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JNCI Journal of the National Cancer Institute 1989 81(24):1913-1917; doi:10.1093/jnci/81.24.1913
© 1989 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 81, No. 24, 1913-1917, December 20, 1989
© 1989 Oxford University Press

Detection of the Tumor-Associated Glycoprotein Antigen (TAG-72) in Premalignant Lesions of the Colon

Barbara C. Wolf*,, John C. D'Emilia, Ronald R. Salem, Deborah DeCoste, Henry F. Sears, Leonard S. Gottlieb, Glenn D. Steele, Jr.

1Department of Surgery, Laboratory of Cancer Biology, New England Deaconess Hospital and Harvard Medical School Boston, MA
2Mallory Institute of Pathology and Boston University School of Medicine Boston, MA

*Correspondence to: Dr. Barbara C. Wolf, Laboratory of Cancer Biology, New England Deaconess Hospital, 50 Binney St., Boston, MA 02115

We used monoclonal antibody B72.3 to study the expression of the colorectal carcinoma-associated antigen TAG-72 in premalignant colonic lesions with the immunoperoxidase technique. This antigen, which is rarely detectable in the normal colonic epithelium, was expressed in 13 of 19 adenomas with moderate to severe dysplasia and nine of nine cases of inflammatory bowel disease. The antibody reacted with the normal-appearing mucosa adjacent to a carcinoma in 10 of 12 cases, although only eight of the tumors expressed the antigen. The expression of the TAG-72 antigen in the colonic epithelium may be an early marker of malignant transformation. (J Natl Cancer Inst 81: 1913–1917, 1989).


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