© 1998 by Oxford University Press
Journal Of The National Cancer Institute, Vol 90, 150-155, Copyright © 1998 by Oxford University Press
WH Chow, WJ Blot, TL Vaughan, HA Risch, MD Gammon, JL Stanford, R Dubrow, JB Schoenberg, ST Mayne, DC Farrow, H Ahsan, AB West, H Rotterdam, S Niwa and JF Fraumeni Jr
BACKGROUND: Incidence rates have risen rapidly for esophageal
adenocarcinoma and moderately for gastric cardia adenocarcinoma, while
rates have remained stable for esophageal squamous cell carcinoma and have
declined steadily for noncardia gastric adenocarcinoma. We examined
anthropometric risk factors in a population-based case-control study of
esophageal and gastric cancers in Connecticut, New Jersey, and western
Washington. METHODS: Healthy control subjects (n = 695) and case patients
with esophageal squamous cell carcinoma or noncardia gastric adenocarcinoma
(n = 589) were frequency-matched to case patients with adenocarcinomas of
esophagus or gastric cardia (n = 554) by 5-year age groups, sex, and race
(New Jersey only). Classification of cases by tumor site of origin and
histology was determined by review of pathology materials and hospital
records. Data were collected using in-person structured interviews.
Associations with obesity, measured by body mass index (BMI), were
estimated by odds ratios (ORs). All ORs were adjusted for geographic
location, age, sex, race, cigarette smoking, and proxy response status.
RESULTS: The ORs for esophageal adenocarcinoma rose with increasing adult
BMI. The magnitude of association with BMI was greater among the younger
age groups and among nonsmokers. The ORs for gastric cardia adenocarcinoma
rose moderately with increasing BMI. Adult BMI was not associated with risk
of esophageal squamous cell carcinoma or noncardia gastric adenocarcinoma.
CONCLUSIONS: Increasing prevalence of obesity in the United States
population may have contributed to the upward trends in esophageal and
gastric cardia adenocarcinomas.
ARTICLES
Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Sadeghi, C. J. Bain, N. Pandeya, P. M. Webb, A. C. Green, D. C. Whiteman, and for the Australian Cancer Study Aspirin, Nonsteroidal Anti-inflammatory Drugs, and the Risks of Cancers of the Esophagus Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1169 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B J Kendall, G A Macdonald, N K Hayward, J B Prins, I Brown, N Walker, N Pandeya, A C Green, P M Webb, D C Whiteman, et al. Leptin and the risk of Barrett's oesophagus Gut, April 1, 2008; 57(4): 448 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. El-Serag Role of obesity in GORD-related disorders Gut, March 1, 2008; 57(3): 281 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Corley, A. Kubo, and W. Zhao Abdominal Obesity and the Risk of Esophageal and Gastric Cardia Carcinomas Cancer Epidemiol. Biomarkers Prev., February 1, 2008; 17(2): 352 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D C Whiteman, S Sadeghi, N Pandeya, B M Smithers, D C Gotley, C J Bain, P M Webb, A C Green, and for the Australian Cancer Study Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus Gut, February 1, 2008; 57(2): 173 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sjodahl, C. Jia, L. Vatten, T. Nilsen, K. Hveem, and J. Lagergren Body Mass and Physical Activity and Risk of Gastric Cancer in a Population-Based Cohort Study in Norway Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 135 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K Reeves, K. Pirie, V. Beral, J. Green, E. Spencer, D. Bull, and Million Women Study Collaboration Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study BMJ, December 1, 2007; 335(7630): 1134 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Siahpush, T. L. Vaughan, J. N. Lampe, R. Freeman, S. Lewis, R. D. Odze, P. L. Blount, K. Ayub, P. S. Rabinovitch, B. J. Reid, et al. Longitudinal Study of Insulin-like Growth Factor, Insulin-like Growth Factor Binding Protein-3, and their Polymorphisms: Risk of Neoplastic Progression in Barrett's Esophagus Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2387 - 2395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Healy, A. M. Ryan, B. Gopinath, S. Rowley, P. J. Byrne, and J. V. Reynolds Impact of obesity on outcomes in the management of localized adenocarcinoma of the esophagus and