© 1998 by Oxford University Press
Journal Of The National Cancer Institute, Vol 90, 1873-1880, Copyright © 1998 by Oxford University Press
P Autier, JF Dore, MS Cattaruzza, F Renard, H Luther, F Gentiloni-Silverj, E Zantedeschi, M Mezzetti, I Monjaud, M Andry, JF Osborn and AR Grivegnee
BACKGROUND: Previous epidemiologic studies have suggested that sunscreen
use is associated with an increased risk of melanoma skin cancer. Because
high nevi (mole) count in adults is a strong predictor of melanoma, we
conducted a study examining the number of nevi in 6- to 7-year-old European
children, according to their sunscreen use. METHODS: Whole-body and
site-specific counts of nevi 2 mm or larger were performed in 631 children
in their first year of primary school in four European cities.
Independently, parents were interviewed regarding sun exposure, sunscreen
use, and physical sun protection of their child. RESULTS: After adjustment
for sun exposure and host characteristics (e.g., skin phototype, eye
color), the relative risk for high nevus count on the trunk was 1.68 (95%
confidence interval [CI] = 1.09-2.59) for the highest level of sunscreen
use and 0.59 (95% CI = 0.36-0.97) for the highest level of wearing of
clothes while in the sun. The sun protection factor had no effect on nevus
counts despite a high median value of 17.4. Sunburn number was not
associated with nevus count. The highest risk associated with sunscreen use
was found among children who had never experienced sunburn. CONCLUSIONS: In
white, European children, sunscreen use appears to be associated with
development of nevi, probably because it allows longer sun exposures.
Wearing clothes may be an effective way to prevent proliferation of nevi.
Since a high nevus count is a strong predictor of melanoma, sunscreen use
may be involved in melanoma occurrence because it may encourage
recreational sun exposure.
REVIEWS
Sunscreen use, wearing clothes, and number of nevi in 6- to 7-year-old European children. European Organization for Research and Treatment of Cancer Melanoma Cooperative Group
European Institute of Oncology, Milan, Italy. pautier@ieo.it
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. J. Pettijohn, N. L. Asdigian, J. Aalborg, J. G. Morelli, S. T. Mokrohisky, R. P. Dellavalle, and L. A. Crane Vacations to Waterside Locations Result in Nevus Development in Colorado Children Cancer Epidemiol. Biomarkers Prev., February 1, 2009; 18(2): 454 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Crane, S. T. Mokrohisky, R. P. Dellavalle, N. L. Asdigian, J. Aalborg, T. E. Byers, C. Zeng, A. E. Baron, J. M. Burch, and J. G. Morelli Melanocytic Nevus Development in Colorado Children Born in 1998: A Longitudinal Study Arch Dermatol, February 1, 2009; 145(2): 148 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Oliveria, J. M. Satagopan, A. C. Geller, S. W. Dusza, M. A. Weinstock, M. Berwick, M. Bishop, M. K. Heneghan, and A. C. Halpern Study of Nevi in Children (SONIC): Baseline Findings and Predictors of Nevus Count Am. J. Epidemiol., January 1, 2009; 169(1): 41 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Berwick Counterpoint: Sunscreen Use Is a Safe and Effective Approach to Skin Cancer Prevention Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1923 - 1924. [Full Text] [PDF]
|
|
|
|
|
|
A. T. Dodd, J. Morelli, S. T. Mokrohisky, N. Asdigian, T. E. Byers, and L. A. Crane Melanocytic Nevi and Sun Exposure in a Cohort of Colorado Children: Anatomic Distribution and Site-Specific Sunburn Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2136 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Rodvall, C.-F. Wahlgren, H. Ullen, and K. Wiklund Common Melanocytic Nevi in 7-Year-Old Schoolchildren Residing at Different Latitudes in Sweden Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 122 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M Cassell, D. T Halperin, J. D Shelton, and D. Stanton Risk compensation: the Achilles' heel of innovations in HIV prevention? BMJ, March 11, 2006; 332(7541): 605 - 607. [Full Text] [PDF]
|
|
|
|
 |
|
 S A Oliveria, M Saraiya, A C Geller, M K Heneghan, and C Jorgensen Sun exposure and risk of melanoma Arch. Dis. Child., February 1, 2006; 91(2): 131 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Neely Basal Cell and Squamous Cell Carcinoma in Persons Younger Than 40 Years JAMA, January 18, 2006; 295(3): 278 - 278. [Full Text] [PDF]
|
|
|
|
|
|
