© 1995 by Oxford University Press
Journal of the National Cancer Institute, Vol. 87, No. 11, 796-802,
June 7, 1995
© 1995 Oxford University Press
Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective
Servei d'Epidemiologia i Registre del Càncer, Institut Catala d'Oncologia Hospital Duran i Reynals, CSUB, Autovia Castelldefels, km. 2.7, E-08907 L'Hospitalet del Llobregat, Barcelona, Spain
Department of Molecular Microbiology and Immunology, School of Public Health, Johns Hopkins University University, Baltimore, Md.
Unit of Field and Intervention Studies, International Agency for Research on Cancer Lyon, France
Department of Pathology, Johns Hopkins Medical Institutions Bethesda, Md.
Institute of Cancer Research Belmont, Surrey, England
Environmental Epidemiology Branch, National Cancer Institute Bethesda, Md.
Nubia Muñoz, M.D., International Agency for Research on Cancer, 150, Cours Albert Thomas, F-69372 Lyon Cedex 08, France
BACKGROUND: Epidemiologic studies have shown that the association of genital human papillomavirus (HPV) with cervical cancer is strong, independent of other risk factors, and consistent in several countries. There are more than 20 different cancer-associated HPV types, but little is known about their geographic variation.
PURPOSE: Our aim was to determine whether the association between HPV infection and cervical cancer is consistent worldwide and to investigate geographic variation in the distribution of HPV types.
METHODS: More than 1000 specimens from sequential patients with invasive cervical cancer were collected and stored frozen at 32 hospitals in 22 countries. Slides from all patients were submitted for central histologic review to confirm the diagnosis and to assess histologic characteristics. We used polymerase chain reaction-based assays capable of detecting more than 25 different HPV types. A generalized linear Poisson model was fitted to the data on viral type and geographic region to assess geographic heterogeneity.
RESULTS: HPV DNA was detected in 93% of the tumors, with no significant variation in HPV positivity among countries. HPV 16 was present in 50% of the specimens, HPV 18 in 14%, HPV 45 in 8%, and HPV 31 in 5%. HPV 16 was the predominant type in all countries except Indonesia, where HPV 18 was more common. There was significant geographic variation in the prevalence of some less common virus types. A clustering of HPV 45 was apparent in western Africa, while HPV 39 and HPV 59 were almost entirely confined to Central and South America. In squamous cell tumors, HPV 16 predominated (51% of such specimens), but HPV 18 predominated in adenocarcinomas (56% of such tumors) and adenosquamous tumors (39% of such tumors).
CONCLUSIONS: Our results confirm the role of genital HPVs, which are transmitted sexually, as the central etiologic factor in cervical cancer worldwide. They also suggest that most genital HPVs are associated with cancer, at least occasionally.
IMPLICATION: The demonstration that more than 20 different genital HPV types are associated with cervical cancer has important implications for cervical cancer-prevention strategies that include the development of vaccines targeted to genital HPVs. [J Natl Cancer Inst 87:796–802, 1995]
CiteULike 
Connotea 
Del.icio.us What's this?
