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JNCI Journal of the National Cancer Institute 1991 83(1):29-36; doi:10.1093/jnci/83.1.29
© 1991 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 83, No. 1, 29-36, January 2, 1991
© 1991 Oxford University Press

Increased Expression of the Laminin Receptor in Human Colon Cancer

Vittoria Cioce, Vincent Castronovo, Barry M. Shmookler, Spiridione Garbisa, Walter F. Grigioni, Lance A. Liotta, Mark E. Sobel*

Laboratory of Pathology, National Cancer Institute Bethesda, Md
Hospital Center, Washington DC
Institute of Histology, University of Padova Padova, Italy
Institute of Pathology, University of Bologna Bologna, Italy

Correspondence to: Mark E. Sobel, MD, PhD, Laboratary of Pathology, Bldg 10, Rm 2a33,National Institutes of Health, Bethesda, MD 20892.

It has been proposed that among the various cell-surface proteins capable of interacting with laminin, the 67-kd high-affinity laminin receptor plays a crucial role during tumor invasion and metastasis. In this study, the expression of laminin-receptor-precursor messenger RNA (mRNA) and 67-kd protein was analyzed in human colon adenocarcinoma. In 22 of 23 patients with colon cancer, we found a 2-to 23-fold increase in levels of laminin-receptor-precursor mRNA in the cancer tissues compared with those in matched normal adjacent colonic mucosa. In 10 of 11 cases studied, the level of 67-kd laminin receptor, detected by affinity-purified anti-laminin-receptor synthetic peptide antibodies on immuno-blots of matched tumor and normal tissue extracts, was higher in the colon carcinoma tissue. Immunodetection of laminin receptor in tissue sections using anti-laminin-receptor-peptide antibodies confirmed that the increased expression of laminin receptor was specifically associated with the cancer cells. In a series of 72 paraffin sections of colon lesions, we observed a correlation between the expression of the laminin receptor and the Dukes' classification. Our observations indicate that increased expression of laminin-receptor-precursor mRNA is associated with enhanced levels of the 67-kd laminin receptor as well as with the invasive phenotype of colon carcinoma. Detection of this metastasis-associated gene product may be a valuable adjunct in the evaluation of human colon cancer. [J Natl Cancer Inst 83: 29–36, 1991]


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