© 1998 by Oxford University Press
Journal Of The National Cancer Institute, Vol 90, 911-915, Copyright © 1998 by Oxford University Press
A Wolk, CS Mantzoros, SO Andersson, R Bergstrom, LB Signorello, P Lagiou, HO Adami and D Trichopoulos
BACKGROUND: Recent epidemiologic investigations have suggested an
association between increased blood levels of insulin-like growth factor 1
(IGF-1) and increased risk of prostate cancer. Our goal was to determine
whether an association exists between serum levels of IGF-1 and one of its
binding proteins, insulin-like growth factor-binding protein 3 (IGFBP-3),
and prostate cancer risk. METHODS: An immunoradiometric assay was used to
quantify IGF-1 levels and IGFBP-3 levels in serum samples as part of a
population-based, case-control study in Sweden. The study population
comprised 210 patients with newly diagnosed, untreated prostate cancer and
224 frequency-matched control subjects. Data were analyzed by use of
unconditional logistic regression to calculate odds ratios (ORs) and 95%
confidence intervals (CIs). Reported P values are two-sided. RESULTS: The
mean serum IGF-1 level for case patients (158.4 ng/mL) was significantly
higher than that for control subjects (147.4 ng/mL) (P = .02);
corresponding mean serum IGFBP-3 levels were not significantly different
between case patients (2668 ng/mL) and control subjects (2518 ng/mL) (P
=.09). We found a moderately strong and statistically significant (P = .04)
positive association between serum levels of IGF-1 levels and risk of
prostate cancer (OR = 1.51; 95% CI = 1.0-2.26 per 100 ng/mL increment); the
association was particularly strong for men younger than 70 years of age
(OR = 2.93; 95% CI = 1.43-5.97). No association was found between serum
IGF-1 levels and disease stage. Serum IGFBP-3 levels were not significantly
associated with increased risk of disease, and adjustment for IGFBP-3 had
little effect on the association between IGF- 1 levels and risk of prostate
cancer. CONCLUSION: Elevated serum IGF-1 levels may be an important
predictor of risk for prostate cancer. However, our results do not support
an important role for serum IGFBP-3 as a predictor of risk for this
disease.
ARTICLES
Insulin-like growth factor 1 and prostate cancer risk: a population- based, case-control study
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden. Alicja.Wolk@mep.ki.se
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M. D. Holmes, M. N. Pollak, W. C. Willett, and S. E. Hankinson Dietary Correlates of Plasma Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 852 - 861. [Abstract] [Full Text] [PDF]
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M. D. Holmes, M. N. Pollak, and S. E. Hankinson Lifestyle Correlates of Plasma Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations Cancer Epidemiol. Biomarkers Prev., September 1, 2002; 11(9): 862 - 867. [Abstract] [Full Text] [PDF]
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S. Chang, X. Wu, H. Yu, and M. R. Spitz Plasma Concentrations of Insulin-like Growth Factors among Healthy Adult Men and Postmenopausal Women: Associations with Body Composition, Lifestyle, and Reproductive Factors Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 758 - 766. [Abstract] [Full Text] [PDF]
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J. M. Chan, M. J. Stampfer, J. Ma, P. Gann, J. M. Gaziano, M. Pollak, and E. Giovannucci Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 as Predictors of Advanced-Stage Prostate Cancer J Natl Cancer Inst, July 17, 2002; 94(14): 1099 - 1106. [Abstract] [Full Text] [PDF]
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G. G. Giles, G. Severi, R. Sinclair, D. R. English, M. R. E. McCredie, W. Johnson, P. Boyle, and J. L. Hopper Androgenetic Alopecia and Prostate Cancer: Findings from an Australian Case-Control Study Cancer Epidemiol. Biomarkers Prev., June 1, 2002; 11(6): 549 - 553. [Abstract] [Full Text] [PDF]
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R. E. Schoen, J. Schragin, J. L. Weissfeld, F. L. Thaete, R. W. Evans, C. J. Rosen, and L. H. Kuller Lack of Association between Adipose Tissue Distribution and IGF-1 and IGFBP-3 in Men and Women Cancer Epidemiol. Biomarkers Prev., June 1, 2002; 11(6): 581 - 586. [Abstract] [Full Text] [PDF]