Online Perspective about this Classic Article
- Epidemiologic Studies of a Necessary Causal Risk Factor: Human Papillomavirus Infection and Cervical Neoplasia
- Mark H. Schiffman and Philip Castle
J Natl Cancer Inst 2003 95: 2E.[Extract] [Full Text]
This article has been cited by other articles:
|
|
 |
|
  C. E. Lange, K. Tobler, M. Ackermann, L. Panakova, K. L. Thoday, and C. Favrot Three novel canine papillomaviruses support taxonomic clade formation J. Gen. Virol., November 1, 2009; 90(11): 2615 - 2621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Karim, E. S. Jordanova, S. J. Piersma, G. G. Kenter, L. Chen, J. M. Boer, C. J. M. Melief, and S. H. van der Burg Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+ T-Cell Infiltration and Survival of Patients with Cervical Carcinoma Clin. Cancer Res., October 15, 2009; 15(20): 6341 - 6347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Smith, B. L. Meisenburg, V. L. Tam, R. R. Pagarigan, R. Wong, D. K. Joea, L. Lantzy, M. A. Carrillo, T. M. Gross, U. M. Malyankar, et al. Lymph Node-Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus-Transformed Tumors Clin. Cancer Res., October 1, 2009; 15(19): 6167 - 6176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schadlich, T. Senger, B. Gerlach, N. Mucke, C. Klein, I. G. Bravo, M. Muller, and L. Gissmann Analysis of Modified Human Papillomavirus Type 16 L1 Capsomeres: the Ability To Assemble into Larger Particles Correlates with Higher Immunogenicity J. Virol., August 1, 2009; 83(15): 7690 - 7705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. ADAMOPOULOU, E. KALKANI, E. CHARVALOS, D. AVGOUSTIDIS, D. HAIDOPOULOS, and C. YAPIJAKIS Comparison of Cytology, Colposcopy, HPV Typing and Biomarker Analysis in Cervical Neoplasia Anticancer Res, August 1, 2009; 29(8): 3401 - 3409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Cattani, A. Siddu, S. D'Onghia, S. Marchetti, R. Santangelo, V. G. Vellone, G. F. Zannoni, and G. Fadda RNA (E6 and E7) Assays versus DNA (E6 and E7) Assays for Risk Evaluation for Women Infected with Human Papillomavirus J. Clin. Microbiol., July 1, 2009; 47(7): 2136 - 2141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Jabbar, L. Abrams, A. Glick, and P. F. Lambert Persistence of High-Grade Cervical Dysplasia and Cervical Cancer Requires the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncogene Cancer Res., May 15, 2009; 69(10): 4407 - 4414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A.R. Tobian, D. Serwadda, T. C. Quinn, G. Kigozi, P. E. Gravitt, O. Laeyendecker, B. Charvat, V. Ssempijja, M. Riedesel, A. E. Oliver, et al. Male Circumcision for the Prevention of HSV-2 and HPV Infections and Syphilis N. Engl. J. Med., March 26, 2009; 360(13): 1298 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jiang, J. G. Baseman, L. A. Koutsky, Q. Feng, C. Mao, N. B. Kiviat, and L. F. Xi Sequence Variation of Human Papillomavirus Type 16 and Measurement of Viral Integration by Quantitative PCR J. Clin. Microbiol., March 1, 2009; 47(3): 521 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soderlund-Strand, J. Carlson, and J. Dillner Modified General Primer PCR System for Sensitive Detection of Multiple Types of Oncogenic Human Papillomavirus J. Clin. Microbiol., March 1, 2009; 47(3): 541 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. K. Cheung, T.-H. Cheung, C. W. Y. Ng, M. Y. Yu, M. C. S. Wong, S.-S. N. Siu, S.-F. Yim, and P. K. S. Chan Analysis of Human Papillomavirus Type 18 Load and Integration Status from Low-Grade Cervical Lesion to Invasive Cervical Cancer J. Clin. Microbiol., February 1, 2009; 47(2): 287 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Chen, R. DeSalle, M. Schiffman, R. Herrero, and R. D. Burk Evolutionary Dynamics of Variant Genomes of Human Papillomavirus Types 18, 45, and 97 J. Virol., February 1, 2009; 83(3): 1443 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N K S Wong, F Y Ng, and G Leung Cytological distinction between high-risk and low-risk human papillomavirus infections in SurePath liquid-based cell preparations J. Clin. Pathol., December 1, 2008; 61(12): 1317 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Hutchinson and K. C. Klein Human papillomavirus disease and vaccines Am. J. Health Syst. Pharm., November 15, 2008; 65(22): 2105 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Stevens, S. M. Garland, and S. N. Tabrizi Validation of an Automated Detection Platform for Use with the Roche Linear Array Human Papillomavirus Genotyping Test J. Clin. Microbiol., November 1, 2008; 46(11): 3813 - 3816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saunier, S. Monnier-Benoit, F. Mauny, V. Dalstein, J. Briolat, D. Riethmuller, B. Kantelip, E. Schwarz, C. Mougin, and J.