esophagogastric junction. J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1284 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H H Merry, L. J Schouten, R A. Goldbohm, and P. A van den Brandt Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: a prospective cohort study Gut, November 1, 2007; 56(11): 1503 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S-N Wang, S-C Chuang, Y-T Yeh, S-F Yang, C-Y Chai, W-T Chen, K-K Kuo, J-S Chen, and K-T Lee Potential prognostic value of leptin receptor in hepatocellular carcinoma J. Clin. Pathol., December 1, 2006; 59(12): 1267 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Chao, C. C. Maley, X. Wu, D. C. Farrow, P. C. Galipeau, C. A. Sanchez, T. G. Paulson, P. S. Rabinovitch, B. J. Reid, M. R. Spitz, et al. Mutagen Sensitivity and Neoplastic Progression in Patients with Barrett's Esophagus: A Prospective Analysis. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1935 - 1940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ye, R. Kumar, G. Bacova, J. Lagergren, K. Hemminki, and O. Nyren The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden Carcinogenesis, September 1, 2006; 27(9): 1835 - 1841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lagergren, P. Viklund, and C. Jansson Carbonated soft drinks and risk of esophageal adenocarcinoma: a population-based case-control study. J Natl Cancer Inst, August 16, 2006; 98(16): 1158 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Kelloff, S. M. Lippman, A. J. Dannenberg, C. C. Sigman, H. L. Pearce, B. J. Reid, E. Szabo, V. C. Jordan, M. R. Spitz, G. B. Mills, et al. Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer--A Plan to Move Forward Clin. Cancer Res., June 15, 2006; 12(12): 3661 - 3697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Kamangar, G. M. Dores, and W. F. Anderson Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World J. Clin. Oncol., May 10, 2006; 24(14): 2137 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kubo and D. A. Corley Body Mass Index and Adenocarcinomas of the Esophagus or Gastric Cardia: A Systematic Review and Meta-analysis. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 872 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Jansson, N Plato, A L V Johansson, O Nyren, and J Lagergren Airborne occupational exposures and risk of oesophageal and cardia adenocarcinoma Occup. Environ. Med., February 1, 2006; 63(2): 107 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Chapman, D. M. Mannino, J. B. Soriano, P. A. Vermeire, A. S. Buist, M. J. Thun, C. Connell, A. Jemal, T. A. Lee, M. Miravitlles, et al. Epidemiology and costs of chronic obstructive pulmonary disease Eur. Respir. J., January 1, 2006; 27(1): 188 - 207. [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. DeMeester Adenocarcinoma of the Esophagus and Cardia: A Review of the Disease and Its Treatment Ann. Surg. Oncol., January 1, 2006; 13(1): 12 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Smith, S. M. O'Brien, B. M. Smithers, D. C. Gotley, P. M. Webb, A. C. Green, D. C. Whiteman, and for the Study of Digestive Health Interactions among Smoking, Obesity, and Symptoms of Acid Reflux in Barrett's Esophagus Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2481 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Kristal, P. L. Blount, J. M. Schenk, C. A. Sanchez, P. S. Rabinovitch, R. D. Odze, J. Standley, T. L. Vaughan, and B. J. Reid Low-Fat, High Fruit and Vegetable Diets and Weight Loss Do Not Affect Biomarkers of Cellular Proliferation in Barrett Esophagus Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2377 - 2383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hampel, N. S. Abraham, and H. B. El-Serag Meta-Analysis: Obesity and the Risk for Gastroesophageal Reflux Disease and Its Complications Ann Intern Med, August 2, 2005; 143(3): 199 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E M van Soest, J P Dieleman, P D Siersema, M C J M Sturkenboom, and E J Kuipers Increasing incidence of Barrett's oesophagus in the general population Gut, August 1, 2005; 54(8): 1062 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Oh, Y. S. Yoon, and S.