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JNCI Journal of the National Cancer Institute 1989 81(23):1823-1828; doi:10.1093/jnci/81.23.1823
© 1989 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 81, No. 23, 1823-1828, December 6, 1989
© 1989 Oxford University Press

Induction of Antitumor Immunity in Mice by Allo-Major Histocompatibility Complex Class I Gene Transfectant With Strong Antigen Expression

Ken-ichi Isobe*, Yoshinori Hasegawa, Takashi Iwamoto, Tadao Hasegawa, Kohei Kawashima, Lin-na Ding, Izumi Nakashima

Department of Immunology Nagoya, Japan
First Department of Internal Medicine Nagoya, Japan
Clinical Laboratory, Nagoya University School of Medicine Nagoya, Japan

*Correspondence to: Ken-ichi Isobe, M.D., Department of Immunology, Nagoya University School of Medicine, Nagoya, Aichi 466, Japan.

An allo-major histocompatibility complex class I gene (H-2Kb) was transfected to murine mastocytoma P1.HTR (P815 subline) cells, after which several transfectant clones were obtained. Two clones, which expressed a low level of H-2Kb antigen, grew well and killed the syngeneic DBA/2 mice when they were inoculated ip. These mice lived longer than the mice given injections of the parental P1.HTR tumor. However, one clone, which expressed a high level of H-2Kb antigen, was rejected completely by the syngeneic DBA/2 mice and induced a generation of H-2Kb-specific cytotoxic T cells. Interestingly, the mice that had rejected the clone with high H-2Kb expression received strong antitumor immunity for rejection of the parental P1.HTR tumor challenged at the high dose. [J Natl Cancer Inst 81:1823–1828, 1989]


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