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JNCI Journal of the National Cancer Institute 1989 81(1):63-67; doi:10.1093/jnci/81.1.63
© 1989 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 81, No. 1, 63-67, January 1989
© 1989 Oxford University Press

Overexpression of N-ras Oncogene and Epidermal Growth Factor Receptor Gene in Human Glioblastomas

Massimo A. Gerosa, Daniela Talarico, Caterina Fognani, Elena Raimondi, Marco Colombatti, Giuseppe Tridente, Luigi De Carli, Giuliano Della valle

Departments of Neurosurgery, University of Verona Verona, Italy
Departments of Immunology, University of Verona Verona, Italy
Departments of Genetics and Microbiology "A. Buzzati-Traverso," University of Pavia Pavia, Italy
Department of Animal Biology, University of Catania Catania, Italy

Correspondence to: Dr. Massimo A. Gerosa, Dept. of Neurosurgery, Ospedale Geriatrico, Via Mameli, 37100 Verona, Italy.

Present address: D. Talarico, Department of Pathology, New York University Medical Center, New York, NY. G. Della Valle, Department of Animal Biology, University of Catania, Catania, Italy.

Five human glioblastoma cell lines were analyzed for oncogene activation with a panel of probes. Abnormal expression of the epidermal growth factor receptor (EGFr) gene was detected in four of five lines; N-ras oncogene overexpression was found in all five cell lines. These results were subsequently confirmed with fresh brain tumor and nonneoplastic brain tissue biopsy samples; increased expression of the N-ras proto-oncogene was observed in five of five glioblastomas, all of which also showed EGFr gene overex-pression, but not in well-differentiated gliomas or in nonneoplastic brain tis-sue specimens. No significant differ-ences in Ha-ras and Ki-ras expression were observed. Preliminary histochem-ical observations showed that intra-cellular levels of transforming growth factor {alpha}, a putative biochemical link between these two oncogenes, were significantly higher in glioblastoma cells than in controls. [J Natl Cancer Inst 1989;81:63–67]


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