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G. O. Hellawell, G. D. H. Turner, D. R. Davies, R. Poulsom, S. F. Brewster, and V. M. Macaulay Expression of the Type 1 Insulin-like Growth Factor Receptor Is Up-Regulated in Primary Prostate Cancer and Commonly Persists in Metastatic Disease Cancer Res., May 1, 2002; 62(10): 2942 - 2950. [Abstract] [Full Text] [PDF]
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P. Muti, P. Gaddi, and T. Quattrin Correspondence re: Chokkalingam A. et al., Insulin-like Growth Factors and Prostate Cancer: A Population-based Case-Control Study in China. Cancer Epidemiol. Biomark. Prev., 10: 421-427, 2001 Cancer Epidemiol. Biomarkers Prev., March 1, 2002; 11(3): 323 - 323. [Full Text] [PDF]
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S. F. Shariat, D. J. Lamb, M. W. Kattan, C. Nguyen, J. Kim, J. Beck, T. M. Wheeler, and K. M. Slawin Association of Preoperative Plasma Levels of Insulin-Like Growth Factor I and Insulin-Like Growth Factor Binding Proteins-2 and -3 With Prostate Cancer Invasion, Progression, and Metastasis J. Clin. Oncol., February 1, 2002; 20(3): 833 - 841. [Abstract] [Full Text] [PDF]
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Y. Wu, S. Yakar, L. Zhao, L. Hennighausen, and D. LeRoith Circulating Insulin-like Growth Factor-I Levels Regulate Colon Cancer Growth and Metastasis Cancer Res., February 1, 2002; 62(4): 1030 - 1035. [Abstract] [Full Text] [PDF]
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G. Frajese, W. M. Drake, R. A. Loureiro, J. Evanson, D. Coyte, D. F. Wood, A. B. Grossman, G. M. Besser, and J. P. Monson Hypothalamo-Pituitary Surveillance Imaging in Hypopituitary Patients Receiving Long-Term GH Replacement Therapy J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5172 - 5175. [Abstract] [Full Text] [PDF]
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S. W. Hayward, Y. Wang, M. Cao, Y. K. Hom, B. Zhang, G. D. Grossfeld, D. Sudilovsky, and G. R. Cunha Malignant Transformation in a Nontumorigenic Human Prostatic Epithelial Cell Line Cancer Res., November 1, 2001; 61(22): 8135 - 8142. [Abstract] [Full Text] [PDF]
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J. V. Lacey Jr., A. W. Hsing, C.-M. Fillmore, S. Hoffman, K. J. Helzlsouer, and G. W. Comstock Null Association between Insulin-like Growth Factors, Insulin-like Growth Factor-binding Proteins, and Prostate Cancer in a Prospective Study Cancer Epidemiol. Biomarkers Prev., October 1, 2001; 10(10): 1101 - 1102. [Full Text] [PDF]
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O. Kucuk, F. H. Sarkar, W. Sakr, Z. Djuric, M. N. Pollak, F. Khachik, Y.-W. Li, M. Banerjee, D. Grignon, J. S. Bertram, et al. Phase II Randomized Clinical Trial of Lycopene Supplementation before Radical Prostatectomy Cancer Epidemiol. Biomarkers Prev., August 1, 2001; 10(8): 861 - 868. [Abstract] [Full Text] [PDF]
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W. M. Drake, S. J. Howell, J. P. Monson, and S. M. Shalet Optimizing GH Therapy in Adults and Children Endocr. Rev., August 1, 2001; 22(4): 425 - 450. [Abstract] [Full Text] [PDF]
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S. Melmed CLINICAL PERSPECTIVE: Acromegaly and Cancer: Not a Problem? J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 2929 - 2934. [Full Text] [PDF]
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P. J. Jenkins and M. Besser CLINICAL PERSPECTIVE: Acromegaly and Cancer: A Problem J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 2935 - 2941. [Full Text] [PDF]
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A. W. Hsing, S. Chua Jr, Y.-T. Gao, E. Gentzschein, L. Chang, J. Deng, and F. Z. Stanczyk Prostate Cancer Risk and Serum Levels of Insulin and Leptin: a Population-Based Study J Natl Cancer Inst, May 16, 2001; 93(10): 783 - 789. [Abstract] [Full Text] [PDF]
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A. P. Chokkalingam, M. Pollak, C.-M. Fillmore, Y.-T. Gao, F. Z. Stanczyk, J. Deng, I. A. Sesterhenn, F. K. Mostofi, T. R. Fears, M. P. Madigan, et al. Insulin-like Growth Factors and Prostate Cancer: A Population-based Case-Control Study in China Cancer Epidemiol. Biomarkers Prev., May 1, 2001; 10(5): 421 - 427. [Abstract] [Full Text]
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V. L Freeman, M. Meydani, S. Yong, J. Pyle, R. Durazo-Arvizu, Y. Liao, R. C Flanigan, and W B. Waters Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? Am. J. Clinical Nutrition, April 1, 2001; 73(4): 815 - 820. [Abstract] [Full Text] [PDF]
