© 1991 by Oxford University Press
Journal of the National Cancer Institute, Vol. 83, No. 5, 355-358,
March 6, 1991
© 1991 Oxford University Press
A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer
Slone Epidemilogy Unit, School of Public Health, Boston University School of Medicine Brookline, Mass
Department of Epidemilogy and Biostatistics, Memorial Slone-Kettering Cancer Center New York, NY.
Cancer Care and Research Program, New York Hospital, Department of Public health, Cornell Medical Center NY.
Department of medicine, Section of General Medicine, Clinical Epidemiology Unit, The University of Pennsylvannia School of Medicine Philadelphia, Pa.
*Correspondence to: Lynn Rosenberg, ScD, Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, 1371 Beacon St, Brookline, MA 02146.
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and tumor growth in the rodent colon. We assessed NSAID use in relation to risk of human large-bowel cancer in a hospital-based, case-control study of 1326 patients with colorectal cancer and 4891 control patients. For regular NSAID use that continued into the year before interview, the multivariate relative risk estimate was 0.5 (95% confidence interval, 0.4 to 0.8); the estimate decreased as the duration of use increased, but the trend was not statistically significant. Similar results were obtained whether cancer or non-cancer controls were used, and the inverse association was apparent for both colon cancer and rectal cancer in men and women and in subjects younger and older than 60 years. Regular NSAID use that had been discontinued at least 1 year previously and non-regular use were not associated with risk. Almost all regular NSAID use was of aspirin-containing drugs. The present data suggest that the sustained use of NSAIDs reduces the incidence of human large-bowel cancer. [J Natl Cancer Inst 83:355–358, 1991]
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Kune Commentary: Aspirin and cancer prevention Int. J. Epidemiol., October 5, 2007; (2007) dym194v1. [Full Text] [PDF]
|
|
|
|
|
|
R. Logan Commentary: Preventing colorectal cancer with aspirin what next? Int. J. Epidemiol., October 5, 2007; (2007) dym204v1. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jewett, C. Head, and N.A. Cacalano Emerging Mechanisms of Immunosuppression in Oral Cancers Journal of Dental Research, December 1, 2006; 85(12): 1061 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Hayes, K. E. Anderson, and A. R. Folsom Association between Nonsteroidal Anti-inflammatory Drug Use and the Incidence of Lung Cancer in the Iowa Women's Health Study. Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2226 - 2231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mahipal, K. E. Anderson, P. J. Limburg, and A. R. Folsom Nonsteroidal Anti-inflammatory Drugs and Subsite-Specific Colorectal Cancer Incidence in the Iowa Women's Health Study. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1785 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Allison, C. Garland, R. Chlebowski, M. Criqui, R. Langer, L. Wu, H. Roy, A. McTiernan, L. Kuller, and for the Women's Health Initiative Investigators The Association between Aspirin Use and the Incidence of Colorectal Cancer in Women Am. J. Epidemiol., September 15, 2006; 164(6): 567 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Chia, P. A. Newcomb, J. Bigler, L. M. Morimoto, S. N. Thibodeau, and J. D. Potter Risk of Microsatellite-Unstable Colorectal Cancer Is Associated Jointly with Smoking and Nonsteroidal Anti-inflammatory Drug Use. Cancer Res., July 1, 2006; 66(13): 6877 - 6883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Xiao, A. Deguchi, G. G. Gundersen, B. Oehlen, L. Arnold, and I. B. Weinstein The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization Mol. Cancer Ther., January 1, 2006; 5(1): 60 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Sansbury, R. C. Millikan, J. C. Schroeder, P. G. Moorman, K. E. North, and R. S. Sandler Use of Nonsteroidal Antiinflammatory Drugs and Risk of Colon Cancer in a Population-based, Case-Control Study of African Americans and Whites Am. J. Epidemiol., September 15, 2005; 162(6): 548 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Chan, E. L. Giovannucci, J. A. Meyerhardt, E. S. Schernhammer, G. C. Curhan, and C. S. Fuchs Long-term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs and Risk of Colorectal Cancer JAMA, August 24, 2005; 294(8): 914 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Brown