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JNCI Journal of the National Cancer Institute 1991 83(3):170-178; doi:10.1093/jnci/83.3.170
© 1991 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 83, No. 3, 170-178, February 6, 1991
© 1991 Oxford University Press

Stress Response Protein (srp–27) Determination in Primary Human Breast Carcinomas: Clinical, Histologic, and Prognostic Correlations

Ann Thor1,*, Christopher Benz3, Dan Moore, II5, Eric Goldman4, Susan Edgerton1, Jacques Landry6, Laurent Schwartz2, Brian Mayall4, Eileen Hickey7, Lee A. Weber7

1Department of Pathology, Massachusetts General Hospital and Harvard University Mass
2Department of Radiation Medicine, Massachusetts General Hospital and Harvard University Mass
3Department of Medicine, University of California at San Francisco Calif.
4Department of Laboratory Medicine, University of California at san Francisco Calif.
5Division of Biomedical Sciences, Lawrence Livermore National Laboratory Livermore, Calif.
6Laval University Cancer research Center Quebec, PQ, Canada
7L.A. Weber, Department of Biology, University of South Florida Tampa, Fla

*Correspondence to: Ann Thor, MD, Pathology Department, Massachusett General Hospital, Fruit St, Boston, MA 02114

Expression of an estrogen-regulated protein known as the 27000-d heat-shock or stress-response protein(srp-27) was evaluated in human breast carcinomas and established breast cancer cell lines. Results obtained by Northern and Western blot analyses and immunohistochemical methods were concordant. Immunohistochemical assessment of srp-27 expression in 300 breast carcinomas (with median patient follow-up of 8 years) was performed. Twenty-six percent of lymphnode-negative and 45% of lymph node-positive tumors were overexpressors. Univariate analysis demonstrated significant correlations between srp-27 overexpression and estrogen receptor(ER) content, pS2 protein expression, nodal metastases, advanced T stage, lymphatic/vascular invasion, and a shorter disease-free survival period (but not a shorter overall survival) for the study population as a whole. Regression tree analysis showed that srp-27 expression was an independent prognostic indicator for disease-free survival only in patients with one to three positive lymph nodes. The Cox proportional hazards model confirmed the independent prognostic significance of nodal involvement, T stage, and ER content but failed to recognize srp-27 overexpression as a significant independent parameter predictive of patient outcome in the patient population as a whole. The observed associations between srp-27 overexpression and more aggressive tumors suggest a biologic role for srp-27 in human breast carcinomas. [J Natl Cancer Inst 83:170–178, 1991]


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