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P. Stattin, S. Söderberg, G. Hallmans, A. Bylund, R. Kaaks, U.-H. Stenman, A. Bergh, and T. Olsson Leptin Is Associated with Increased Prostate Cancer Risk: A Nested Case-Referent Study J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1341 - 1345. [Abstract] [Full Text]
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E. M. Erfurth, B. Bülow, Z. Mikoczy, and L. Hagmar Incidence of a Second Tumor in Hypopituitary Patients Operated for Pituitary Tumors J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 659 - 662. [Abstract] [Full Text]
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J. Khosravi, A. Diamandi, J. Mistry, and A. Scorilas Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3 in Benign Prostatic Hyperplasia and Prostate Cancer J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 694 - 699. [Abstract] [Full Text]
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S. E. Damon, S. R. Plymate, J. M. Carroll, C. C. Sprenger, C. Dechsukhum, J. L. Ware, and C. T. Roberts Jr. Transcriptional Regulation of Insulin-Like Growth Factor-I Receptor Gene Expression in Prostate Cancer Cells Endocrinology, January 1, 2001; 142(1): 21 - 27. [Abstract] [Full Text] [PDF]
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E. A. Platz, E. B. Rimm, W. C. Willett, P. W. Kantoff, and E. Giovannucci Racial Variation in Prostate Cancer Incidence and in Hormonal System Markers Among Male Health Professionals J Natl Cancer Inst, December 20, 2000; 92(24): 2009 - 2017. [Abstract] [Full Text] [PDF]
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P. Stattin, A. Bylund, S. Rinaldi, C. Biessy, H. Dechaud, U.-H. Stenman, L. Egevad, E. Riboli, G. Hallmans, and R. Kaaks Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study J Natl Cancer Inst, December 6, 2000; 92(23): 1910 - 1917. [Abstract] [Full Text] [PDF]
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S. M. Harman, E. J. Metter, M. R. Blackman, P. K. Landis, and H. B. Carter Serum Levels of Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, and Prostate-Specific Antigen as Predictors of Clinical Prostate Cancer J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4258 - 4265. [Abstract] [Full Text]
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A. Colao, P. Marzullo, S. Spiezia, A. Giaccio, D. Ferone, G. Cerbone, A. Di Sarno, and G. Lombardi Effect of Two Years of Growth Hormone and Insulin-Like Growth Factor-I Suppression on Prostate Diseases in Acromegalic Patients J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3754 - 3761. [Abstract] [Full Text]
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H. Yu and T. Rohan Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression J Natl Cancer Inst, September 20, 2000; 92(18): 1472 - 1489. [Abstract] [Full Text] [PDF]
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A. G. Renehan, J. E. Painter, D. O’Halloran, W. S. Atkin, C. S. Potten, S. T. O’Dwyer, and S. M. Shalet Circulating Insulin-Like Growth Factor II and Colorectal Adenomas J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3402 - 3408. [Abstract] [Full Text]
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P. Finne, A. Auvinen, H. Koistinen, W.-M. Zhang, L. Määttänen, S. Rannikko, T. Tammela, M. Seppälä, M. Hakama, and U.-H. Stenman Insulin-Like Growth Factor I Is Not a Useful Marker of Prostate Cancer in Men with Elevated Levels of Prostate-Specific Antigen J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2744 - 2747. [Abstract] [Full Text]
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M. S. Steiner, X. Zhang, Y. Wang, and Y. Lu Growth Inhibition of Prostate Cancer by an Adenovirus Expressing a Novel Tumor Suppressor Gene, pHyde Cancer Res., August 1, 2000; 60(16): 4419 - 4425. [Abstract] [Full Text]
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O. Akre, A. Ekbom, P. Sparen, and S. Tretli Body Size and Testicular Cancer J Natl Cancer Inst, July 5, 2000; 92(13): 1093 - 1096. [Full Text] [PDF]
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H. M. Khandwala, I. E. McCutcheon, A. Flyvbjerg, and K. E. Friend The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth Endocr. Rev., June 1, 2000; 21(3): 215 - 244. [Abstract] [Full Text]
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