-L. Pretet Analysis of Human Papillomavirus Type 16 (HPV16) DNA Load and Physical State for Identification of HPV16-Infected Women with High-Grade Lesions or Cervical Carcinoma J. Clin. Microbiol., November 1, 2008; 46(11): 3678 - 3685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Smith, S. K. Campos, A. Wandinger-Ness, and M. A. Ozbun Caveolin-1-Dependent Infectious Entry of Human Papillomavirus Type 31 in Human Keratinocytes Proceeds to the Endosomal Pathway for pH-Dependent Uncoating J. Virol., October 1, 2008; 82(19): 9505 - 9512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, D. Solomon, C. M. Wheeler, P. E. Gravitt, S. Wacholder, and M. Schiffman Human Papillomavirus Genotype Specificity of Hybrid Capture 2 J. Clin. Microbiol., August 1, 2008; 46(8): 2595 - 2604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. D. Caberg, P. M. Hubert, D. Y. Begon, M. F. Herfs, P. J. Roncarati, J. J. Boniver, and P. O. Delvenne Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes Carcinogenesis, July 1, 2008; 29(7): 1441 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Tornesello, M. L. Duraturo, P. Giorgi-Rossi, M. Sansone, R. Piccoli, L. Buonaguro, and F. M. Buonaguro Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women J. Gen. Virol., June 1, 2008; 89(6): 1380 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Chen, M.-R. Shen, Y.-J. Chen, M.-C. Maa, and T.-H. Leu Eps8 decreases chemosensitivity and affects survival of cervical cancer patients Mol. Cancer Ther., June 1, 2008; 7(6): 1376 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Gravitt, M. Schiffman, D. Solomon, C. M. Wheeler, and P. E. Castle A Comparison of Linear Array and Hybrid Capture 2 for Detection of Carcinogenic Human Papillomavirus and Cervical Precancer in ASCUS-LSIL Triage Study Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1248 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Ginocchio, D. Barth, and F. Zhang Comparison of the Third Wave Invader Human Papillomavirus (HPV) Assay and the Digene HPV Hybrid Capture 2 Assay for Detection of High-Risk HPV DNA J. Clin. Microbiol., May 1, 2008; 46(5): 1641 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Santin, S. Bellone, M. Palmieri, A. Zanolini, A. Ravaggi, E. R. Siegel, J. J. Roman, S. Pecorelli, and M. J. Cannon Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial J. Virol., February 15, 2008; 82(4): 1968 - 1979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Dekker Human Papillomavirus Vaccine Legislation in Kentucky: A Policy Analysis Policy Politics Nursing Practice, February 1, 2008; 9(1): 40 - 49. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Marais, D. Constant, B. Allan, H. Carrara, M. Hoffman, S. Shapiro, C. Morroni, and A.-L. Williamson Cervical Human Papillomavirus (HPV) Infection and HPV Type 16 Antibodies in South African Women J. Clin. Microbiol., February 1, 2008; 46(2): 732 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y P Bao, N Li, J S Smith, and Y L Qiao Human papillomavirus type-distribution in the cervix of Chinese women: a meta-analysis Int J STD AIDS, February 1, 2008; 19(2): 106 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Wang, R. Viscidi, K. C. Hwang, T. Y. Lin, C. J. Chen, L. M. Huang, H. H. Chen, and C. J. Chen Seroprevalence and Risk Factors for Human Papillomavirus in Taiwan J Trop Pediatr, February 1, 2008; 54(1): 14 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Goraczniak and S. I. Gunderson The Regulatory Element in the 3'-Untranslated Region of Human Papillomavirus 16 Inhibits Expression by Binding CUG-binding Protein 1 J. Biol. Chem., January 25, 2008; 283(4): 2286 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Iglar, S. Katyal, R. Matthew, and V. Dubey Complete health checkup for adults: Update on the Preventive Care Checklist Form(C) Can Fam Physician, January 1, 2008; 54(1): 84 - 88. [Full Text] [PDF]
