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JNCI Journal of the National Cancer Institute 1991 83(11):769-774; doi:10.1093/jnci/83.11.769
© 1991 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 83, No. 11, 769-774, June 5, 1991
© 1991 Oxford University Press

Enhanced Tumor Growth of Both Primary and Established Human and Murine Tumor Cells in Athymic Mice After Coinjection With Matrigel

Rafael Fridman, Maura C. Kibbey, Leah S. Royce, Mona Zain, Thomas M. Sweeney, Douglas L. Jicha, John R. Yannelli, George R. Martin, Hynda K. Kleinman*

Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health Baltimore, Md.
Surgery Branch, Division of Cancer Treatment, National Cancer Institute), National Institutes of Health Bathesda, Md.
Gerontology Research Center, National Institute on Aging, National Institutes of Health Baltimore, Md.

*Correspondence to: Hynda K. Kleinman. PhD. National Institute of Dental Research, Bldg 30, Rm 407, National Lnstitutes of Health, Bethesda, MD 20892

Previously we found that the reconstituted basement membrane matrix Matrigel, when premixed with human small-cell lung carcinoma cells and injected subcutaneously into athymic mice, permitted tumor growth, whereas cells injected in the absence of Matrigel did not form tumors. In the present study, we examined additional cell types and determined some of the underlying mechanisms involved in the promotion of tumor formation by Matrigel. The tumor cell lines that we studied included transformed mouse Englebreth-Holm-Swarm tumor cells (T-EHS), human submandibular carcinoma A253 cells, mouse melanoma B16F10 cells, human epidermoid carcinoma KB cells, and human primary renal cell carcinoma cells. When coinjected subcutaneously with Matrigel, these cell lines formed rapidly proliferating tumors. Primary biopsy specimens of human colon carcinoma, when dispersed and coinjected with Matrigel, also formed tumors. Only A253, KB, and B16F10 cells formed small tumors in the absence of Matrigel, but a fivefold to tenfold increase in tumor size was observed in the presence of Matrigel. These data demonstrate a useful method for improving the growth of human tumors in athymic mice.


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