D. R. English, E. Milne, and J. A. Simpson Sun Protection and the Development of Melanocytic Nevi in Children Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2873 - 2876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Valiukeviciene, I. Miseviciene, and H. Gollnick The Prevalence of Common Acquired Melanocytic Nevi and the Relationship With Skin Type Characteristics and Sun Exposure Among Children in Lithuania Arch Dermatol, May 1, 2005; 141(5): 579 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bauer, P. Buttner, T. S. Wiecker, H. Luther, and C. Garbe Effect of Sunscreen and Clothing on the Number of Melanocytic Nevi in 1,812 German Children Attending Day Care Am. J. Epidemiol., April 1, 2005; 161(7): 620 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Harrison, P. G. Buettner, and R. MacLennan The North Queensland "Sun-Safe Clothing" Study: Design and Baseline Results of a Randomized Trial to Determine the Effectiveness of Sun-Protective Clothing in Preventing Melanocytic Nevi Am. J. Epidemiol., March 15, 2005; 161(6): 536 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Autier, M. Boniol, G. Severi, R. Pedeux, A.-R. Grivegnee, J.-F. Dore, and European Organisation for Research and Treatment o Sex Differences in Numbers of Nevi on Body Sites of Young European Children: Implications for the Etiology of Cutaneous Melanoma Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2003 - 2005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Synnerstad, L. Nilsson, M. Fredrikson, and I. Rosdahl Fewer Melanocytic Nevi Found in Children With Active Atopic Dermatitis Than in Children Without Dermatitis Arch Dermatol, December 1, 2004; 140(12): 1471 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Balk, K. G. O'Connor, and M. Saraiya Counseling Parents and Children on Sun Protection: A National Survey of Pediatricians Pediatrics, October 1, 2004; 114(4): 1056 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. R. Stanton, M. Janda, P. D. Baade, and P. Anderson Primary prevention of skin cancer: a review of sun protection in Australia and internationally Health Promot. Int., September 1, 2004; 19(3): 369 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Naeyaert and L. Brochez Dysplastic Nevi N. Engl. J. Med., December 4, 2003; 349(23): 2233 - 2240. [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Balk Sun sense: Advise families on how to protect children from sunburn, skin cancer AAP News, July 1, 2002; 21(1): 16 - 20. [Full Text] [PDF]
|
|
|
|
|
|
D. B. Buller, A. C. Geller, M. Cantor, M. K. Buller, K. Rosseel, D. Hufford, L. Benjes, and R. A. Lew Sun Protection Policies and Environmental Features in US Elementary Schools Arch Dermatol, June 1, 2002; 138(6): 771 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Krowchuk Sun Protection for Children: What Parents Do AAP Grand Rounds, November 1, 2001; 6(5): 55 - 56. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Johnson, L. Davy, T. Boyett, L. Weathers, and R. G. Roetzheim Sun Protection Practices for Children: Knowledge, Attitudes, and Parent Behaviors Arch Pediatr Adolesc Med, August 1, 2001; 155(8): 891 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Barzilai, R. P. Gallagher, C. D. Bajdik, T. K. Lee, J. K. Rivers, D. I. McLean, and A. J. Coldman Efficacy of Sunscreen in Preventing Nevi JAMA, December 13, 2000; 284(22): 2870 - 2870. [Full Text] [PDF]
|
|
|
|
|
|
D. S. Rigel, M. Naylor, and J. Robinson What Is the Evidence for a Sunscreen and Melanoma Controversy? Arch Dermatol, December 1, 2000; 136(12): 1447 - 1449. [Full Text] [PDF]
|
|
|
|
|
|
R. P. Gallagher, J. K. Rivers, T. K. Lee, C. D. Bajdik, D. I. McLean, and A. J. Coldman Broad-Spectrum Sunscreen Use and the Development of New Nevi in White Children: A Randomized Controlled Trial JAMA, June 14, 2000; 283(22): 2955 - 2960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Autier Sunscreen and Melanoma Revisited Arch Dermatol, March 1, 2000; 136(3): 423 - 423. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Autier, J.-F. Dore, S. Negrier, D. Lienard, R. Panizzon, F. J. Lejeune, D. Guggisberg, and A. M. M. Eggermont Sunscreen Use and Duration of Sun Exposure: a Double-Blind, Randomized Trial J Natl Cancer Inst, August 4, 1999; 91(15): 1304 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Autier, J.-F. Dore, and G. Severi RESPONSE: More About: Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old European Children J Natl Cancer Inst, July 7, 1999; 91(13): 1165 - 1166. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Elwood and R. P. Gallagher More About: Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old European Children J Natl Cancer Inst, July 7, 1999; 91(13): 1164a - 1166a. [Full Text] [PDF]
|
|
|
|
|
|
F. P. Gasparro and M. Berwick Re: Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old European Children J Natl Cancer Inst, June 16, 1999; 91(12): 1078 - 1079. [Full Text] [PDF]
|
|
|
|
|
|
P. Autier and J.-F. Dore RESPONSE: Re: Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old European Children J Natl Cancer Inst, June 16, 1999; 91(12): 1079 - 1080. [Full Text] [PDF]
|
|