|
|
|
|
|
|
M. Guo, Y. Gong, M. Deavers, E. G. Silva, Y. J. Jan, D. E. Cogdell, R. Luthra, E. Lin, H. C. Lai, W. Zhang, et al. Evaluation of a Commercialized In Situ Hybridization Assay for Detecting Human Papillomavirus DNA in Tissue Specimens from Patients with Cervical Intraepithelial Neoplasia and Cervical Carcinoma J. Clin. Microbiol., January 1, 2008; 46(1): 274 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, P. E. Gravitt, D. Solomon, C. M. Wheeler, and M. Schiffman Comparison of Linear Array and Line Blot Assay for Detection of Human Papillomavirus and Diagnosis of Cervical Precancer and Cancer in the Atypical Squamous Cell of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study J. Clin. Microbiol., January 1, 2008; 46(1): 109 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J.P. Welters, G. G. Kenter, S. J. Piersma, A. P.G. Vloon, M. J.G. Lowik, D. M.A. Berends-van der Meer, J. W. Drijfhout, A. R. P.M. Valentijn, A. R. Wafelman, J. Oostendorp, et al. Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine Clin. Cancer Res., January 1, 2008; 14(1): 178 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Soderlund-Strand, J. Dillner, and J. Carlson High-Throughput Genotyping of Oncogenic Human Papilloma Viruses with MALDI-TOF Mass Spectrometry Clin. Chem., January 1, 2008; 54(1): 86 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Howard and A. Lytwyn The HPV vaccine: An analysis of the FUTURE II study Can Fam Physician, December 1, 2007; 53(12): 2157 - 2159. [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Long III, N. N. I. Laack, and B. S. Gostout Prevention, Diagnosis, and Treatment of Cervical Cancer Mayo Clin. Proc., December 1, 2007; 82(12): 1566 - 1574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Smith, S. K. Campos, and M. A. Ozbun Human Papillomavirus Type 31 Uses a Caveolin 1- and Dynamin 2-Mediated Entry Pathway for Infection of Human Keratinocytes J. Virol., September 15, 2007; 81(18): 9922 - 9931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shrestha, C. Wang, B. Aissani, C. M. Wilson, J. Tang, and R. A. Kaslow Interleukin-10 Gene (IL10) Polymorphisms and Human Papillomavirus Clearance among Immunosuppressed Adolescents Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1626 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. van der Burg, S. J. Piersma, A. de Jong, J. M. van der Hulst, K. M. C. Kwappenberg, M. van den Hende, M. J. P. Welters, J. J. Van Rood, G. J. Fleuren, C. J. M. Melief, et al. Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens PNAS, July 17, 2007; 104(29): 12087 - 12092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Stevens, S. M. Garland, E. Rudland, J. Tan, M. A. Quinn, and S. N. Tabrizi Comparison of the Digene Hybrid Capture 2 Assay and Roche AMPLICOR and LINEAR ARRAY Human Papillomavirus (HPV) Tests in Detecting High-Risk HPV Genotypes in Specimens from Women with Previous Abnormal Pap Smear Results J. Clin. Microbiol., July 1, 2007; 45(7): 2130 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Goodman, Y. B. Shvetsov, K. McDuffie, L. R. Wilkens, X. Zhu, A. A. Franke, C. C. Bertram, B. Kessel, M. Bernice, C. Sunoo, et al. Hawaii Cohort Study of Serum Micronutrient Concentrations and Clearance of Incident Oncogenic Human Papillomavirus Infection of the Cervix Cancer Res., June 15, 2007; 67(12): 5987 - 5996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. E. Gallagher and S. Man Identification of HLA-DR1- and HLA-DR15-restricted human papillomavirus type 16 (HPV16) and HPV18 E6 epitopes recognized by CD4+ T cells from healthy young women J. Gen. Virol., May 1, 2007; 88(5): 1470 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Safaeian, R. Herrero, A. Hildesheim, W. Quint, E. Freer, L.-J. Van Doorn, C. Porras, S. Silva, P. Gonzalez, M. C. Bratti, et al. Comparison of the SPF10-LiPA System to the Hybrid Capture 2 Assay for Detection of Carcinogenic Human Papillomavirus Genotypes among 5,683 Young Women in Guanacaste, Costa Rica J. Clin. Microbiol., May 1, 2007; 45(5): 1447 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Peng, C. Trimble, L. Wu, D. Pardoll, R. Roden, C.