Skip Navigation

JNCI Journal of the National Cancer Institute 1991 83(17):1226-1231; doi:10.1093/jnci/83.17.1226
© 1991 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Hayes, H. M.
Right arrow Articles by Richardson, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayes, H. M.
Right arrow Articles by Richardson, R. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 83, No. 17, 1226-1231, September 4, 1991
© 1991 Oxford University Press

Case-Control Study of Canine Malignant Lymphoma: Positive Association With Dog Owner's Use of 2, 4-Dichlorophenoxyacetic Acid Herbicides

Howard M. Hayes*,1, Robert E. Tarone1, Kenneth P. Cantor1, Carl R. Jessen2, Dennis M. McCurnin3, Ralph C. Richardson4

1Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute Bethesda, Md.
2College of Veternary Medicine, University of Minnesota St. Paul
3Veterinary Teaching Hospital, College of Veterinary Medicine, Colorado State University Ft. Collins
4Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University West Lafayette, Ind.

*Correspondence to: H. M. Hayes, D.V.M., Environmental Epidemiology Branch, National Institutes of Health, Executive Plaza North, Rm. 443, Bethesda, MD 20892.

A hospital-based case-control study of companion dogs examined the risk of developing canine malignant lymphoma associated with the use of chemicals in and about the home. Information from a self-administered owner questionnaire and/or a telephone interview of about 491 cases, 466 nontumor controls, and 479 tumor controls indicated that owners in households with dogs that developed malignant lymphoma applied 2, 4-dichlorophenoxyacetic acid (2, 4-D) herbicides to their lawn and/or employed commercial lawn care companies to treat their yard significantly more frequently than control owners (odds ratio = 1.3). In addition, the risk of canine malignant lymphoma rose to a twofold excess with four or more yearly owner applications of 2, 4-D. The findings in this study are consistent with occupational studies in humans, which have reported modest associations between agricultural exposure to 2, 4-D and increased risk of non-Hodgkin's lymphoma, the histology and epidemiology of which are similar to those of canine malignant lymphoma. The present study suggests that human health implications of 2, 4-D exposure in the home environment should receive further investigation. [J Natl Cancer Inst 83:1226–1231, 1991]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Vet PatholHome page
C. Fournel-Fleury, F. Ponce, P. Felman, A. Blavier, C. Bonnefont, L. Chabanne, T. Marchal, J. L. Cadore, I. Goy-Thollot, D. Ledieu, et al.
Canine T-cell Lymphomas: A Morphological, Immunological, and Clinical Study of 46 New Cases
Vet. Pathol., January 1, 2002; 39(1): 92 - 109.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
C J Burns, K K Beard, and J B Cartmill
Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945-94: an update
Occup. Environ. Med., January 1, 2001; 58(1): 24 - 30.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
M. D. Edwards, K. A. Pazzi, P. H. Gumerlock, and B. R. Madewell
c-N-ras is Activated Infrequently in Canine Malignant Lymphoma
Toxicol Pathol, April 1, 1993; 21(3): 288 - 291.
[Abstract] [PDF]

Home page
 International Journal of ToxicologyHome page
I. C. Munro, G. L. Carlo, J. C. Orr, K. G. Sund, R. M. Wilson, E. Kennepohl, B. S. Lynch, and M. Jablinske
A Comprehensive, Integrated Review and Evaluation of the Scientific Evidence Relating to the Safety of the Herbicide 2,4-D
International Journal of Toxicology, September 1, 1992; 11(5): 559 - 664.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.