and R. N. DuBois COX-2: A Molecular Target for Colorectal Cancer Prevention J. Clin. Oncol., April 20, 2005; 23(12): 2840 - 2855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lindblad, J. Lagergren, and L. A. Garcia Rodriguez Nonsteroidal Anti-inflammatory Drugs and Risk of Esophageal and Gastric Cancer Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 444 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Soumaoro, H. Uetake, T. Higuchi, Y. Takagi, M. Enomoto, and K. Sugihara Cyclooxygenase-2 Expression: A Significant Prognostic Indicator for Patients With Colorectal Cancer Clin. Cancer Res., December 15, 2004; 10(24): 8465 - 8471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Sivak-Sears, J. A. Schwartzbaum, R. Miike, M. Moghadassi, and M. Wrensch Case-Control Study of Use of Nonsteroidal Antiinflammatory Drugs and Glioblastoma Multiforme Am. J. Epidemiol., June 15, 2004; 159(12): 1131 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Chan, E. L. Giovannucci, E. S. Schernhammer, G. A. Colditz, D. J. Hunter, W. C. Willett, and C. S. Fuchs A Prospective Study of Aspirin Use and the Risk for Colorectal Adenoma Ann Intern Med, February 3, 2004; 140(3): 157 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Lieberman, S. Prindiville, D. G. Weiss, and W. Willett Risk Factors for Advanced Colonic Neoplasia and Hyperplastic Polyps in Asymptomatic Individuals JAMA, December 10, 2003; 290(22): 2959 - 2967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Wang, J. Q. Huang, G. F. Zheng, S. K. Lam, J. Karlberg, and B. C.-Y. Wong Non-steroidal Anti-inflammatory Drug Use and the Risk of Gastric Cancer: A Systematic Review and Meta-analysis J Natl Cancer Inst, December 3, 2003; 95(23): 1784 - 1791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Herendeen and C. Lindley Use of NSAIDs for the Chemoprevention of Colorectal Cancer Ann. Pharmacother., November 1, 2003; 37(11): 1664 - 1674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Higuchi, T. Iwama, K. Yoshinaga, M. Toyooka, M. M. Taketo, and K. Sugihara A Randomized, Double-Blind, Placebo-Controlled Trial of the Effects of Rofecoxib, a Selective Cyclooxygenase-2 Inhibitor, on Rectal Polyps in Familial Adenomatous Polyposis Patients Clin. Cancer Res., October 15, 2003; 9(13): 4756 - 4760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Sandler, S. Halabi, J. A. Baron, S. Budinger, E. Paskett, R. Keresztes, N. Petrelli, J. M. Pipas, D. D. Karp, C. L. Loprinzi, et al. A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer N. Engl. J. Med., March 6, 2003; 348(10): 883 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Boyle and M. E. Leon Epidemiology of colorectal cancer Br. Med. Bull., December 1, 2002; 64(1): 1 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Bair III, N. Hart, J. Einspahr, G. Liu, Z. Dong, D. Alberts, and G. T. Bowden Inhibitory Effects of Sodium Salicylate and Acetylsalicylic Acid on UVB-induced Mouse Skin Carcinogenesis Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1645 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Vaughan, A. R. Kristal, P. L. Blount, D. S. Levine, P. C. Galipeau, L. J. Prevo, C. A. Sanchez, P. S. Rabinovitch, and B. J. Reid Nonsteroidal Anti-inflammatory Drug Use, Body Mass Index, and Anthropometry in Relation to Genetic and Flow Cytometric Abnormalities in Barrett's Esophagus Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 745 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Sunayama, H. Konno, T. Nakamura, H. Kashiwabara, T. Shoji, T. Tsuneyoshi, and S. Nakamura The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC{Delta}474 knockout mice Carcinogenesis, August 1, 2002; 23(8): 1351 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Munkarah, R. Morris, P. Baumann, G. Deppe, J. Malone, M. P. Diamond, and G. M. Saed Effects of Prostaglandin E2 on Proliferation and Apoptosis of Epithelial Ovarian Cancer Cells Reproductive Sciences, May 1, 2002; 9(3): 168 - 173. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Davies, L.-A. Martin, N. Sacks, and M. Dowsett Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention Ann. Onc., May 1, 2002; 13(5): 669 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Half, X. M. Tang, K. Gwyn, A. Sahin, K. Wathen, and F. A. Sinicrope Cyclooxygenase-2 Expression in Human Breast Cancers and Adjacent Ductal Carcinoma in Situ Cancer Res., March 1, 2002; 62(6): 1676 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O. Roberts, D. J. Jacobson, C. J. Girman, T. Rhodes, M. M. Lieber, and S. J. Jacobsen A Population-Based Study of Daily Nonsteroidal Anti-inflammatory Drug Use and Prostate Cancer Mayo Clin. Proc., March 1, 2002; 77(3): 219 - 225. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Thun, S. J. Henley, and C. Patrono Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues J Natl Cancer Inst, February 20, 2002; 94(4): 252 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Ladabaum, C. L. Chopra, G. Huang, J. M. Scheiman, M. E. Chernew, and A. M. Fendrick Aspirin as an Adjunct to Screening for Prevention of Sporadic Colorectal Cancer: A Cost-Effectiveness Analysis Ann Intern Med, November 6, 2001; 135(9): 769 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J A Eaden, K R Abrams, and J F Mayberry The risk of colorectal cancer in ulcerative colitis: a meta-analysis Gut, April 1, 2001; 48(4): 526 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Boudreau, K. H. Sohn, S. H. Rhee, S. W. Lee, J. D. Hunt, and D. H. Hwang Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-independent Pathways Cancer Res., February 1, 2001; 61(4): 1386 - 1391. [Abstract] [Full Text]
|
|
|
|
|
|
M. T. Taylor, K. R. Lawson, N. A. Ignatenko, S. E. Marek, D. E. Stringer, B. A. Skovan, and E. W. Gerner Sulindac Sulfone Inhibits K-ras-dependent Cyclooxygenase-2 Expression in Human Colon Cancer Cells Cancer Res., December 1, 2000; 60(23): 6607 - 6610. [Abstract] [Full Text]
|
|
|
|
|
|
L. Rosenberg, J. R. Palmer, R. S. Rao, P. F. Coogan, B. L. Strom, A. G. Zauber, P. D. Stolley, and S. Shapiro A Case-Control Study of Analgesic Use and Ovarian Cancer Cancer Epidemiol. Biomarkers Prev., September 1, 2000; 9(9): 933 - 937. [Abstract] [Full Text]
|
|
|
|
|
|
G. Steinbach, P. M. Lynch, R. K.S. Phillips, M. H. Wallace, E. Hawk, G. B. Gordon, N. Wakabayashi, B. Saunders, Y. Shen, T. Fujimura, et al. The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis N. Engl. J. Med., June 29, 2000; 342(26): 1946 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Janne and R. J. Mayer Chemoprevention of Colorectal Cancer N. Engl. J. Med., June 29, 2000; 342(26): 1960 - 1968. [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Plastaras, F. P. Guengerich, D. W. Nebert, and L. J. Marnett Xenobiotic-metabolizing Cytochromes P450 Convert Prostaglandin Endoperoxide to Hydroxyheptadecatrienoic Acid and the Mutagen, Malondialdehyde J. Biol. Chem., April 14, 2000; 275(16): 11784 - 11790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H-H. S. Chow, D. L. Earnest, D. Clark, N. Mason-Liddil, C. B. Kramer, J. G. Einspahr, J. M. Guillen-Rodriguez, D. J. Roe, W. Malone, J. A. Crowell, et al. Effect of Subacute Ibuprofen Dosing on Rectal Mucosal Prostaglandin E2 Levels in Healthy Subjects with a History of Resected Polyps Cancer Epidemiol. Biomarkers Prev., April 1, 2000; 9(4): 351 - 356. [Abstract] [Full Text]
|
|
|
|
|
|
B. S. Reddy Novel Approaches to the Prevention of Colon Cancer by Nutritional Manipulation and Chemoprevention Cancer Epidemiol. Biomarkers Prev., March 1, 2000; 9(3): 239 - 247. [Abstract] [Full Text]
|
|
|
|
|
|
H. Y. Lim, H. J. Joo, J. H. Choi, J. W. Yi, M. S. Yang, D. Y. Cho, H. S. Kim, D. K. Nam, K. B. Lee, and H. C. Kim Increased Expression of Cyclooxygenase-2 Protein in Human Gastric Carcinoma Clin. Cancer Res., February 1, 2000; 6(2): 519 - 525. [Abstract] [Full Text]
|
|
|
|
|
|
P. F. Coogan, L. Rosenberg, J. R. Palmer, B. L. Strom, A. G. Zauber, P. D. Stolley, and S. Shapiro Nonsteroidal Anti-Inflammatory Drugs and Risk of Digestive Cancers at Sites Other Than the Large Bowel Cancer Epidemiol. Biomarkers Prev., January 1, 2000; 9(1): 119 - 123. [Abstract] [Full Text]
|
|
|
|
|
|
R. van Stolk, G. Stoner, W. L. Hayton, K. Chan, B. DeYoung, L. Kresty, B. H. Kemmenoe, P. Elson, L. Rybicki, J. Church, et al. Phase I Trial of Exisulind (Sulindac Sulfone, FGN-1) as a Chemopreventive Agent in Patients with Familial Adenomatous Polyposis Clin. Cancer Res., January 1, 2000; 6(1): 78 - 89. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Yamamoto, M.-J. Yin, K.-M. Lin, and R. B. Gaynor Sulindac Inhibits Activation of the NF-kappa B Pathway J. Biol. Chem., September 17, 1999; 274(38): 27307 - 27314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. P. Li and A. S. Whittemore Genetically Tailored Preventive Strategies: an Effective Plan for the Twenty-first Century? Cancer Epidemiol. Biomarkers Prev., August 1, 1999; 8(8): 649 - 658. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Potter Colorectal Cancer: Molecules and Populations J Natl Cancer Inst, June 2, 1999; 91(11): 916 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Achiwa, Y. Yatabe, T. Hida, T. Kuroishi, K.-i. Kozaki, S. Nakamura, M. Ogawa, T. Sugiura, T. Mitsudomi, and T. Takahashir Prognostic Significance of Elevated Cyclooxygenase 2 Expression in Primary, Resected Lung Adenocarcinomas Clin. Cancer Res., May 1, 1999; 5(5): 1001 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, H. A.J. Schut, P. Conran, P. M. Kramer, R. A. Lubet, V. E. Steele, E. E. Hawk, G. J. Kelloff, and M. A. Pereira Prevention by aspirin and its combination with {alpha}-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon Carcinogenesis, March 1, 1999; 20(3): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Smalley, W. A. Ray, J. Daugherty, and M. R. Griffin Use of Nonsteroidal Anti-inflammatory Drugs and Incidence of Colorectal Cancer: A Population-Based Study Arch Intern Med, January 25, 1999; 159(2): 161 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hejna, M. Raderer, and C. C. Zielinski Inhibition of Metastases by Anticoagulants J Natl Cancer Inst, January 6, 1999; 91(1): 22 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kim and S. M. Fischer Transcriptional Regulation of Cyclooxygenase-2 in Mouse Skin Carcinoma Cells. REGULATORY ROLE OF CCAAT/ENHANCER-BINDING PROTEINS IN THE DIFFERENTIAL EXPRESSION OF CYCLOOXYGENASE-2 IN NORMAL AND NEOPLASTIC TISSUES J. Biol. Chem., October 16, 1998; 273(42): 27686 - 27694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M LANGMAN and P BOYLE Chemoprevention of colorectal cancer Gut, October 1, 1998; 43(4): 578 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Proceedings of the British Toxicology Society Annual Congress University of Surrey, Guildford 19 - 22 April 1998 Human and Experimental Toxicology, September 1, 1998; 17(9): 469 - 534. [PDF]
|
|
|
|
 |
|
 B. Bellosillo, M. Pique, M. Barragan, E. Castano, N. Villamor, D. Colomer, E. Montserrat, G. Pons, and J. Gil Aspirin and Salicylate Induce Apoptosis and Activation of Caspases in B-Cell Chronic Lymphocytic Leukemia Cells Blood, August 15, 1998; 92(4): 1406 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sawaoka, S. Kawano, S. Tsuji, M. Tsujii, E. S. Gunawan, Y. Takei, K. Nagano, and M. Hori Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice Am J Physiol Gastrointest Liver Physiol, June 1, 1998; 274(6): G1061 - G1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R M Harris, R J Hawker, M J S Langman, S Singh, and R H Waring Inhibition of phenolsulphotransferase by salicylic acid: a possible mechanism by which aspirin may reduce carcinogenesis Gut, February 1, 1998; 42(2): 272 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Martinez, T. Sanchez, and J. J. Moreno Role of prostaglandin H synthase-2-mediated conversion of arachidonic acid in controlling 3T6 fibroblast growth Am J Physiol Cell Physiol, November 1, 1997; 273(5): C1466 - C1471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, W.-Y. Ma, D. Hanenberger, M. P. Cleary, G. T. Bowden, and Z. Dong Inhibition of Ultraviolet B-induced Activator Protein-1 (AP-1) Activity by Aspirin in AP-1-Luciferase Transgenic Mice J. Biol. Chem., October 17, 1997; 272(42): 26325 - 26331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Castaño, M. Dalmau, M. Martí, F. Berrocal, R. Bartrons, and J. Gil Inhibition of DNA Synthesis by Aspirin in Swiss 3T3 Fibroblasts J. Pharmacol. Exp. Ther., January 1, 1997; 280(1): 366 - 372. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Johnson, S. A. Prindiville, G. Morgan, D. F. Roychowdhury, A.A. van Bodegraven, J. Lourens, J.W. Sindram, H. J. Kaufmann, M. Schuler, E. Giovannucci, et al. Aspirin and the Risk of Colorectal Cancer in Women N. Engl. J. Med., January 11, 1996; 334(2): 119 - 122. [Full Text]
|
|
|
|
|
|
E. Giovannucci, K. M. Egan, D. J. Hunter, M. J. Stampfer, G. A. Colditz, W. C. Willett, and F. E. Speizer Aspirin and the Risk of Colorectal Cancer in Women N. Engl. J. Med., September 7, 1995; 333(10): 609 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Waterhouse and D. Brenner Aspirin, NSAIDs, and Risk Reduction of Colorectal Cancer: The Problem Is Translation Arch Intern Med, February 28, 1994; 154(4): 366 - 368. [Abstract] [PDF]
|
|
|
|
|
|
I. I. Peleg, H. T. Maibach, S. H. Brown, and C. M. Wilcox Aspirin and Nonsteroidal Anti-inflammatory Drug Use and the Risk of Subsequent Colorectal Cancer Arch Intern Med, February 28, 1994; 154(4): 394 - 400. [Abstract] [PDF]
|
|