-F. Hung, and T.-C. Wu HLA-DQB1*02-Restricted HPV-16 E7 Peptide-Specific CD4+ T-Cell Immune Responses Correlate with Regression of HPV-16-Associated High-Grade Squamous Intraepithelial Lesions Clin. Cancer Res., April 15, 2007; 13(8): 2479 - 2487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, M. Sadorra, F. A.R. Garcia, A. P. Cullen, A. T. Lorincz, A. L. Mitchell, D. Whitby, R. Chuke, and J. R. Kornegay Mouthwash as a Low-Cost and Safe Specimen Transport Medium for Human Papillomavirus DNA Testing of Cervicovaginal Specimens Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 840 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Van de Velde, M. Brisson, and M.-C. Boily Modeling Human Papillomavirus Vaccine Effectiveness: Quantifying the Impact of Parameter Uncertainty Am. J. Epidemiol., April 1, 2007; 165(7): 762 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ryding, L. Dahlberg, M. Wallen-Ohman, and J. Dillner Deletion of a major neutralizing epitope of human papillomavirus type 16 virus-like particles J. Gen. Virol., March 1, 2007; 88(3): 792 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Naucler, H.-C. Chen, K. Persson, S.-L. You, C.-Y. Hsieh, C.-A. Sun, J. Dillner, and C.-J. Chen Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case-control study J. Gen. Virol., March 1, 2007; 88(3): 814 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Saslow, P. E. Castle, J. T. Cox, D. D. Davey, M. H. Einstein, D. G. Ferris, S. J. Goldie, D. M. Harper, W. Kinney, A.-B. Moscicki, et al. American Cancer Society Guideline for Human Papillomavirus (HPV) Vaccine Use to Prevent Cervical Cancer and Its Precursors CA Cancer J Clin, January 1, 2007; 57(1): 7 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Piersma, E. S. Jordanova, M. I.E. van Poelgeest, K. M.C. Kwappenberg, J. M. van der Hulst, J. W. Drijfhout, C. J.M. Melief, G. G. Kenter, G. J. Fleuren, R. Offringa, et al. High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer Cancer Res., January 1, 2007; 67(1): 354 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Kovacic, P. E. Castle, R. Herrero, M. Schiffman, M. E. Sherman, S. Wacholder, A. C. Rodriguez, M. L. Hutchinson, M. C. Bratti, A. Hildesheim, et al. Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality. Cancer Res., October 15, 2006; 66(20): 10112 - 10119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Matthews, N. Berrios, J. S. Darnell, and E. Calhoun A Qualitative Evaluation of a Faith-Based Breast and Cervical Cancer Screening Intervention for African American Women Health Educ Behav, October 1, 2006; 33(5): 643 - 663. [Abstract] [PDF]
|
|
|
|
 |
|
 G. M Leung, P. P S Woo, S. M McGhee, A. N Y Cheung, S. Fan, O. Mang, T. Q Thach, and H. Y S Ngan Age-period-cohort analysis of cervical cancer incidence in Hong Kong from 1972 to 2001 using maximum likelihood and Bayesian methods. J Epidemiol Community Health, August 1, 2006; 60(8): 712 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Stevens, E. Rudland, S. M. Garland, and S. N. Tabrizi Assessment of MagNA Pure LC Extraction System for Detection of Human Papillomavirus (HPV) DNA in PreservCyt Samples by the Roche AMPLICOR and LINEAR ARRAY HPV Tests. J. Clin. Microbiol., July 1, 2006; 44(7): 2428 - 2433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Berkhof, N. W.J. Bulkmans, M. C.G. Bleeker, S. Bulk, P. J.F. Snijders, F. J. Voorhorst, and C. J.L.M. Meijer Human papillomavirus type-specific 18-month risk of high-grade cervical intraepithelial neoplasia in women with a normal or borderline/mildly dyskaryotic smear. Cancer Epidemiol. Biomarkers Prev., July 1, 2006; 15(7): 1268 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Muller, K. J. Sales, A. A. Katz, and H. N. Jabbour Seminal Plasma Promotes the Expression of Tumorigenic and Angiogenic Genes in Cervical Adenocarcinoma Cells via the E-Series Prostanoid 4 Receptor Endocrinology, July 1, 2006; 147(7): 3356 - 3365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Winer, J. P. Hughes, Q. Feng, S. O'Reilly, N. B. Kiviat, K. K. Holmes, and L. A. Koutsky Condom use and the risk of genital human papillomavirus infection in young women. N. Engl. J. Med., June 