-A. Shin Effects of Excess Weight on Cancer Incidences Depending on Cancer Sites and Histologic Findings Among Men: Korea National Health Insurance Corporation Study J. Clin. Oncol., July 20, 2005; 23(21): 4742 - 4754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jansson, A. L.V. Johansson, O. Nyren, and J. Lagergren Socioeconomic Factors and Risk of Esophageal Adenocarcinoma: A Nationwide Swedish Case-Control Study Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1754 - 1761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Yao, J. F. Tseng, S. Worah, K. R. Hess, P. F. Mansfield, C. H. Crane, I. I. Schnirer, S. Reddy, S. S. Chiang, A. Najam, et al. Clinicopathologic Behavior of Gastric Adenocarcinoma in Hispanic Patients: Analysis of a Single Institution's Experience Over 15 Years J. Clin. Oncol., May 1, 2005; 23(13): 3094 - 3103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani Global Cancer Statistics, 2002 CA Cancer J Clin, March 1, 2005; 55(2): 74 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Lagergren Adenocarcinoma of oesophagus: what exactly is the size of the problem and who is at risk? Gut, March 1, 2005; 54(suppl_1): i1 - i5. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ishikawa, J. Kitayama, S. Kazama, T. Hiramatsu, K. Hatano, and H. Nagawa Plasma Adiponectin and Gastric Cancer Clin. Cancer Res., January 15, 2005; 11(2): 466 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Marsman, R. S. Birjmohun, B. P. van Rees, E. Caspers, G. Johan, A. Offerhaus, P. J. Bosma, J. Jan, and B. van Lanschot Loss of Heterozygosity and Immunohistochemistry of Adenocarcinomas of the Esophagus and Gastric Cardia Clin. Cancer Res., December 15, 2004; 10(24): 8479 - 8485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W J Lee, W Lijinsky, E F Heineman, R S Markin, D D Weisenburger, and M H Ward Agricultural pesticide use and adenocarcinomas of the stomach and oesophagus Occup. Environ. Med., September 1, 2004; 61(9): 743 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, S. Kaneko, and T. Sobue Trends in reported incidences of gastric cancer by tumour location, from 1975 to 1989 in Japan Int. J. Epidemiol., August 1, 2004; 33(4): 808 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Polee, A. Sparreboom, F. A. L. M. Eskens, R. Hoekstra, J. van de Schaaf, J. Verweij, G. Stoter, and A. van der Gaast A Phase I and Pharmacokinetic Study of Weekly Paclitaxel and Carboplatin in Patients with Metastatic Esophageal Cancer Clin. Cancer Res., March 15, 2004; 10(6): 1928 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. McManus, A. Olaru, and S. J. Meltzer Biomarkers of Esophageal Adenocarcinoma and Barrett's Esophagus Cancer Res., March 1, 2004; 64(5): 1561 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Gammon, M. B. Terry, N. Arber, W.-H. Chow, H. A. Risch, T. L. Vaughan, J. B. Schoenberg, S. T. Mayne, J. L. Stanford, R. Dubrow, et al. Nonsteroidal Anti-inflammatory Drug Use Associated with Reduced Incidence of Adenocarcinomas of the Esophagus and Gastric Cardia that Overexpress Cyclin D1: A Population-Based Study Cancer Epidemiol. Biomarkers Prev., January 1, 2004; 13(1): 34 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Enzinger and R. J. Mayer Esophageal Cancer N. Engl. J. Med., December 4, 2003; 349(23): 2241 - 2252. [Full Text] [PDF]
|
|
|
|
|
|
C J Buskens, A Sivula, B P van Rees, C Haglund, G J A Offerhaus, J J B van Lanschot, and A Ristimaki Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus Gut, December 1, 2003; 52(12): 1678 - 1683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Engel, W.-H. Chow, T. L. Vaughan, M. D. Gammon, H. A. Risch, J. L. Stanford, J. B. Schoenberg, S. T. Mayne, R. Dubrow, H. Rotterdam, et al. Population Attributable Risks of Esophageal and Gastric Cancers J Natl Cancer Inst, September 17, 2003; 95(18): 1404 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Murray, B. Johnston, A. Lane, I. Harvey, J. Donovan, P. Nair, and R. Harvey Relationship between body mass and gastro-oesophageal reflux symptoms: The Bristol Helicobacter Project Int. J. Epidemiol., August 1, 2003; 32(4): 645 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nilsson, R. Johnsen, W. Ye, K. Hveem, and J. Lagergren Obesity and Estrogen as Risk Factors for Gastroesophageal Reflux Symptoms JAMA, July 2, 2003; 290(1): 66 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Rudolph, T. L. Vaughan, A. R. Kristal, P. L. Blount, D. S. Levine, P. C. Galipeau, L. J. Prevo, C. A. Sanchez, P. S. Rabinovitch, and B. J. Reid Serum