© 1990 by Oxford University Press
Journal of the National Cancer Institute, Vol. 82, No. 10, 864-868,
May 16, 1990
© 1990 Oxford University Press
Serum Selenium and Subsequent Risk of Cancer Among Finnish Men and Women
Social Insurance Institution Helsinki and Turku, Finaland
National Public Health Institute Helsinki, Finland
Department of Biomedical Sciences Tampere, Finland
Department of Public Health, University of Tampere Tampere, Finland
Finnish Cancer Registry Helsinki, Finland
Nuffield Department of Clinical Medicine, Oxford University Oxford, England
*Correspondence to: Paul Knekt, Dr. P.H., Research Institute for Social Security, Social Insurance Institution, P.O. Box 78, SF-00381 Helsinki, Finland.
The association between the serum selenium level and the subsequent incidence of cancer was investigated in a longitudinal study of 39, 268 men and women participating in the Social Insurance Institution's Mobile Clinic Health Examination Survey in Finland. The baseline examinations, including the collection of blood samples, were performed in 1968–1972. During a median followup of 10 years, 1, 096 new cancer cases were identified from the files of the Finish Cancer Registry. Selenium concentrations were measured from the stored serum samples collected from these cancer cases and from two controls per case, matched for sex, municipality, and age. The mean serum selenium level was 59.1 µg/L among all male cancer cases and 62.5 µg/L among controls. The difference was statistically significant (P<.001). Corresponding values among women were 63.6 and 63.9 µg/L, Respectively. Low serum selenium levels were associated with an increased risk of developing cancer at several sites, especially cancers of the stomach and lung among men. The relative risk of lung cancer between the highest and lowest decile of serum selenium was 0.11, and it differed significantly from unity (P<.001). These findings are in agreement with the hypothesis that low selsenium intake may increase the risk of some cancers among men. [J Natl Cancer Inst 82: 864–868, 1990]
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