166 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
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|
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|
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|
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|
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A. Inoue and N. Saijo Recent Advances in the Chemotherapy of Non-small Cell Lung Cancer Jpn. J. Clin. Oncol., July 1, 2001; 31(7): 299 - 304. [Abstract] [Full Text] [PDF]
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I. E. Smith, M. E.R. O'Brien, D. C. Talbot, M. C. Nicolson, J. L. Mansi, T. F. Hickish, A. Norton, and S. Ashley Duration of Chemotherapy in Advanced Non-Small-Cell Lung Cancer: A Randomized Trial of Three Versus Six Courses of Mitomycin, Vinblastine, and Cisplatin J. Clin. Oncol., March 1, 2001; 19(5): 1336 - 1343. [Abstract] [Full Text] [PDF]
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Y. Ohe, S. Niho, R. Kakinuma, K. Kubota, T. Matsumoto, H. Ohmatsu, K. Goto, H. Kunitoh, N. Saijo, and Y. Nishiwaki Phase I Studies of Cisplatin and Docetaxel Administered by Three Consecutive Weekly Infusions for Advanced Non-small Cell Lung Cancer in Elderly and Non-elderly Patients Jpn. J. Clin. Oncol., March 1, 2001; 31(3): 100 - 106. [Abstract] [Full Text] [PDF]
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M. A. Socinski, A. B. Sandler, L. L. Miller, P. K. Locker, C. K. Hanover, G. L. Elfring, V. K. Israel, N. Pirotta, and R. B. Natale Phase I Trial of the Combination of Irinotecan, Paclitaxel, and Carboplatin in Patients With Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., February 15, 2001; 19(4): 1078 - 1087. [Abstract] [Full Text] [PDF]
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 M. M Kirollos, D. Munday, M. Michael, J. Zalcberg, and D I Jeffrey Chemotherapy for advanced colorectal cancer BMJ, January 27, 2001; 322(7280): 232a - 232. [Full Text]
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M. Ranson, N. Davidson, M. Nicolson, S. Falk, J. Carmichael, P. Lopez, H. Anderson, N. Gustafson, A. Jeynes, G. Gallant, et al. Randomized Trial of Paclitaxel Plus Supportive Care Versus Supportive Care for Patients With Advanced Non-Small-Cell Lung Cancer J Natl Cancer Inst, July 5, 2000; 92(13): 1074 - 1080. [Abstract] [Full Text] [PDF]
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G. Frasci, V. Lorusso, N. Panza, P. Comella, G. Nicolella, A. Bianco, G. De Cataldis, A. Iannelli, D. Bilancia, M. Belli, et al. Gemcitabine Plus Vinorelbine Versus Vinorelbine Alone in Elderly Patients With Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., July 1, 2000; 18(13): 2529 - 2536. [Abstract] [Full Text] [PDF]
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A. PRICE Patient accrual into chemotherapy trials in non-small cell lung cancer Thorax, June 1, 2000; 55(6): 447 - 448. [Full Text]
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C. C. Earle, L. N. Venditti, P. J. Neumann, R. D. Gelber, M. C. Weinstein, A. L. Potosky, and J. C. Weeks Who Gets Chemotherapy for Metastatic Lung Cancer? Chest, May 1, 2000; 117(5): 1239 - 1246. [Abstract] [Full Text] [PDF]
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L. F. Hutchins, J. M. Unger, J. J. Crowley, C. A. Coltman, and K. S. Albain Underrepresentation of Patients 65 Years of Age or Older in Cancer-Treatment Trials N. Engl. J. Med., December 30, 1999; 341(27): 2061 - 2067. [Abstract] [Full Text] [PDF]
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V.R. Archer, L.J. Billingham, and M.H. Cullen Palliative Chemotherapy: No Longer a Contradiction in Terms Oncologist, December 1, 1999; 4(6): 470 - 477. [Abstract] [Full Text]
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A. Sandler and D. S. Ettinger Gemcitabine: Single-Agent and Combination Therapy in Non-Small Cell Lung Cancer Oncologist, June 1, 1999; 4(3): 241 - 251. [Abstract] [Full Text]
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M. J. Edelman Commentary on "Gemcitabine: Single-Agent and Combination Therapy in Non-Small Cell Lung Cancer" : The Oncologist 1999;4:241-251 Oncologist, June 1, 1999; 4(3): 252 - 255. [Full Text]
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