22, 2006; 354(25): 2645 - 2654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Sandri, P. Lentati, E. Benini, P. Dell'Orto, L. Zorzino, F. M. Carozzi, P. Maisonneuve, R. Passerini, M. Salvatici, C. Casadio, et al. Comparison of the Digene HC2 Assay and the Roche AMPLICOR Human Papillomavirus (HPV) Test for Detection of High-Risk HPV Genotypes in Cervical Samples. J. Clin. Microbiol., June 1, 2006; 44(6): 2141 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, A. Aftab, G. Saint-Jean, and L. Mendez Detection of carcinogenic human papillomavirus in specimens collected with a novel self-sampling device. J. Clin. Microbiol., June 1, 2006; 44(6): 2158 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. James, J. H. Lee, and A. J. Klingelhutz Human Papillomavirus Type 16 E6 Activates NF-{kappa}B, Induces cIAP-2 Expression, and Protects against Apoptosis in a PDZ Binding Motif-Dependent Manner. J. Virol., June 1, 2006; 80(11): 5301 - 5307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mino, T. Hatono, N. Matsumoto, T. Mori, Y. Mineta, Y. Aoyama, and T. Sera Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins. J. Virol., June 1, 2006; 80(11): 5405 - 5412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Wiley, E. Wiesmeier, E. Masongsong, K. H. Gylys, L. A. Koutsky, D. G. Ferris, E. Barr, J. Yu Rao, and The Proof of Principle Study Investigative Group Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 915 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Alam, E. Sen, H. Brashear, and C. Meyers Adeno-Associated Virus Type 2 Increases Proteosome-Dependent Degradation of p21WAF1 in a Human Papillomavirus Type 31b-Positive Cervical Carcinoma Line. J. Virol., May 1, 2006; 80(10): 4927 - 4939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Dempsey, G. D. Zimet, R. L. Davis, and L. Koutsky Factors That Are Associated With Parental Acceptance of Human Papillomavirus Vaccines: A Randomized Intervention Study of Written Information About HPV Pediatrics, May 1, 2006; 117(5): 1486 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S-M A Kulmala, S M Syrjanen, U B Gyllensten, I P Shabalova, N Petrovichev, P Tosi, K J Syrjanen, and B C Johansson Early integration of high copy HPV16 detectable in women with normal and low grade cervical cytology and histology J. Clin. Pathol., May 1, 2006; 59(5): 513 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kraus, T. Molden, R. Holm, A. K. Lie, F. Karlsen, G. B. Kristensen, and H. Skomedal Presence of E6 and E7 mRNA from Human Papillomavirus Types 16, 18, 31, 33, and 45 in the Majority of Cervical Carcinomas J. Clin. Microbiol., April 1, 2006; 44(4): 1310 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ortiz, M. Torres, L. Munoz, E. Fernandez-Garcia, J. Canals, A. I. Cabornero, E. Aguilar, J. Ballesteros, J. del Amo, and A. Garcia-Saiz Oncogenic Human Papillomavirus (HPV) Type Distribution and HPV Type 16 E6 Variants in Two Spanish Population Groups with Different Levels of HPV Infection Risk J. Clin. Microbiol., April 1, 2006; 44(4): 1428 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wu, L. Meng, S. Wang, W. Wang, L. Xi, X. Tian, G. Chen, Y. Wu, J. Zhou, G. Xu, et al. Reversal of the malignant phenotype of cervical cancer CaSki cells through adeno-associated virus-mediated delivery of HPV16 E7 antisense RNA. Clin. Cancer Res., April 1, 2006; 12(7 Pt 1): 2032 - 2037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Pett, M. T. Herdman, R. D. Palmer, G. S. H. Yeo, M. K. Shivji, M. A. Stanley, and N. Coleman Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response PNAS, March 7, 2006; 103(10): 3822 - 3827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Castellsague, M. Diaz, S. de Sanjose, N. Munoz, R. Herrero, S. Franceschi, R. W. Peeling, R. Ashley, J. S. Smith, P. J. F. Snijders, et al. Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. J Natl Cancer Inst, March 1, 2006; 98(5): 303 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Ferris Vaccines for Preventing HPV-Related Anogenital Infection and Neoplasia J Am Osteopath Assoc, March 1, 2006; 106(suppl_1): S9 - S13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Hawes, C. W. Critchlow, P. S. Sow, P. Toure, I. N'Doye, A. Diop, J. M. Kuypers, A. A. Kasse, and N. B. Kiviat Incident High-Grade Squamous Intraepithelial Lesions in Senegalese Women With and Without Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 J Natl Cancer Inst, January 18, 2006; 98(2): 100 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, J. Jeronimo, M. Schiffman, R. Herrero, A. C. Rodriguez, M. C. Bratti, A. Hildesheim, S. Wacholder, L. R. Long, L. Neve, et al. Age-Related Changes of the Cervix Influence Human Papillomavirus Type Distribution Cancer Res., January 15, 2006; 66(2): 1218 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, A. Clements, K. Zhao, and R. Marmorstein Structure of the Human Papillomavirus E7 Oncoprotein and Its Mechanism for Inactivation of the Retinoblastoma Tumor Suppressor J. Biol. Chem., January 6, 2006; 281(1): 578 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Aires, A. M. Cianciarullo, S. M. Carneiro, L. L. Villa, E. Boccardo, G. Perez-Martinez, I. Perez-Arellano, M. L. S. Oliveira, and P. L. Ho Production of Human Papillomavirus Type 16 L1 Virus-Like Particles by Recombinant Lactobacillus casei Cells Appl. Envir. Microbiol., January 1, 2006; 72(1): 745 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Feng and N. B. Kiviat New and Surprising Insights Into Pathogenesis of Multicentric Squamous Cancers in the Female Lower Genital Tract J Natl Cancer Inst, December 21, 2005; 97(24): 1798 - 1799. [Full Text] [PDF]
|
|
|
|
|
|
A. Behren, C. Simon, R. M. Schwab, E. Loetzsch, S. Brodbeck, E. Huber, F. Stubenrauch, H. P. Zenner, and T. Iftner Papillomavirus E2 Protein Induces Expression of the Matrix Metalloproteinase-9 via the Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Pathway Cancer Res., December 15, 2005; 65(24): 11613 - 11621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Schlecht, R. D. Burk, J. M. Palefsky, H. Minkoff, X. Xue, L. S. Massad, M. Bacon, A. M. Levine, K. Anastos, S. J. Gange, et al. Variants of human papillomaviruses 16 and 18 and their natural history in human immunodeficiency virus-positive women J. Gen. Virol., October 1, 2005; 86(10): 2709 - 2720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Bravaccini, M A Sanchini, A Amadori, L Medri, L Saragoni, D Calistri, F Monti, A Volpi, and D Amadori Potential of telomerase expression and activity in cervical specimens as a diagnostic tool J. Clin. Pathol., September 1, 2005; 58(9): 911 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Dias, J. Van Doren, S. Schlottmann, S. Kelly, D. Puchalski, W. Ruiz, P. Boerckel, J. Kessler, J. M. Antonello, T. Green, et al. Optimization and Validation of a Multiplexed Luminex Assay To Quantify Antibodies to Neutralizing Epitopes on Human Papillomaviruses 6, 11, 16, and 18 Clin. Vaccine Immunol., August 1, 2005; 12(8): 959 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Simoes, M. A. G. Goncalves, E. A. Donadi, A. L. Simoes, J. S. R. Bettini, G. Duarte, S. M. Quintana, M. W. P. Carvalho, and E. G. Soares Association of Tumor Necrosis Factor a-2 and a-8 Microsatellite Alleles with Human Papillomavirus and Squamous Intraepithelial Lesions among Women in Brazil J. Clin. Microbiol., August 1, 2005; 43(8): 3932 - 3937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, D. Solomon, M. Schiffman, C. M. Wheeler, and for the ALTS Group Human Papillomavirus Type 16 Infections and 2-Year Absolute Risk of Cervical Precancer in Women With Equivocal or Mild Cytologic Abnormalities J Natl Cancer Inst, July 20, 2005; 97(14): 1066 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Khan, P. E. Castle, A. T. Lorincz, S. Wacholder, M. Sherman, D. R. Scott, B. B. Rush, A. G. Glass, and M. Schiffman The Elevated 10-Year Risk of Cervical Precancer and Cancer in Women With Human Papillomavirus (HPV) Type 16 or 18 and the Possible Utility of Type-Specific HPV Testing in Clinical Practice J Natl Cancer Inst, July 20, 2005; 97(14): 1072 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soderlund-Strand, P. Rymark, P. Andersson, J. Dillner, and L. Dillner Comparison between the Hybrid Capture II Test and a PCR-Based Human Papillomavirus Detection Method for Diagnosis and Posttreatment Follow-Up of Cervical Intraepithelial Neoplasia J. Clin. Microbiol., July 1, 2005; 43(7): 3260 