Skip Navigation

JNCI Journal of the National Cancer Institute 1991 83(20):1491-1495; doi:10.1093/jnci/83.20.1491
© 1991 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Rose, D. P.
Right arrow Articles by Meschter, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rose, D. P.
Right arrow Articles by Meschter, C. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 83, No. 20, 1491-1495, October 16, 1991
© 1991 Oxford University Press

Effect of Dietary Fat on Human Breast Cancer Growth and Lung Metastasis in Nude Mice

David P. Rose*, Jeanne M. Connolly, Carol L. Meschter

American Health Foundation Valhalla, N.Y.

*Correspondence to: David P. Rose, M.D., Ph.D., Division of Nutrition and Endocrinology, American Health Foundation, Dana Rd., Valhalla, NY 10595.

Results from epidemiological studies have generally indicated an association of dietary saturated animal fats with human breast cancer risk. Some studies, however, have suggested a similar association for some polyunsaturated vegetable fats shown to promote both rodent mammary carcinogenesis and metastasis. This study was performed to evaluate the effects of corn oil on growth and metastasis of MDA-MB-435 human breast cancer cells, which have a propensity for metastasis. Corn oil is rich in the omega-6 fatty acid linoleic acid. Fiftyeight female athymic nude mice (NCr-nu/nu) were fed a high-fat diet (23% wt/wt corn oil; 12% linoleic acid) or a low-fat diet (5% wt/wt corn oil; 2.7% linoleic acid). Seven days after diets were started, tumor cells (1 x 106) were injected into a mammary fat pad. The time to appearance of solid tumors and the tumor size were recorded. After 15 weeks, the study was terminated, and autopsies were performed to determine the weight of the primary tumor and the extent of metastasis. The latent interval for tumor appearance in the animals fed the high-fat diet was shorter than that in the low-fat diet group, and the tumor growth rate in the high-fat diet group showed a small but statistically significant increase compared with the low-fat diet group. Primary tumors developed in 27 of the 29 mice on the high-fat diet and in 21 of the 29 on the low-fat diet. Of the mice with palpable primary tumors, 18 of 27 in the high-fat diet group and eight of 21 in the low-fat diet group had macroscopic lung metastases. The extent of metastasis in the high-fat diet group was independent of the primary tumor weight, but only those in the low-fat diet group with primary tumors weighing more than 2 g developed metastases. These results suggest that a high-fat diet rich in omega-6 polyunsaturated fatty acid can enhance metastasis of human breast cancer cells in this mouse model. The findings support the need for further study of the relationship between dietary polyunsaturated fats and breast cancer risk and for experiments to determine the effect on metastasis of only a 50% difference in fat intake— the dietary goal of the proposed clinical trials of low-fat dietary intervention in breast cancer patients. [J Natl Cancer Inst 83: 1491–1495, 1991]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Prevention ResearchHome page
S. E. Olivo-Marston, Y. Zhu, R. Y. Lee, A. Cabanes, G. Khan, A. Zwart, Y. Wang, R. Clarke, and L. Hilakivi-Clarke
Gene Signaling Pathways Mediating the Opposite Effects of Prepubertal Low-Fat and High-Fat n-3 Polyunsaturated Fatty Acid Diets on Mammary Cancer Risk
Cancer Prevention Research, December 1, 2008; 1(7): 532 - 545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. E. Duncan, A. El-Sohemy, and M. C. Archer
Mevalonate Promotes the Growth of Tumors Derived from Human Cancer Cells in Vivo and Stimulates Proliferation in Vitro with Enhanced Cyclin-dependent Kinase-2 Activity
J. Biol. Chem., August 6, 2004; 279(32): 33079 - 33084.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. C Larsson, M. Kumlin, M. Ingelman-Sundberg, and A. Wolk
Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms
Am. J. Clinical Nutrition, June 1, 2004; 79(6): 935 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. W. Istfan, Z.-Y. Chen, and S. Rex
Fish oil slows S phase progression and may cause upstream shift of DHFR replication origin ori-beta in CHO cells
Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1009 - C1024.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Nixon
Alternative and Complementary Therapies in Oncology Care
J. Clin. Oncol., November 1, 1999; 17(90001): 35 - 37.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.