Selenium Levels in Relation to Markers of Neoplastic Progression Among Persons With Barrett's Esophagus J Natl Cancer Inst, May 21, 2003; 95(10): 750 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Calle, C. Rodriguez, K. Walker-Thurmond, and M. J. Thun Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults N. Engl. J. Med., April 24, 2003; 348(17): 1625 - 1638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Mayne and S. A. Navarro Diet, Obesity and Reflux in the Etiology of Adenocarcinomas of the Esophagus and Gastric Cardia in Humans J. Nutr., November 1, 2002; 132(11): 3467S - 3470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Chak, T Lee, M F Kinnard, W Brock, A Faulx, J Willis, G S Cooper, M V Sivak Jr, and K A B Goddard Familial aggregation of Barrett's oesophagus, oesophageal adenocarcinoma, and oesophagogastric junctional adenocarcinoma in Caucasian adults Gut, September 1, 2002; 51(3): 323 - 328. [Abstract] [Full Text]
|
|
|
|
|
|
T. L. Vaughan, A. R. Kristal, P. L. Blount, D. S. Levine, P. C. Galipeau, L. J. Prevo, C. A. Sanchez, P. S. Rabinovitch, and B. J. Reid Nonsteroidal Anti-inflammatory Drug Use, Body Mass Index, and Anthropometry in Relation to Genetic and Flow Cytometric Abnormalities in Barrett's Esophagus Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 745 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shaheen and D. F. Ransohoff Gastroesophageal Reflux, Barrett Esophagus, and Esophageal Cancer: Scientific Review JAMA, April 17, 2002; 287(15): 1972 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H B El-Serag, A C Mason, N Petersen, and C R Key Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA Gut, March 1, 2002; 50(3): 368 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Jacobs, C. J. Connell, M. L. McCullough, A. Chao, C. R. Jonas, C. Rodriguez, E. E. Calle, and M. J. Thun Vitamin C, Vitamin E, and Multivitamin Supplement Use and Stomach Cancer Mortality in the Cancer Prevention Study II Cohort Cancer Epidemiol. Biomarkers Prev., January 1, 2002; 11(1): 35 - 41. [Abstract] [Full Text]
|
|
|
|
|
|
S. T. Mayne, H. A. Risch, R. Dubrow, W.-H. Chow, M. D. Gammon, T. L. Vaughan, D. C. Farrow, J. B. Schoenberg, J. L. Stanford, H. Ahsan, et al. Nutrient Intake and Risk of Subtypes of Esophageal and Gastric Cancer Cancer Epidemiol. Biomarkers Prev., October 1, 2001; 10(10): 1055 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Conio, A J Cameron, Y Romero, C D Branch, C D Schleck, L J Burgart, A R Zinsmeister, L J Melton III, and G R Locke III Secular trends in the epidemiology and outcome of Barrett's oesophagus in Olmsted County, Minnesota Gut, March 1, 2001; 48(3): 304 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Mark, Y.-L. Qiao, S. M. Dawsey, Y.-P. Wu, H. Katki, E. W. Gunter, J. F. Fraumeni Jr., W. J. Blot, Z.-W. Dong, and P. R. Taylor Prospective Study of Serum Selenium Levels and Incident Esophageal and Gastric Cancers J Natl Cancer Inst, November 1, 2000; 92(21): 1753 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Metayer, C. F. Lynch, E. A. Clarke, B. Glimelius, H. Storm, E. Pukkala, T. Joensuu, F. E. van Leeuwen, M. B. van't Veer, R. E. Curtis, et al. Second Cancers Among Long-Term Survivors of Hodgkin's Disease Diagnosed in Childhood and Adolescence J. Clin. Oncol., June 12, 2000; 18(12): 2435 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. T. Johnston The significance of heartburn QJM, June 1, 2000; 93(6): 321 - 322. [Full Text] [PDF]
|
|
|
|
|
|
R. E. Rudolph, T. L. Vaughan, B. E. Storer, R. C. Haggitt, P. S. Rabinovitch, D. S. Levine, and B. J. Reid Effect of Segment Length on Risk for Neoplastic Progression in Patients with Barrett Esophagus Ann Intern Med, April 18, 2000; 132(8): 612 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lagergren, R. Bergstrom, and O. Nyren Association between Body Mass and Adenocarcinoma of the Esophagus and Gastric Cardia Ann Intern Med, June 1, 1999; 130(11): 883 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Devesa and J. F. Fraumeni , Jr. The Rising Incidence of Gastric Cardia Cancer J Natl Cancer Inst, May 5, 1999; 91(9): 747 - 749. [Full Text] [PDF]
|
|
|
|
|
|
J. Lagergren, R. Bergstrom, A. Lindgren, and O. Nyren Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma N. Engl. J. Med., March 18, 1999; 340(11): 825 - 831. [Abstract] [Full Text] [PDF]
|
|