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. P. C. van Ham, J. M. J. E. Bakkers, G. K. Harbers, W. G. V. Quint, L. F. A. G. Massuger, and W. J. G. Melchers Comparison of Two Commercial Assays for Detection of Human Papillomavirus (HPV) in Cervical Scrape Specimens: Validation of the Roche AMPLICOR HPV Test as a Means To Screen for HPV Genotypes Associated with a Higher Risk of Cervical Disorders J. Clin. Microbiol., June 1, 2005; 43(6): 2662 - 2667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Chen, M. Terai, L. Fu, R. Herrero, R. DeSalle, and R. D. Burk Diversifying Selection in Human Papillomavirus Type 16 Lineages Based on Complete Genome Analyses J. Virol., June 1, 2005; 79(11): 7014 - 7023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Lack, B West, D Jeffries, G Ekpo, L Morison, W P Soutter, G Walraven, and L Boryseiwicz Comparison of non-invasive sampling methods for detection of HPV in rural African women Sex Transm Inf, June 1, 2005; 81(3): 239 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Leyden, M. M. Manos, A. M. Geiger, S. Weinmann, J. Mouchawar, K. Bischoff, M. U. Yood, J. Gilbert, and S. H. Taplin Cervical Cancer in Women With Comprehensive Health Care Access: Attributable Factors in the Screening Process J Natl Cancer Inst, May 4, 2005; 97(9): 675 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Richardson, M. Abrahamowicz, P.-P. Tellier, G. Kelsall, R. du Berger, A. Ferenczy, F. Coutlee, and E. L. Franco Modifiable Risk Factors Associated with Clearance of Type-Specific Cervical Human Papillomavirus Infections in a Cohort of University Students Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1149 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McIntyre-Seltman, P. E. Castle, R. Guido, M. Schiffman, C. M. Wheeler, and for The ALTS Group Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA-Positive Women with Equivocal or Mildly Abnormal Cytology Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1165 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Castle, M. Schiffman, D. R. Scott, M. E. Sherman, A. G. Glass, B. B. Rush, J. E. Schussler, S. Wacholder, and A. T. Lorincz Semiquantitative Human Papillomavirus Type 16 Viral Load and the Prospective Risk of Cervical Precancer and Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1311 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gharizadeh, M. Oggionni, B. Zheng, E. Akom, N. Pourmand, A. Ahmadian, K.-L. Wallin, and P. Nyren Type-Specific Multiple Sequencing Primers: A Novel Strategy for Reliable and Rapid Genotyping of Human Papillomaviruses by Pyrosequencing Technology J. Mol. Diagn., May 1, 2005; 7(2): 198 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Poland, R. M. Jacobson, L. A. Koutsky, G. M. Tamms, R. Railkar, J. F. Smith, J. T. Bryan, P. F. Cavanaugh Jr, K. U. Jansen, and E. Barr Immunogenicity and Reactogenicity of a Novel Vaccine for Human Papillomavirus 16: A 2-Year Randomized Controlled Clinical Trial Mayo Clin. Proc., May 1, 2005; 80(5): 601 - 610. [Abstract] [PDF]
|
|
|
|
|
|
H. D. Strickler, R. D. Burk, M. Fazzari, K. Anastos, H. Minkoff, L. S. Massad, C. Hall, M. Bacon, A. M. Levine, D. H. Watts, et al. Natural History and Possible Reactivation of Human Papillomavirus in Human Immunodeficiency Virus-Positive Women J Natl Cancer Inst, April 20, 2005; 97(8): 577 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tsezou, P. Oikonomou, P. Kollia, I. Mademtzis, E. Kostopoulou, I. Messinis, and N. Vamvakopoulos The Role of Human Telomerase Catalytic Subunit mRNA Expression in Cervical Dysplasias Experimental Biology and Medicine, April 1, 2005; 230(4): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Daniel, C. Chiu, E. Giraudo, M. Inoue, L. A. Mizzen, N. R. Chu, and D. Hanahan CD4+ T Cell-Mediated Antigen-Specific Immunotherapy in a Mouse Model of Cervical Cancer Cancer Res., March 1, 2005; 65(5): 2018 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Feng, A. Balasubramanian, S. E. Hawes, P. Toure, P. S. Sow, A. Dem, B. Dembele, C. W. Critchlow, L. Xi, H. Lu, et al. Detection of Hypermethylated Genes in Women with and Without Cervical Neoplasia J Natl Cancer Inst, February 16, 2005; 97(4): 273 - 282. [Abstract] [Full Text] [PDF]
|
|